ChemicalBook > CAS DataBase List > 5-CYANO-2-METHYLPYRIDINE
5-CYANO-2-METHYLPYRIDINE
- Product Name
- 5-CYANO-2-METHYLPYRIDINE
- CAS No.
- 3222-48-8
- Chemical Name
- 5-CYANO-2-METHYLPYRIDINE
- Synonyms
- 5-Cyan;5-CYANO-2-PICOLINE;6-Methylnicotinitrile;6-METHYLNICOTINONITRILE;5-CYANO-2-METHYLPYRIDINE;3-CYANO-6-METHYLPYRIDINE;2-Methyl-5-cyanopyridine;5-CYANO-2-METHYLPYRIDINE 99%;5-Cyano-2-methylpyridine >6-Methylpyridin-3-carbonitrile
- CBNumber
- CB0425476
- Molecular Formula
- C7H6N2
- Formula Weight
- 118.14
- MOL File
- 3222-48-8.mol
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5-CYANO-2-METHYLPYRIDINE Property
- Melting point:
- 83-85°C
- Boiling point:
- 216-217°C
- Density
- 1.08±0.1 g/cm3(Predicted)
- Flash point:
- 216-217°C
- storage temp.
- 2-8°C
- pka
- 2.51±0.10(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- BRN
- 111235
- InChIKey
- PBLOYQAQGYUPCM-UHFFFAOYSA-N
- CAS DataBase Reference
- 3222-48-8(CAS DataBase Reference)
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Safety
- Hazard Codes
- T+,T
- Risk Statements
- 22-41-25
- Safety Statements
- 26-36/37/39-45-39
- RIDADR
- 3439
- WGK Germany
- 1
- Hazard Note
- Harmful
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2933399990
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 735388
- Product name
- 6-Methylpyridine-3-carbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $39
- Updated
- 2023/06/20
TCI Chemical
- Product number
- C3050
- Product name
- 5-Cyano-2-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $46
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C3050
- Product name
- 5-Cyano-2-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $182
- Updated
- 2025/07/31
TRC
- Product number
- C981875
- Product name
- 5-Cyano-2-methylpyridine
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
TRC
- Product number
- C981875
- Product name
- 5-Cyano-2-methylpyridine
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
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5-CYANO-2-METHYLPYRIDINE Chemical Properties,Usage,Production
Uses
5-Cyano-2-methylpyridine is used to synthesize acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH). It is also used in the preparation of potent and selective nonpeptidic inhibitors of procollagen C-proteinase.This compound is suitable for pyruvate dehydrogenase (PDH) related research.
Synthesis
155265-57-9
3222-48-8
General procedure for the synthesis of 5-cyano-2-methylpyridine from 2-bromo-6-methylnicotinonitrile: a generalized method using Pd(OAc)2-PPh3, Pd2(dba)3-tbpf, Pd2(dba)3-DavePhos, Pd2(dba)3-P(t-Bu)3, Pd2(dba)3-XantPhos or Pd (OAc)2-XPhos as catalyst systems. First, anhydrous THF (13.2 mL) was degassed by bubbling argon for a few minutes, followed by the addition of Pd(OAc)2 (7.2 mg, 0.033 mmol, 5 mol%) and PPh3 (17.7 mg, 0.132 mmol, 20 mol%) and stirring of the resulting mixture for 30 minutes at room temperature. Next, halogenated heterocycles (0.66 mmol), TMEDA (0.130 g, 1.12 mmol, 1.7 eq.) and NaBH4 (42.4 mg, 1.12 mmol, 1.7 eq.) were added sequentially. The reaction mixture was stirred at room temperature or heated under argon protection at 65 °C for an appropriate time. After completion of the reaction, the residue was dissolved in brine and extracted with ethyl acetate. The organic phase was separated, dried and the solvent was evaporated, and finally the residue was purified by fast chromatography (using a mixture of petroleum ether and ethyl acetate) to give the pure hydrodehalogenated heterocyclic product.
References
[1] Tetrahedron Letters, 2010, vol. 51, # 12, p. 1562 - 1565
[2] Journal of Molecular Catalysis A: Chemical, 2014, vol. 393, p. 191 - 209
5-CYANO-2-METHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CYANO-2-METHYLPYRIDINE manufacturers
Dideu Industries Group Limited
- Product
- 5-CYANO-2-METHYLPYRIDINE 3222-48-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 5-CYANO-2-METHYLPYRIDINE 3222-48-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
Career Henan Chemical Co
- Product
- 5-CYANO-2-METHYLPYRIDINE 3222-48-8
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04
3222-48-8, 5-CYANO-2-METHYLPYRIDINERelated Search:
Ethyl 2-chloro-3-cyano-6-methylpyridine-4-,ETHYL 2-CHLORO-3-CYANO-6-METHYLPYRIDINE-4-CARBOXYLATE
3-CYANO-4,6-DIMETHYL-2-MERCAPTOPYRIDINE
Ethyl 3-cyano-2-mercapto-6-methylisonicotinate
5-CYANO-2-METHYLPYRIDINE
2-CHLORO-3-CYANO-6-METHYLPYRIDINE,2-CHLORO-3-CYANO-6-METHYLPYRIDINE 99%
2-Chloro-3-cyano-4,6-dimethylpyridine
3-Cyano-2,6-Dichloro-4-Methylpyridine 2,6-Dichloro-3-Cyano-4-Methylpyridine,2,6-DICHLORO-3-CYANO-4-METHYLPYRIDINE
Ethyl 2-chloro-5-cyano-6-Methylnicotinate
3-CYANO-5-METHYLPYRIDINE
3-Methylpicolinonitrile
6-Methylpyridine-2-carbonitrile
3-Cyano-2-methylpyridine
2-CYANO-5-METHYLPYRIDINE (2-CYANO-5-PICOLINE),2-CYANO-5-METHYLPYRIDINE
3-CYANO-4-METHYLPYRIDINE
4-CYANO-2-METHYLPYRIDINE
2-CYANO-4-METHYLPYRIDINE (2-CYANO-4-PICOLINE),2-Cyano-4-methylpyridine, 4-Methyl-2-cyanopyridine,2-Cyano-4-methylpyridine ,98%,2-CYANO-4-METHYLPYRIDINE
6-AMINO-3-CYANO-2-METHYLPYRIDINE,6-Amino-3-cyano-2-methylpyridine 97%
2,6-DIHYDROXY-3-CYANO-4-METHYLPYRIDINE