Human Menopausal Gonadotrophin

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Human Menopausal Gonadotrophin

Product Name: Human Menopausal Gonadotrophin
CAS No.: 61489-71-2
Chemical Name: Human Menopausal Gonadotrophin
Synonyms: HMG;GONADOTROPIN;menotropins;MENOTROPIN;humegon;pergonal;Lepori;Menopur;Menogon;hMG Fuji
CBNumber: CB0685654
Molecular Formula: C9H18O
Formula Weight: 142.23862
MOL File: 61489-71-2.mol

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Human Menopausal Gonadotrophin Property

storage temp.: 2-8°C
InChI: InChI=1S/C9H18O/c1-9(2,3)7-5-4-6-8-10/h8H,4-7H2,1-3H3
InChIKey: CBUWTGCATVNMJE-UHFFFAOYSA-N
SMILES: C(=O)CCCCC(C)(C)C
CAS DataBase Reference: 61489-71-2(CAS DataBase Reference)
EPA Substance Registry System: Menotropins (61489-71-2)

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Safety

Hazard Codes: B
WGK Germany: 3
RTECS: MT6425640

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G5270
Product name: Gonadotropin from human menopausal urine
Packaging: 1MG
Price: $307
Updated: 2022/05/15

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Human Menopausal Gonadotrophin Chemical Properties,Usage,Production

Uses

Gonad-stimulating principle.

Uses

Gonadotropin from human menopausal urine has been used as a supplement in pre-incubated maturation medium for the culture of bovine cumulus oocyte complexes (COCs) to study the effects of multiple freeze-thawing of bovine epididymal sperm on in vitro development of embryo.

brand name

Humegon (Organon); Pergonal (Serono).

General Description

Pituitary hormones prepared from the urine of postmenopausalwomen whose ovarian tissue does not respondto gonadotropin are available for medicinal use as theproduct menotropins (Pergonal). The latter has FSH andLH gonadotropin activity in a 1:1 ratio. Menotropins areuseful in the treatment of anovular women whose ovariesrespond to pituitary gonadotropins but who have a gonadotropindeficiency caused by either pituitary or hypothalamusmalfunction. Usually, menotropins are administeredintramuscularly in an initial dose of 75 IU of FSHand 75 IU of LH daily for 9 to 12 days, followed by 10,000IU of chorionic gonadotropin 1 day after the last dose ofmenotropins.

Biochem/physiol Actions

Gonadotropin interacts with members of the GPCR (G-protein coupled receptor family), and upon activation they induce adenylyl cyclase. This hormone is synthesized in male reproductive tract and has high concentration in semen, especially the a subunit. This subunit is linked with spermatogenesis, and lower levels are present in males with aberrant semen quality.

Clinical Use

Menotropins are a natural product that is obtained from the urine of postmenopausal women and then biologically standardized (international units [IU]) for FSH and LH activities in an approximate ratio of 1:1. Menotropins are used in males with primary (hypothalamic) or secondary (pituitary) hypogonadism to stimulate spermatogenesis, providing they have been treated previously with human chorionic gonadotropin (hCG; a peptide hormone of placental origin that has activity very similar to LH) to effect masculinization (increased testosterone inducing ovulation in women who are having difficulty ovulating as a result of either hypothalamic or pituitary hormonal dysfunction. The menotropins are given for 7 to 12 days, and after clinical evaluation (via ultrasound) indicates the presence of a mature follicle, a single dose of hCG is given to simulate the typical LH surge that normally triggers ovulation. Also, women use the combination of menotropins and hCG to promote the development of multiple follicles when they are participating in an IVF program requiring the recruitment of follicles.

Side effects

Side effects: Headache, mild stomach pain/bloating, redness/pain at the injection site, breast tenderness, or dizziness may occur.
Serious side effects, including: vaginal bleeding, flu-like symptoms (such as fever, chills, joint pain, muscle ache, tiredness).

Human Menopausal Gonadotrophin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Human Menopausal Gonadotrophin manufacturers

CONTIDE BIOTECH CO.,LTD

Product: HMG 61489-71-2
Price: US $0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 5kg
Release date: 2024-04-23

Hebei Kangcang new material Technology Co., LTD

Product: HMG 61489-71-2
Price: US $100.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20ton
Release date: 2024-03-21

Hebei Kangcang new material Technology Co., LTD

Product: HMG 61489-71-2
Price: US $80.00-60.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-03-22

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MENOPAUSAL GONADOTROPHIN, HUMAN URINE

MENOTROPIN

hMG Fuji

Humegon 100

Lepori

Menogon

Menogon HP

Menopur

Merional

Normegon

Ovugraf HP

Pergonal 150

Pergonal 75

Pergovet

Urogonadotropin

HMG

HUMAN MENOPAUSAL GONADOTROPHIN

HUMAN MENOPAUSAL GONADOTROPIN

GONADOTROPIN

GONADOTROPIN, HUMAN MENOPAUSAL URINE

gonadotropin,humanmenopausal

gonadotropin,menopausal

GONADOTROPIN (HMG)

HMG, Menotropins

Human menopausal gonadotropin 61489-71-2 In stock Gonadotropin from human menopausal urine

Gonadotropin from human menopausal urine, >200 I.U. per mg

homogonal

humegon

menopausalgonadotropin

menotropins

neopergonal

pergonal

GONADOTROPIN FROM HUMAN MENOPAUSAL*URINE

MENOPANSAL GONADOTROPIN

Hmg(HumanMenopausalGonadotropin)

GONADOTROPINFROMHUMANMENOPUSALURINE

HUMANMENOPAUSALURINARYGONADOTROPHIN

HMG(HUMAN MENOPAUSAL GONADOTROPHIN)

HUMAN MENOPAUSAL GONADOTROPHIN USP/EP/BP

HMG／Gonadotropin from human menopausal urine

Steroid Hormone H M G

Human Menopausal Gonadotrophin(Sources: Urine from menopausal woman)

Menotropins(HMG)

Gonadotropin CAS

HMG/HMG HUMAN MENOPAUSAL GONADOTROPHIN

61489-71-2

Peptides