1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

Product Name: 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
CAS No.: 844891-04-9
Chemical Name: 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
Synonyms: 1,3,5-Trimethylpyrazole-4-boronic Acid Pinacol Ester;1,3,5-TRIMETHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1,3,5-Trimethyl-1H-pyrazole-4-boronicacid,pinacolester97%;1,3,5-Trimethyl-1H-pyrazol-4-ylboronic acid pinacol ester;1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester 97%;1,3,5-triMethyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-py;1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester;1,3,5-triMethyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;2-(1,3,5-Trimethyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(1,3,5-Trimethylpyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CBNumber: CB0465973
Molecular Formula: C12H21BN2O2
Formula Weight: 236.12
MOL File: 844891-04-9.mol

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1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Property

Melting point:: 91-93°C
Boiling point:: 335.7±42.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: soluble in Methanol
form: powder to crystal
pka: 3.13±0.10(Predicted)
color: White to Almost white
InChIKey: IZNGYNMIIVJWSO-UHFFFAOYSA-N
CAS DataBase Reference: 844891-04-9

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39-36-22
WGK Germany: 3
Hazard Note: Harmful
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 654396
Product name: 1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 500mg
Price: $185
Updated: 2023/06/20

Sigma-Aldrich

Product number: 654396
Product name: 1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $250
Updated: 2023/06/20

TCI Chemical

Product number: T3409
Product name: 1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: T3409
Product name: 1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $117
Updated: 2025/07/31

Usbiological

Product number: 291008
Product name: 1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester
Packaging: 1g
Price: $523
Updated: 2021/12/16

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1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Chemical Properties,Usage,Production

Synthesis

857530-80-4

74-88-4

844891-04-9

General procedure for the synthesis of 1,3,5-trimethyl-1H-pyrazole-4-boronic acid pinacol ester from 3,5-dimethylpyrazole-4-boronic acid pinacol ester and iodomethane: 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (500 mg, 2.25 mmol) was suspended in acetone (5 mL) in acetone (5 mL), potassium carbonate (622 mg, 4.5 mmol) and iodomethane (0.21 mL, 3.37 mmol) were added. The reaction mixture was heated to 60 °C and kept for 4.5 hours. After completion of the reaction, it was cooled to room temperature, water was added, the aqueous phase was separated and extracted three times with ethyl acetate (EtOAc). The organic phases were combined, washed with water, dried over anhydrous magnesium sulfate (MgSO4), and concentrated in vacuo to afford 1,3,5-trimethyl-1H-pyrazole-4-boronic acid pinacol ester (403 mg, 76%) as a light yellow oil.LCMS (ES+) m/z 237 (M+H)+, retention time (RT) 3.35 min (Method 1).

References

[1] Patent: WO2009/71895, 2009, A1. Location in patent: Page/Page column 117
[2] Patent: US2016/176882, 2016, A1. Location in patent: Paragraph 0366; 0367
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00174
[4] Patent: WO2013/96153, 2013, A1. Location in patent: Page/Page column 173-174

1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE Suppliers

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View Lastest Price from 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE manufacturers

Career Henan Chemical Co

Product: 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 844891-04-9
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 1kg; 5kg
Release date: 2020-02-03

844891-04-9, 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLERelated Search:

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester Pinacol vinylboronate 1-ISOPROPYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER 2-Aminopyrimidine-5-boronic Acid Pinacol Ester Bis(pinacolato)diboron 1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester 1-Boc-pyrazole-4-boronic acid pinacol ester 4-Pyrazoleboronic acid pinacol ester 1H-PYRAZOLE-4-BORONIC ACID Pentaborane 1-TERT-BUTOXYCARBONYL-3,5-DIMETHYLPYRAZOLE-4-BORONIC ACID, PINACOL ESTER 1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1-(2,2-DIMETHOXY-ETHYL)-3,5-DIMETHYL-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1,3,5-TRIMETHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER

1,3,5-TRIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1,3,5-Trimethyl-1H-pyrazole-4-boronic acid pinacol ester 97%

1,3,5-triMethyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

2-(1,3,5-Trimethylpyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1,3,5-Trimethyl-1H-pyrazole-4-boronicacid,pinacolester97%

1,3,5-Trimethylpyrazole-4-boronic Acid Pinacol Ester

1,3,5-triMethyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-py

1H-Pyrazole, 1,3,5-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-(1,3,5-Trimethyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1,3,5-Trimethyl-1<i>H</i>-pyrazole-4-boronic acid pinacol ester

1,3,5-trimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [T25603]

1,3,5-Trimethyl-1H-pyrazol-4-ylboronic acid pinacol ester

844891-04-9

C12H21BN2O2