5-Bromo-2-chloronicotinic acid

Product Name: 5-Bromo-2-chloronicotinic acid
CAS No.: 29241-65-4
Chemical Name: 5-Bromo-2-chloronicotinic acid
Synonyms: 5-Bromo-2-Chloronicotinic;5-BROMO-2-CHLORONICOTINIC ACID;5-Bromo-2-chloronicotinic acid 97%;5-Bromo-2-chloronicotinic Acid >5-Bromo-2-chloronicotinic acid ,97%;5-bromo-2-chloropyridine-3-carboxylicaci;5-Bromo-2-chlorpyridine-3-carboxylic acid;5 - broMine - 2 - nicotinic acid chloride;5-Bromo-2-chloropyridin-3-carboxylic acid;5-BROMO-2-CHLORO-3-PYRIDINECARBOXYLIC ACID
CBNumber: CB0492683
Molecular Formula: C6H3BrClNO2
Formula Weight: 236.45
MOL File: 29241-65-4.mol

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5-Bromo-2-chloronicotinic acid Property

Melting point:: 173-176°C
Boiling point:: 345.1±42.0 °C(Predicted)
Density: 1.917±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: soluble in Methanol
form: Solid
pka: 1.61±0.25(Predicted)
color: White to Almost white
InChI: InChI=1S/C6H3BrClNO2/c7-3-1-4(6(10)11)5(8)9-2-3/h1-2H,(H,10,11)
InChIKey: UKNYSJCAGUXDOQ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Br)C=C1C(O)=O
CAS DataBase Reference: 29241-65-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, KEEP COLD
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3883
Product name: 5-Bromo-2-chloronicotinic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $86
Updated: 2025/07/31

TRC

Product number: B684108
Product name: 5-Bromo-2-chloronicotinic Acid
Packaging: 500mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B684108
Product name: 5-Bromo-2-chloronicotinic Acid
Packaging: 5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J93149
Product name: 5-Bromo-2-chloronicotinic Acid
Packaging: 25g
Price: $30
Updated: 2021/12/16

Apolloscientific

Product number: OR6261
Product name: 5-Bromo-2-chloronicotinic Acid
Purity: 97%
Packaging: 25g
Price: $34
Updated: 2021/12/16

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5-Bromo-2-chloronicotinic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Synthesis

104612-36-4

29241-65-4

Step B. Synthesis of 5-bromo-2-chloronicotinic acid. A mixture of 5-bromo-2-hydroxynicotinic acid (32.9 g, 0.151 mol), dichlorosulfoxide (167 mL), and N,N-dimethylformamide (10.5 mL) was heated to reflux for 4 hours at 70°C. The reaction was carried out with the addition of water. Upon completion of the reaction, the mixture was concentrated, cooled to 0°C, and the reaction was quenched by the slow addition of water to give an off-white precipitate. The precipitate was stirred in water for 1 h and subsequently collected by filtration and dried under vacuum to give 5-bromo-2-chloronicotinic acid (35.5 g, 99% yield). The product can be used directly in the subsequent reaction without further purification or can be purified by recrystallization in hot water. Mass spectrum (electrospray ionization): calculated value C6H3BrClNO2, 234.90; measured value m/z, 236.2 [M + H]+. 1H NMR (acetone-d6): δ 8.66 (d, J = 2.5 Hz, 1H), 8.43 (d, J = 2.5 Hz, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2566 - 2569
[2] Patent: US2006/287292, 2006, A1. Location in patent: Page/Page column 26
[3] European Journal of Organic Chemistry, 2010, # 28, p. 5397 - 5401
[4] Synthetic Communications, 1989, vol. 19, # 3and4, p. 553 - 560
[5] Patent: WO2010/136817, 2010, A1. Location in patent: Page/Page column 113

5-Bromo-2-chloronicotinic acid Preparation Products And Raw materials

Raw materials

2-Hydroxynicotinic acid N,N-Dimethylformamide Hydrochloric acid Bromine Sodium hydroxide Thionyl chloride

Preparation Products

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View Lastest Price from 5-Bromo-2-chloronicotinic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Bromo-2-chloronicotinic acid 29241-65-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Dideu Industries Group Limited

Product: 5-Bromo-2-chloronicotinic acid 29241-65-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Bromo-2-chloronicotinic acid 29241-65-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

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5-Bromo-2-chloronicotinic acid CAS NO.29241-65-4

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29241-65-4

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