ACA
- Product Name
- ACA
- CAS No.
- 110683-10-8
- Chemical Name
- ACA
- Synonyms
- ACA;4-amylcinnamoylanthranilicacid;N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID;N-(p-Amylcinnamoyl) anthranilic Acid (ACA);2-(3-(4-Pentylphenyl)acrylamido)benzoic acid;2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID;Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-;N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor
- CBNumber
- CB0489432
- Molecular Formula
- C21H23NO3
- Formula Weight
- 337.41
- MOL File
- 110683-10-8.mol
ACA Property
- Melting point:
- 172-174℃
- Boiling point:
- 563.1±50.0 °C(Predicted)
- Density
- 1.178±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- pka
- 3.49±0.36(Predicted)
- form
- White solid.
- color
- White to Off-White
Safety
- HazardClass
- 9
N-Bromosuccinimide Price
- Product number
- J67339
- Product name
- N-(4-n-Pentylcinnamoyl)anthranilic acid
- Packaging
- 50mg
- Price
- $151
- Updated
- 2023/06/20
- Product number
- 14531
- Product name
- N-(p-amylcinnamoyl) Anthranilic Acid
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 14531
- Product name
- N-(p-amylcinnamoyl) Anthranilic Acid
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 14531
- Product name
- N-(p-amylcinnamoyl) Anthranilic Acid
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 14531
- Product name
- N-(p-amylcinnamoyl) Anthranilic Acid
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $330
- Updated
- 2024/03/01
ACA Chemical Properties,Usage,Production
Uses
N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.
Definition
ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide.
References
harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6.