Thiophene-3-ethanol

Product Name: Thiophene-3-ethanol
CAS No.: 13781-67-4
Chemical Name: Thiophene-3-ethanol
Synonyms: 2-(thiophen-3-yl)ethan-1-ol;3-THIOPHENEETHANOL;2-(thiophen-3-yl)ethanol;2-(3-ThienyL;THIOPHENE-3-ETHANOL;Thiophen-3-ylethanol;2-(3-THIENYL)ETHANOL;3-Thiopheneethanol 99%;Clopidogrel Impurity 51;3-THIOPHENEETHANOL 98+%
CBNumber: CB0492744
Molecular Formula: C6H8OS
Formula Weight: 128.19
MOL File: 13781-67-4.mol

More

Less

Thiophene-3-ethanol Property

Boiling point:: 110-111 °C14 mm Hg(lit.)
Density: 1.144 g/mL at 25 °C(lit.)
refractive index: n20/D 1.552(lit.)
Flash point:: 199 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 14.92±0.10(Predicted)
form: Liquid
color: Clear colorless to yellow-brown
Specific Gravity: 1.144
Water Solubility: Sparingly soluble in water(0.059 g/L at 25°C).
BRN: 107080
InChIKey: YYPNNBPPDFTQFX-UHFFFAOYSA-N
LogP: 1.07
CAS DataBase Reference: 13781-67-4(CAS DataBase Reference)
NIST Chemistry Reference: 3-Thiopheneethanol(13781-67-4)

More

Less

Safety

Safety Statements: 23-24/25
WGK Germany: 3
F: 10
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H227Combustible liquid
Precautionary statements: P403+P235Store in a well-ventilated place. Keep cool.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 228796
Product name: 3-Thiopheneethanol
Purity: 99%
Packaging: 5g
Price: $83.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 228796
Product name: 3-Thiopheneethanol
Purity: 99%
Packaging: 25g
Price: $379.35
Updated: 2025/07/31

TCI Chemical

Product number: T1475
Product name: 3-Thiopheneethanol
Purity: >97.0%(GC)
Packaging: 5g
Price: $83
Updated: 2025/07/31

TCI Chemical

Product number: T1475
Product name: 3-Thiopheneethanol
Purity: >97.0%(GC)
Packaging: 25g
Price: $332
Updated: 2025/07/31

TRC

Product number: T344865
Product name: 3-Thiopheneethanol
Packaging: 1g
Price: $55
Updated: 2021/12/16

More

Less

Thiophene-3-ethanol Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellowish-brown liquid

Uses

3-Thiopheneethanol is used as a reagent in the synthesis of pH-responsive near-IR emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug delivery. 3-Thiopheneethanol is also used as a reagent in the preparation of potent respiratory syncytial virus RNA polymerase inhibitors.

Uses

3-Thiopheneethanol [3-(2-hydroxyethyl)thiophene] was used in the synthesis of various ether and ester derivatives such as 3-(2-(benzyloxy)ethyl)thiophene, 3-[2-((triphenylmethyl)oxy)ethyl]thiophene, 3-[2-((trimethylsilyl)oxy)ethyl]thiophene, 3-[2-((dimethyl-tert-butylsilyl)oxy)ethyl]thiophene, 3-(2-acetoxyethyl)thiophene and 3-(2-(benzoyloxy)ethyl)thiophene.

Synthesis

6964-21-2

13781-67-4

Step 2: Synthesis of 2-(thiophen-3-yl)ethanol 1. to LiAlH4 (4.56 g, 0.12 mol) was added tetrahydrofuran (200 mL) at 0 °C and the mixture was stirred. 2. Slowly add THF solution of 2-(thiophen-3-yl)acetic acid (14.2 g, 0.1 mol dissolved in 100 mL of THF) dropwise to the above mixture, keeping the temperature at 0 °C. 3. after the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 2 hours. 4. EtOAc (200 mL) was slowly added to the reaction mixture followed by water (5 mL) to quench the reaction. 5. The resulting suspension was filtered through diatomaceous earth and the filtrate was dried with anhydrous sodium sulfate. 6. The dried filtrate was concentrated to dryness to give 2-(thiophen-3-yl)ethanol (12.44 g, yield: 99%). 7. The product was characterized by 1H NMR (MeOD, 400 MHz): δ 5.92-5.87 (m, 1H), 5.69-5.66 (m, 1H), 5.57 (s, 1H), 2.90 (d, J=14.0 Hz, 1H), 2.38 (d, J=14 Hz, 1H), 1.55-1.42 (m, 2H).

References

[1] Patent: US2011/76291, 2011, A1. Location in patent: Page/Page column 148
[2] Synthesis, 2005, # 2, p. 267 - 271
[3] Synthesis (Germany), 2015, vol. 47, # 24, p. 3972 - 3982
[4] Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1994, vol. 256, p. 439 - 448
[5] Organic Process Research and Development, 2015, vol. 19, # 11, p. 1568 - 1575

Thiophene-3-ethanol Preparation Products And Raw materials

Raw materials

Nitrogen Tetrahydrofuran 3-Bromothiophene Lithium Aluminum Hydride n-Butyllithium Methyl chloroacetate

Preparation Products

More

Less

Thiophene-3-ethanol Suppliers

Belgium 2 Canada 1 China 208 France 1 Germany 4 India 7 Japan 3 Poland 2 Switzerland 3 The Netherlands 1 United Kingdom 11 United States 26 Global 269

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3982
Advantage: 60

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14332
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Alichem Inc.

Tel: --
Fax: --
Email: sales@alichem.com
Country: United States
ProdList: 6167
Advantage: 58

MilliporeSigma (Sigma-Aldrich Corp.)

Tel: --
Fax: --
Email: @sial.com
Country: United States
ProdList: 5414
Advantage: 58

VWR International, LLC.

Tel: --
Fax: --
Email: @sargentwelch.com
Country: United States
ProdList: 6262
Advantage: 58

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

TCI America, Inc. (part of Tokyo Chemical Industry)

Tel: --
Fax: --
Email: Angelina.Crew@tcichemicals.com
Country: United States
ProdList: 2053
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Anvia Chemicals, LLC

Tel: --
Fax: --
Email: sales@anviachem.com
Country: United States
ProdList: 3933
Advantage: 0

Wilshire Chemical Company Inc.

Tel: --
Fax: --
Email: WilshrChem@AOL.COM
Country: United States
ProdList: 3498
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Advanced Synthesis Technologies

Tel: --
Fax: --
Email: sales@advancedsynthesis.com
Country: United States
ProdList: 4775
Advantage: 61

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

More

Less

View Lastest Price from Thiophene-3-ethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Thiophene-3-ethanol 13781-67-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-20

Henan Aochuang Chemical Co.,Ltd.

Product: Thiophene-3-ethanol 13781-67-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

R&D Scientific Inc.

Product: 2-(Thiophen-3-yl)ethanol 13781-67-4
Price: US $320.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-02-19

13781-67-4, Thiophene-3-ethanolRelated Search:

Thiophene Ethyl acetate Thianaphthene 2-(METHYLSULFONYL)ETHANOL Ethanol Cephalothin sodium Thifensulfuron methyl 2-Thiophenecarboxaldehyde Tetrahydrothiophene 2-Thiazolecarboximidamide 2-Thiophenecarboxylic acid 2,5-Thiophenedicarboxylic acid Tioxolone 2,3-THIOPHENEDICARBOXALDEHYDE THIOPHENE-2-CARBOXALDOXIME 4-(2-THIAZOLYLAZO)RESORCINOL THIOPHENE-2-THIOCARBOXAMIDE N'-HYDROXY-2-THIOPHENECARBOXIMIDAMIDE

2-(3-Thienyl)ethanol, 3-(2-Hydroxyethy

3-(2-Hydroxyethyl)thiophene 98%

2-(thiophen-3-yl)ethanol

2-(3-Thienyl)ethanol, 3-(2-Hydroxyethyl)thiophene

2-(Thiophene-3-yl)ethanol

2-(3-Thienyl)ethanol,99%

2-(3-Thienyl)ethanol ,98%

2-(Thien-3-yl)ethan-1-ol

2-(3-Thienyl)ethanol, 99% 25GR

2-(3-Thienyl)ethanol, 99% 5GR

3-(2-Hydroxyethyl)thiophene 2-(3-Thienyl)ethanol

Thiophen-3-ylethanol

3-Thiopheneethanol 99%

2-(thiophen-3-yl)ethan-1-ol

Clopidogrel Impurity 51

2-(3-ThienyL

THIOPHENE-3-ETHANOL

2-(3-THIENYL)ETHANOL

3-(2-HYDROXYETHYL)THIOPHENE

3-THIOPHENEETHANOL

3-THIOPHENEETHANOL 98+%

2-(3-Thienyl)ethanol, 98%, for synthesis

Thiophene-3-ethanol ISO 9001：2015 REACH

3-Thiopheneethanol (6CI, 7CI, 8CI, 9CI, ACI)

13781-67-4

Building Blocks

Heterocyclic Building Blocks

Thiophenes

Reagents for Conducting Polymer Research

Thiophene Derivatives (for Conduting Polymer Research)

Thiophen

Functional Materials

Reagents for Conducting Polymer Research

Thiophene Derivatives (for Conduting Polymer Research)

Heterocycles

Thiophens

1