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ACA

Product Name
ACA
CAS No.
110683-10-8
Chemical Name
ACA
Synonyms
ACA;4-amylcinnamoylanthranilicacid;N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID;N-(p-Amylcinnamoyl) anthranilic Acid (ACA);2-(3-(4-Pentylphenyl)acrylamido)benzoic acid;2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID;Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-;N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor
CBNumber
CB0489432
Molecular Formula
C21H23NO3
Formula Weight
337.41
MOL File
110683-10-8.mol
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ACA Property

Melting point:
172-174℃
Boiling point:
563.1±50.0 °C(Predicted)
Density 
1.178±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
pka
3.49±0.36(Predicted)
form 
White solid.
color 
White to Off-White
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Safety

HazardClass 
9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J67339
Product name
N-(4-n-Pentylcinnamoyl)anthranilic acid
Packaging
50mg
Price
$151
Updated
2023/06/20
Cayman Chemical
Product number
14531
Product name
N-(p-amylcinnamoyl) Anthranilic Acid
Purity
≥95%
Packaging
25mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
14531
Product name
N-(p-amylcinnamoyl) Anthranilic Acid
Purity
≥95%
Packaging
50mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
14531
Product name
N-(p-amylcinnamoyl) Anthranilic Acid
Purity
≥95%
Packaging
100mg
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
14531
Product name
N-(p-amylcinnamoyl) Anthranilic Acid
Purity
≥95%
Packaging
250mg
Price
$330
Updated
2024/03/01
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ACA Chemical Properties,Usage,Production

Uses

N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.

Definition

ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide.

References

harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6.

ACA Preparation Products And Raw materials

Raw materials

Preparation Products

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ACA Suppliers

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110683-10-8, ACARelated Search:

Inositol alpha-Amylcinnamaldehyde H-6-Aca-OH~epsilon-Aminocaproic acid~6-Aminohexanoic acid~EACA,h-6-aca-oh Boc-6-AMinocaproic acid 7-TMCA Hydroxymethyl-7-ACA N-Benzyloxycarbonyl-6-aminohexanoic acid 7-ACA-3-MTT-7-MO,7-ACA-3-MTT-7-MO / 7-MAC ACA 7-ACA 7-Aca-3-SmtC10H12N6O6S3,7-aca-3-smt FMOC-6-ACA-OH ECPP-ACA Glutaryl-7-ACA acylase ACA 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID ACA AKOS BBS-00007306

  • 2-(3-(4-Pentylphenyl)acrylamido)benzoic acid
  • N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID
  • 4-amylcinnamoylanthranilicacid
  • 2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID
  • N-(p-Amylcinnamoyl) anthranilic Acid (ACA)
  • ACA
  • Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-
  • N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor
  • 110683-10-8