2-Chloro-1,3,2-dioxaphospholane-2-oxide

Product Name: 2-Chloro-1,3,2-dioxaphospholane-2-oxide
CAS No.: 6609-64-9
Chemical Name: 2-Chloro-1,3,2-dioxaphospholane-2-oxide
Synonyms: 2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE;ETHYLENE CHLOROPHOSPHATE;ETHYLENE CYCL-CHLOROPHOSPHATE;Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane);Ethylene chl;2-chloro-1,3,2;CYCLIC CHLOROPHOSPHATE;Ethylene chlorophosphate, tech. 90%;Ethylene glycol chlorophosphate, 95%;2-chloro-1,3,2λ?-dioxaphospholan-2-one
CBNumber: CB0664909
Molecular Formula: C2H4ClO3P
Formula Weight: 142.48
MOL File: 6609-64-9.mol

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2-Chloro-1,3,2-dioxaphospholane-2-oxide Property

Melting point:: 12-14 °C
Boiling point:: 89-91 °C0.8 mm Hg(lit.)
Density: 1.55 g/mL at 25 °C(lit.)
vapor pressure: 1.06hPa at 25℃
refractive index: n20/D 1.45(lit.)
Flash point:: >230 °F
storage temp.: -20°C
solubility: Chloroform (Soluble), Ethyl Acetate (Slightly)
form: Solid or Film
color: White to off-white
Water Solubility: Miscible with water and chloroform.
Sensitive: Moisture Sensitive
BRN: 606582
Stability:: Extremely moisture sensitive
InChIKey: SBMUNILHNJLMBF-UHFFFAOYSA-N
LogP: -0.485 at 25℃ and pH7
CAS DataBase Reference: 6609-64-9(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 14-34
Safety Statements: 26-36/37/39-45-8-25-27
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
F: 10
HazardClass: 8
PackingGroup: II
HS Code: 29209090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 377953
Product name: 2-Chloro-1,3,2-dioxaphospholane 2-oxide
Packaging: 5g
Price: $154
Updated: 2024/03/01

TCI Chemical

Product number: C1250
Product name: 2-Chloro-2-oxo-1,3,2-dioxaphospholane
Purity: >95.0%(GC)(T)
Packaging: 5g
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: C1250
Product name: 2-Chloro-2-oxo-1,3,2-dioxaphospholane
Purity: >95.0%(GC)(T)
Packaging: 25g
Price: $261
Updated: 2024/03/01

Alfa Aesar

Product number: A18320
Product name: Ethylene chlorophosphate
Purity: 95%
Packaging: 5g
Price: $77.7
Updated: 2023/06/20

Alfa Aesar

Product number: A18320
Product name: Ethylene chlorophosphate
Purity: 95%
Packaging: 25g
Price: $290
Updated: 2023/06/20

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2-Chloro-1,3,2-dioxaphospholane-2-oxide Chemical Properties,Usage,Production

Chemical Properties

clear colourless liquid

Uses

Ethylene chlorophosphate is used in the syntheses of 2-methacryloyoxyethylphophocholine, phosphatidylcholines, 2',3'-O-16-hentriacontanyliden-adenosine-5'-phosphocholine and hexadecylphosphocholine. It is also involved the synthesis of alpha-naphthylphosphorylcholine, which is used to detect phospholipase C activity. It is an important reactant for the synthesis of a zwitterionic silane, UV-polymerizable lipids utilizing Chabrier reaction and block copolymers of poly(aliphatic ester) clickable polyphosphoester.

Uses

2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:

2-methacryloyloxyethylphosphorylcholine
miltefosine (hexadecylphosphocholine, MT) analogs
phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester
uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)
adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)
structurally related phospholipids which are either conformationally restricted or flexible
phosphatidylcholines

Uses

2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.

General Description

2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen.

Purification Methods

It should be distilled under high vacuum as some polymerisation occurs at -1atmospheric pressure. It has IR bands at 3012, 2933, 1477, 1366, 1325, 1040, 924 and 858 cm . It is hydrolysed to HOCH2CH2OPO3H2 in 30minutes in H2O at 100o [IR: Cox & Westheimer J Am Chem Soc 80 5441 1958]. [Beilstein 1 IV 2419.]

2-Chloro-1,3,2-dioxaphospholane-2-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-1,3,2-dioxaphospholane-2-oxide Suppliers

Americas 1 Belgium 2 Canada 4 China 132 Europe 1 France 1 Germany 5 India 14 Japan 4 Poland 2 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 13 United States 28 Global 211

Yangzhou modier Electronic Materials Co., Ltd

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View Lastest Price from 2-Chloro-1,3,2-dioxaphospholane-2-oxide manufacturers

Hubei Langyou International Trading Co., Ltd

Product: 2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
Price: US $1000.00/KG
Min. Order: 10g
Purity: 99%
Supply Ability: 20tons
Release date: 2021-09-01

Hebei Mojin Biotechnology Co., Ltd

Product: 2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-07

Hebei Guanlang Biotechnology Co., Ltd.

Product: 2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
Price: US $19.90/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-04-23

6609-64-9, 2-Chloro-1,3,2-dioxaphospholane-2-oxideRelated Search:

INDIUM TIN OXIDE Cyclopentyl chloride Phosphorus oxybromide Pralidoxime Chloride Bromocyclopentane Methylcyclopentane ETHYLENE OXIDE Fluroxypyr NITRIC OXIDE Cyclopentane Zinc oxide Chromium(III) oxide (Diethoxymethyl)diphenylphosphine oxide NITROUS OXIDE (4R,5R)-2-CHLORO-4,5-DIMETHYL-1,3,2-DIOXAPHOSPHOLANE 2-OXIDE DIMETHYL PHOSPHOROCHLORIDATE Difluorochloromethane 2-Chloro-1,3,2-dioxaphospholane

Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane)

2-Chloro-1,3-dioxa-2-phosphacyclopentane 2-oxide

Ethylene chlorophosphate, tech. 90%

2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene cycl-chlorophosphate

2-Chloro-1,3,2-dioxaphospholane-2-oxide, Ethylene cycl-chlorophosphate

1,3,2-Dioxaphospholane, 2-chloro-, 2-oxide

CYCLIC CHLOROPHOSPHATE

Ethylene glycol chlorophosphate, 95%

2-Chloro-1,3,2-dioxaphospholane-2-oxide,95%

Ethylene chl

ETHYLENE CHLOROPHOSPHATE

ETHYLENE CYCL-CHLOROPHOSPHATE

2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE

2-CHLORO-1,3,2-DIOXAPHOSPHOLANE-2-OXIDE

2-Chloro-1,2,3-dioxaphospholane-2-oxide

2-Chloro-2-oxo-1,3,2-dioxaphospholane &gt

2-chloro-2-oxo-1,3, 2-dioxophosphorus heterocyclopentane

2-Chloro-1,3,2-dioxaphospholane-2-oxide/ Ethylene Chlorophosphate

2-Chloro-1,3,2-dioxaphospholane-2-oxide (Technical Grade)

2-chloro-1,3,2λ?-dioxaphospholan-2-one

2-chloro-1,3,2

2-chloro-2-oxo-1,3, 2-dioxophosphoheterocyclopentane

2-Chloro-2-Oxido-1,3,2- Dioxaphospholane

6609-64-9

C2H4ClO3P

Organic Building Blocks

Phosphorus Halides

Phosphorus Compounds

Building Blocks

Phosphorylating Agents

DNA / RNA Synthesis

Phosphorylation

Biochemistry

Nucleosides, Nucleotides & Related Reagents

Phosphorylating and Phosphorothioating Agents

Phosphorylation

Protecting Agents, Phosphorylating Agents & Condensing Agents

Synthetic Organic Chemistry