ChemicalBook > CAS DataBase List > N-4-Boc-2-piperazinecarboxylic acid

N-4-Boc-2-piperazinecarboxylic acid

Product Name: N-4-Boc-2-piperazinecarboxylic acid
CAS No.: 128019-59-0
Chemical Name: N-4-Boc-2-piperazinecarboxylic acid
Synonyms: 4-BOC-;(4-N-BOC)PIPERAZINE(2R) COOH;4-BOCpiperazin-2-carboxylic acid;4-Boc-2-piperazinecarboxylic acid;4-N-Boc-2-piperazinecarboxylic acid;N4-Boc-piperazine-2-carboxylic acid;N-4-BOC-2-PIPERAZINECARBOXYLIC ACID;4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID;(R)-4-Boc-piperazine-2-carboxylid acid;4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID
CBNumber: CB0693082
Molecular Formula: C10H18N2O4
Formula Weight: 230.26
MOL File: 128019-59-0.mol

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N-4-Boc-2-piperazinecarboxylic acid Property

Melting point:: 231-239 °C
Boiling point:: 371.8±37.0 °C(Predicted)
Density: 1.193±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 2.20±0.20(Predicted)
form: powder or crystals
Appearance: White to off-white Solid
Water Solubility: Slightly soluble in water.
CAS DataBase Reference: 128019-59-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-43-36
Safety Statements: 26-36/37/39-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 676365
Product name: 4-Boc-piperazine-2-carboxylic acid
Packaging: 1g
Price: $74.1
Updated: 2025/07/31

TRC

Product number: B809868
Product name: 4-(tert-Butoxycarbonyl)piperazine-2-carboxylicAcid
Packaging: 10g
Price: $135
Updated: 2021/12/16

Usbiological

Product number: 287262
Product name: N-4-Boc-2-piperazine carboxylic acid
Packaging: 5g
Price: $382
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP30338
Product name: N-4-Boc-2-piperazine carboxylic acid
Packaging: 100g
Price: $450
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 34260
Product name: 4-(tert-Butoxycarbonyl)piperazine-2-carboxylicacid
Purity: 97%
Packaging: 20g
Price: $600
Updated: 2021/12/16

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N-4-Boc-2-piperazinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

As active pharmaceutical drugs and intermediates possess different biological activities.

Synthesis

24424-99-5

3022-15-9

128019-59-0

General procedure for the synthesis of 4-Boc-piperazine-2-carboxylic acid from di-tert-butyl dicarbonate and piperazine-2-carboxylic acid dihydrochloride: sodium bicarbonate (3.1 g, 36.9 mmol) was added to a stirred suspension of piperazine-2-carboxylic acid (5 g, 24.6 mmol) in 1,4-dioxane and water (1:1, 100 mL) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.6 mL, 24.6 mmol) was added slowly at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction mixture was diluted with water (50 mL) and extracted with ether (2 x 100 mL). The aqueous phase was acidified with 2N hydrochloric acid solution and then extracted with n-butanol. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target compound 4-Boc-piperazine-2-carboxylic acid (5 g, 88% yield) as a white solid.1H-NMR (500 MHz, DMSO-d6): δ 10.18 (broad peak, 1H), 4.08 (broad peak, 1H), 3.81-3.71 (multiple peaks, 2H), 3.63 (triple peak, J=6.5Hz, 1H), 3.17-3.15 (multiple peaks, 2H), 2.91-2.86 (multiple peaks, 1H), 1.36 (single peak, 9H), 1.31-1.26 (multiple peaks, 0.5H), 0.87-0.84 (multiple peaks, 0.5H). lcms (esi): m/z 229.0 [M+H]+.

References

[1] Patent: WO2018/26782, 2018, A1. Location in patent: Page/Page column 30-31
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 3, p. 369 - 380

N-4-Boc-2-piperazinecarboxylic acid Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Piperazine-2-carboxylic acid dihydrochloride

Preparation Products

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View Lastest Price from N-4-Boc-2-piperazinecarboxylic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-4-Boc-2-piperazinecarboxylic acid 128019-59-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: N-4-Boc-2-piperazinecarboxylic acid 128019-59-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-13

128019-59-0, N-4-Boc-2-piperazinecarboxylic acidRelated Search:

Piperacillin N-Aminoethylpiperazine Levodropropizine 2-Ethylhexyl ferulate tert-Butyl 1-piperazinecarboxylate Piperazine N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER (R)-1-N-Boc-piperazine-3-carboxylic acid methyl ester N1-FMOC-N4-BOC 2-PIPERAZINECARBOXYLIC ACID,1-FMOC-4-BOC-PIPERAZINE-2-CARBOXYLIC ACID,1-N-FMOC-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (S)-1-N-Boc-piperazine-3-carboxylic acid methyl ester,(S)-N4-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE (S)-1-Boc-piperazine-3-carboxylic acid,(S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID,(S)-1-N-Boc-piperazine-3-carboxylic acid (±)-1-Benzyloxycarbonyl-4-Boc-piperazine-2-carboxylic acid, 97% 1,4-bis-Boc-piperazine-2-carboxylic acid,1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID,1,4-DI-BOC-PIPERAZINE-2-(+/-)-CARBOXYLIC ACID METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE R-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid (S)-N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID (S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID

1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester

(R)-4-Boc-piperazine-2-carboxylid acid

(^+)-4-Boc-piperazine-2-carboxylic acid hydrate, 95%

4-Boc-2-piperazinecarboxylic acid

4-BOCpiperazin-2-carboxylic acid

4-BOC-

4-Boc-piperazine-2-carboxylic acid,1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester

N4-Boc-piperazine-2-carboxylic acid 98%

N4-Boc-piperazine-2-carboxylic acid

4-N-Boc-2-piperazinecarboxylic acid

(^+)-4-Boc-piperazine-2-carboxylicacidhydrate,95%

1,3-Piperazinedicarboxylic acid 1-(tert-butyl) ester

4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid

4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID

4-(TERT-BUTOXYLCARBONYL)-PIPERAZINE-2-CARBOXYLIC ACID

4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID

(4-N-BOC)PIPERAZINE(2R) COOH

1,3-PIPERAZINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER

(R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID

(R)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID

(R)-4-BOC-PIPERAZINE-2-CARBOXYLIC ACID

N-4-BOC-2-PIPERAZINECARBOXYLIC ACID

(R)-PIPERAZINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

(+/-)-4-Boc-piperazine-2-carboxylic acid hydrate

128019-59-0

C10H18N2O4

C10H18N2O4H2O

Heterocyclic Building Blocks

Building Blocks

C10

Chemical Synthesis

pharmacetical

Piperaizine

Piperazines

CR-Y-19