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2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE

Product Name
2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE
CAS No.
426463-09-4
Chemical Name
2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE
Synonyms
2-Chloro-5-iodopyridin-3-aMine;2-chloro-5-iodo-3-pyridinamine;3-AMINO-2-CHLORO-5-IODOPYRIDINE;2-Chloro-3-amino--5-iodopyridine;3-PyridinaMine, 2-chloro-5-iodo-;2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE;2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE ISO 9001：2015 REACH
CBNumber
CB0681601
Molecular Formula
C5H4ClIN2
Formula Weight
254.46
MOL File
426463-09-4.mol
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2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE Property

Melting point:
128-133°C
Boiling point:
352.5±42.0 °C(Predicted)
Density 
2.139±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
0.27±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
720372
Product name
3-Amino-2-chloro-5-iodopyridine
Purity
97%
Packaging
1g
Price
$108
Updated
2023/01/07
Ark Pharm
Product number
AK113412
Product name
2-Chloro-5-iodopyridin-3-amine
Purity
97%
Packaging
25g
Price
$665
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0066602
Product name
3-AMINO-2-CHLORO-5-IODOPYRIDINE
Purity
95.00%
Packaging
1G
Price
$720.98
Updated
2021/12/16
AK Scientific
Product number
5887AB
Product name
2-Chloro-5-iodopyridin-3-amine
Packaging
250mg
Price
$81
Updated
2021/12/16
Crysdot
Product number
CD11125252
Product name
2-Chloro-5-iodopyridin-3-amine
Purity
95+%
Packaging
1g
Price
$100
Updated
2021/12/16
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2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE Chemical Properties,Usage,Production

Synthesis

426463-05-0

426463-09-4

General procedure for the synthesis of 3-amino-2-chloro-5-iodopyridine from 2-chloro-5-iodo-3-nitropyridine: 5-iodo-3-nitro-2-chloropyridine (230 mg, 0.809 mmol), ethanol (1 mL), water (6 drops), and concentrated hydrochloric acid (0.020 mL) were stirred at room temperature for 10 minutes. Subsequently, iron powder (500 mg, 8.95 mmol) was added in small portions and the reaction mixture was heated in an oil bath at 100 °C for 20 min. After completion of the reaction, the iron powder was removed by filtration and the filtrate was washed with ethanol. The ethanol layers were combined and concentrated under reduced pressure. The crude product was purified by fast chromatography using 9:1 hexane:ethyl acetate as eluent to afford 5-iodo-3-amino-2-chloropyridine (190 mg, 92% yield) as a colorless solid with a melting point of 129 °C. 1H NMR (CDCl3) δ (ppm): 4.15 (broad single peak, 2H), 7.34 (double peak, J = 2.0 Hz, 1H), and 7.96 (double peaks, J = 2.0 Hz, 1H); 13C NMR (CDCl3) δ (ppm): 91.41, 129.67, 136.31, 140.77, 143.90. Calculated values for elemental analysis (C5H4N2Cl): C, 23.60; H, 1.58; N, 11.01; Measured values: C, 23.66; H 1.52; N, 10.98.

References

[1] Journal of Organic Chemistry, 2011, vol. 76, # 23, p. 9841 - 9844
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 21, p. 4755 - 4761
[3] Patent: US6538010, 2003, B1
[4] Bioorganic & Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 525 - 528

2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE Suppliers

China 50 India 2 United Kingdom 1 United States 7 Global 60
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Riedel-de Haen AG
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--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
J & W PharmLab, LLC
Tel
--
Fax
--
Email
services@jwpharmlab.com
Country
United States
ProdList
4156
Advantage
63
Anichem LLC
Tel
--
Fax
--
Email
sales@anichemllc.com
Country
United States
ProdList
4112
Advantage
34
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View Lastest Price from 2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE manufacturers

Dideu Industries Group Limited
Product
2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE 426463-09-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-01

426463-09-4, 2-CHLORO-5-IODO-PYRIDIN-3-YLAMINERelated Search:

3-aMino-5-broMo-4-chloropyridine 3-Amino-6-trifluoromethyl-pyridin-2-ol 3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 3-amino-6-chloropyrazine-2-carboxylic acid 3-AMINO-4-METHOXYPYRIDINE 3-AMINO-3-(4-CYANOPHENYL)PROPANOIC ACID 3-Amino-5-chloropyridin-2-ol HCl (3-aminopyrazin-2-yl)methanol 3-Amino-3-(4-methoxyphenyl)propionic acid 3-PYRIDINAMINE, 6-(1-METHYLETHYL)- 3-AMINO-5-HYDROXYBENZOIC ACID 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE 5-IODO-PYRIDIN-3-YLAMINE 2-Chloro-5-iodopyridine 5-CHLORO-3-IODO-PYRIDIN-2-YLAMINE 2-Chloro-5-iodo-3-nitropyridine 2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE 4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE

  • 2-Chloro-5-iodopyridin-3-aMine
  • 2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE
  • 3-PyridinaMine, 2-chloro-5-iodo-
  • 3-AMINO-2-CHLORO-5-IODOPYRIDINE
  • 2-chloro-5-iodo-3-pyridinamine
  • 2-Chloro-3-amino--5-iodopyridine
  • 2-CHLORO-5-IODO-PYRIDIN-3-YLAMINE ISO 9001：2015 REACH
  • 426463-09-4
  • pharmacetical