ChemicalBook > CAS DataBase List > 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

Product Name
1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
CAS No.
844891-04-9
Chemical Name
1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
Synonyms
1,3,5-Trimethylpyrazole-4-boronic Acid Pinacol Ester;1,3,5-TRIMETHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1,3,5-Trimethyl-1H-pyrazole-4-boronicacid,pinacolester97%;1,3,5-Trimethyl-1H-pyrazol-4-ylboronic acid pinacol ester;1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester 97%;1,3,5-triMethyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-py;1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester;1,3,5-triMethyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;2-(1,3,5-Trimethyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(1,3,5-Trimethylpyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CBNumber
CB0465973
Molecular Formula
C12H21BN2O2
Formula Weight
236.12
MOL File
844891-04-9.mol
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1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Property

Melting point:
91-93°C
Boiling point:
335.7±42.0 °C(Predicted)
Density 
1.04±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
3.13±0.10(Predicted)
color 
White to Almost white
InChIKey
IZNGYNMIIVJWSO-UHFFFAOYSA-N
CAS DataBase Reference
844891-04-9
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39-36-22
WGK Germany 
3
Hazard Note 
Harmful
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
654396
Product name
1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester
Purity
97%
Packaging
500mg
Price
$185
Updated
2023/06/20
Sigma-Aldrich
Product number
654396
Product name
1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester
Purity
97%
Packaging
1g
Price
$250
Updated
2023/06/20
TCI Chemical
Product number
T3409
Product name
1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
T3409
Product name
1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$117
Updated
2025/07/31
TRC
Product number
T798278
Product name
1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging
10mg
Price
$45
Updated
2021/12/16
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1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Chemical Properties,Usage,Production

Synthesis

857530-80-4

74-88-4

844891-04-9

General procedure for the synthesis of 1,3,5-trimethyl-1H-pyrazole-4-boronic acid pinacol ester from 3,5-dimethylpyrazole-4-boronic acid pinacol ester and iodomethane: 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (500 mg, 2.25 mmol) was suspended in acetone (5 mL) in acetone (5 mL), potassium carbonate (622 mg, 4.5 mmol) and iodomethane (0.21 mL, 3.37 mmol) were added. The reaction mixture was heated to 60 °C and kept for 4.5 hours. After completion of the reaction, it was cooled to room temperature, water was added, the aqueous phase was separated and extracted three times with ethyl acetate (EtOAc). The organic phases were combined, washed with water, dried over anhydrous magnesium sulfate (MgSO4), and concentrated in vacuo to afford 1,3,5-trimethyl-1H-pyrazole-4-boronic acid pinacol ester (403 mg, 76%) as a light yellow oil.LCMS (ES+) m/z 237 (M+H)+, retention time (RT) 3.35 min (Method 1).

References

[1] Patent: WO2009/71895, 2009, A1. Location in patent: Page/Page column 117
[2] Patent: US2016/176882, 2016, A1. Location in patent: Paragraph 0366; 0367
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00174
[4] Patent: WO2013/96153, 2013, A1. Location in patent: Page/Page column 173-174

1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE manufacturers

Career Henan Chemical Co
Product
1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 844891-04-9
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
1kg; 5kg
Release date
2020-02-03

844891-04-9, 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLERelated Search:

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Pinacol vinylboronate 1-ISOPROPYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER 2-Aminopyrimidine-5-boronic Acid Pinacol Ester Bis(pinacolato)diboron 1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester 1-Boc-pyrazole-4-boronic acid pinacol ester 4-Pyrazoleboronic acid pinacol ester 1H-PYRAZOLE-4-BORONIC ACID Pentaborane 1-TERT-BUTOXYCARBONYL-3,5-DIMETHYLPYRAZOLE-4-BORONIC ACID, PINACOL ESTER 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1-(2,2-DIMETHOXY-ETHYL)-3,5-DIMETHYL-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-PYRAZOLE

  • 1,3,5-TRIMETHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER
  • 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
  • 1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester 97%
  • 1,3,5-triMethyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
  • 1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
  • 2-(1,3,5-Trimethylpyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 1,3,5-Trimethyl-1H-pyrazole-4-boronicacid,pinacolester97%
  • 1,3,5-Trimethylpyrazole-4-boronic Acid Pinacol Ester
  • 1,3,5-triMethyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-py
  • 1H-Pyrazole, 1,3,5-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 2-(1,3,5-Trimethyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 1,3,5-Trimethyl-1<i>H</i>-pyrazole-4-boronic acid pinacol ester
  • 1,3,5-trimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [T25603]
  • 1,3,5-Trimethyl-1H-pyrazol-4-ylboronic acid pinacol ester
  • 844891-04-9
  • C12H21BN2O2