ChemicalBook > CAS DataBase List > ACA

ACA

Product Name: ACA
CAS No.: 110683-10-8
Chemical Name: ACA
Synonyms: ACA;4-amylcinnamoylanthranilicacid;N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID;N-(p-Amylcinnamoyl) anthranilic Acid (ACA);2-(3-(4-Pentylphenyl)acrylamido)benzoic acid;2-[3-(4-pentylphenyl)prop-2-enamido]benzoic acid;N-(p-amylcinnamoyl) Anthranilic Acid, 10 mM in DMSO;2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID;Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-;N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor
CBNumber: CB0489432
Molecular Formula: C21H23NO3
Formula Weight: 337.41
MOL File: 110683-10-8.mol

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ACA Property

Melting point:: 172-174℃
Boiling point:: 563.1±50.0 °C(Predicted)
Density: 1.178±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
pka: 3.49±0.36(Predicted)
form: White solid.
color: White to Off-White

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Safety

HazardClass: 9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H410Very toxic to aquatic life with long lasting effects
Precautionary statements: P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14531
Product name: N-(p-amylcinnamoyl) Anthranilic Acid
Purity: ≥95%
Packaging: 25mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14531
Product name: N-(p-amylcinnamoyl) Anthranilic Acid
Purity: ≥95%
Packaging: 50mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 14531
Product name: N-(p-amylcinnamoyl) Anthranilic Acid
Purity: ≥95%
Packaging: 100mg
Price: $168
Updated: 2024/03/01

Cayman Chemical

Product number: 14531
Product name: N-(p-amylcinnamoyl) Anthranilic Acid
Purity: ≥95%
Packaging: 250mg
Price: $330
Updated: 2024/03/01

TRC

Product number: A636525
Product name: N-(p-Amylcinnamoyl)anthranilic acid
Packaging: 50mg
Price: $85
Updated: 2021/12/16

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ACA Chemical Properties,Usage,Production

Uses

N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.

Definition

ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide.

Biological Activity

Cell permeable: yes', 'Primary Target
A2PLA2', 'Product does not compete with ATP.', 'Reversible: no

References

harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6.

ACA Preparation Products And Raw materials

Raw materials

Preparation Products

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110683-10-8, ACARelated Search:

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2-(3-(4-Pentylphenyl)acrylamido)benzoic acid

N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID

4-amylcinnamoylanthranilicacid

2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID

N-(p-Amylcinnamoyl) anthranilic Acid (ACA)

ACA

Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-

N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor

2-[3-(4-pentylphenyl)prop-2-enamido]benzoic acid

N-(p-amylcinnamoyl) Anthranilic Acid, 10 mM in DMSO

110683-10-8