VU0661013

Product Name: VU0661013
CAS No.: 2131184-57-9
Chemical Name: VU0661013
Synonyms: VU661013;VU0661013;1H-Indole-5-carboxylic acid, 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-
CBNumber: CB04845069
Molecular Formula: C39H39Cl2N5O4
Formula Weight: 712.66
MOL File: 2131184-57-9.mol

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VU0661013 Property

Boiling point:: 906.4±65.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥125mg/mL in DMSO;insoluble in H2O
pka: 4.44±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A8783
Product name: VU661013
Packaging: 5mg
Price: $866
Updated: 2021/12/16

ApexBio Technology

Product number: A8783
Product name: VU661013
Packaging: 10mg
Price: $1339
Updated: 2021/12/16

ApexBio Technology

Product number: A8783
Product name: VU661013
Packaging: 25mg
Price: $2756
Updated: 2021/12/16

ApexBio Technology

Product number: A8783
Product name: VU661013
Packaging: 50mg
Price: $4331
Updated: 2021/12/16

DC Chemicals

Product number: DC12064
Product name: VU0661013
Purity: >98%
Packaging: 1g
Price: $3600
Updated: 2021/12/16

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VU0661013 Chemical Properties,Usage,Production

Biological Activity

vu661013 is a novel, potent, selective mcl-1 inhibitor (ki of 97 ± 30 pm).[1]mcl-1, an anti-apoptotic bcl-2 family member, is commonly upregulated in acute myeloblastic leukemia (aml) cells. targeting anti-apoptotic proteins in aml is a key therapeutic strategy, and mcl-1 is a critical anti-apoptotic oncoprotein. [1]vu661013 reduced expansion of multiple aml cell lines in vitro. venetoclax (a bcl-2 inhibitor) and vu661013 exhibited favorable synergy in several of aml cells lines, venetoclax-resistant aml cells were sensitive to vu661013. [1]vu661013 decreased tumor growth in an in vivo murine model. vu661013 (25mg/kg) and venetoclax (15mg/kg) can be synergistic in patient-derived xenograft transplantation models. [1][1]a novel mcl-1 inhibitor combined with venetoclax rescues venetoclax resistant acute myelogenous leukemia. cancer discov. 2018 sep 5. pmid: 30185627. doi: 10.1158/2159-8290.cd-18-0140

VU0661013 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU0661013 Suppliers

China 19 United States 3 Global 22

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2131184-57-9, VU0661013Related Search:

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU0134992(hydrochloride) VU6005649 VU 591 hydrochloride VU0810464 VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 6008667 (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121 VU 0360223 VU 0364439 VU0650786

VU0661013

VU661013

1H-Indole-5-carboxylic acid, 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-

2131184-57-9

C39H39Cl2N5O4