3-Amino-4-chlorophenol

Product Name: 3-Amino-4-chlorophenol
CAS No.: 16026-77-0
Chemical Name: 3-Amino-4-chlorophenol
Synonyms: 3-Amino-4-chlorophenol;4-chloro-3-amino phenol;Phenol, 3-amino-4-chloro-;3-AMINO-4-CHLOROPHENOL 97;3-Amino-4-chlorophenol 97%;3-AMino-4-chlorophenol
CBNumber: CB0499798
Molecular Formula: C6H6ClNO
Formula Weight: 143.57
MOL File: 16026-77-0.mol

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3-Amino-4-chlorophenol Property

Melting point:: 151-154 °C (lit.)
Boiling point:: 282.8±20.0 °C(Predicted)
Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Powder
pka: 9.57±0.18(Predicted)
color: Pale orange to brown
Water Solubility: Slightly soluble in water.
CAS DataBase Reference: 16026-77-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 552488
Product name: 3-Amino-4-chlorophenol
Purity: 97%
Packaging: 1g
Price: $73.3
Updated: 2023/06/20

Sigma-Aldrich

Product number: 552488
Product name: 3-Amino-4-chlorophenol
Purity: 97%
Packaging: 5g
Price: $184
Updated: 2023/06/20

TRC

Product number: A617735
Product name: 3-Amino-4-chlorophenol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J98867
Product name: 3-Amino-4-chlorophenol
Packaging: 5g
Price: $130
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021112
Product name: 3-AMINO-4-CHLOROPHENOL
Purity: 95.00%
Packaging: 1G
Price: $349.65
Updated: 2021/12/16

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3-Amino-4-chlorophenol Chemical Properties,Usage,Production

Uses

3-Amino-4-chlorophenol may be used in the synthesis of hydroxymethyl rhodamines (HMRs).

General Description

3-Amino-4-chlorophenol is formed as a product from the photochemical decomposition of 2,5-dichloroaniline.

Synthesis

610-78-6

16026-77-0

Step 1. Reduction reaction: 4-chloro-3-nitrophenol (6.0 g, 34.6 mmol) and acetic acid (60 mL) were added to a 100-mL round-bottom flask equipped with a magnetic stir bar. Iron powder (325 mesh, 19.31 g, 346 mmol) was then added and the reaction mixture was heated with stirring at 100 °C for 30 min. After completion of the reaction, the mixture was cooled to room temperature and diluted with deionized water (40 mL). Step 2. Post-treatment: The diluted mixture was filtered through a diatomaceous earth pad and washed thoroughly with deionized water. The filtrate was extracted with ethyl acetate and the organic phases were combined and concentrated under reduced pressure. Step 3. Purification: Heptane (~100 mL) was added to the concentrated residue, followed by evaporation under reduced pressure to remove residual acetic acid and water, and the process was repeated. The final residue was dissolved in acetonitrile and concentrated again under reduced pressure. The resulting solid was suspended in heptane and concentrated under reduced pressure to afford 3-amino-4-chlorophenol (4.38 g, 88% yield) as a lavender to amber solid. The mass spectrum (ESI, cation mode) showed m/z 144 [M + 1].

References

[1] Journal of Organic Chemistry, 2013, vol. 78, # 9, p. 4530 - 4542
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 21, p. 3454 - 3457
[3] Patent: WO2015/74064, 2015, A2. Location in patent: Paragraph 0227
[4] Journal of the Brazilian Chemical Society, 2016, vol. 27, # 2, p. 372 - 381

3-Amino-4-chlorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-4-chlorophenol Suppliers

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View Lastest Price from 3-Amino-4-chlorophenol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Amino-4-chlorophenol 16026-77-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 3-Amino-4-chlorophenol 16026-77-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-02

16026-77-0, 3-Amino-4-chlorophenolRelated Search:

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3-AMINO-4-CHLOROPHENOL 97

3-Amino-4-chlorophenol

3-<WBR>AMino-<WBR>4-<WBR>chlorophenol

3-Amino-4-chlorophenol 97%

Phenol, 3-amino-4-chloro-

4-chloro-3-amino phenol

16026-77-0

C6ClH6NO

Organic Building Blocks

Oxygen Compounds

Phenols