N-4-Boc-2-piperazinecarboxylic acid
- Product Name
- N-4-Boc-2-piperazinecarboxylic acid
- CAS No.
- 128019-59-0
- Chemical Name
- N-4-Boc-2-piperazinecarboxylic acid
- Synonyms
- 4-BOC-;(4-N-BOC)PIPERAZINE(2R) COOH;4-BOCpiperazin-2-carboxylic acid;4-Boc-2-piperazinecarboxylic acid;4-N-Boc-2-piperazinecarboxylic acid;N4-Boc-piperazine-2-carboxylic acid;N-4-BOC-2-PIPERAZINECARBOXYLIC ACID;4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID;(R)-4-Boc-piperazine-2-carboxylid acid;4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID
- CBNumber
- CB0693082
- Molecular Formula
- C10H18N2O4
- Formula Weight
- 230.26
- MOL File
- 128019-59-0.mol
N-4-Boc-2-piperazinecarboxylic acid Property
- Melting point:
- 231-239 °C
- Boiling point:
- 371.8±37.0 °C(Predicted)
- Density
- 1.193±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 2.20±0.20(Predicted)
- form
- powder or crystals
- Appearance
- White to off-white Solid
- Water Solubility
- Slightly soluble in water.
- CAS DataBase Reference
- 128019-59-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43-36
- Safety Statements
- 26-36/37/39-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 676365
- Product name
- 4-Boc-piperazine-2-carboxylic acid
- Packaging
- 1g
- Price
- $74.1
- Updated
- 2025/07/31
- Product number
- B809868
- Product name
- 4-(tert-Butoxycarbonyl)piperazine-2-carboxylicAcid
- Packaging
- 10g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 287262
- Product name
- N-4-Boc-2-piperazine carboxylic acid
- Packaging
- 5g
- Price
- $382
- Updated
- 2021/12/16
- Product number
- OR307034
- Product name
- N4-Boc-piperazine-2-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H58-1-5G
- Product name
- 4-Boc-piperazine-2-carboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
N-4-Boc-2-piperazinecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
As active pharmaceutical drugs and intermediates possess different biological activities.
Synthesis
24424-99-5
3022-15-9
128019-59-0
General procedure for the synthesis of 4-Boc-piperazine-2-carboxylic acid from di-tert-butyl dicarbonate and piperazine-2-carboxylic acid dihydrochloride: sodium bicarbonate (3.1 g, 36.9 mmol) was added to a stirred suspension of piperazine-2-carboxylic acid (5 g, 24.6 mmol) in 1,4-dioxane and water (1:1, 100 mL) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.6 mL, 24.6 mmol) was added slowly at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction mixture was diluted with water (50 mL) and extracted with ether (2 x 100 mL). The aqueous phase was acidified with 2N hydrochloric acid solution and then extracted with n-butanol. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target compound 4-Boc-piperazine-2-carboxylic acid (5 g, 88% yield) as a white solid.1H-NMR (500 MHz, DMSO-d6): δ 10.18 (broad peak, 1H), 4.08 (broad peak, 1H), 3.81-3.71 (multiple peaks, 2H), 3.63 (triple peak, J=6.5Hz, 1H), 3.17-3.15 (multiple peaks, 2H), 2.91-2.86 (multiple peaks, 1H), 1.36 (single peak, 9H), 1.31-1.26 (multiple peaks, 0.5H), 0.87-0.84 (multiple peaks, 0.5H). lcms (esi): m/z 229.0 [M+H]+.
References
[1] Patent: WO2018/26782, 2018, A1. Location in patent: Page/Page column 30-31
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 3, p. 369 - 380
N-4-Boc-2-piperazinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
N-4-Boc-2-piperazinecarboxylic acid Suppliers
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View Lastest Price from N-4-Boc-2-piperazinecarboxylic acid manufacturers
- Product
- N-4-Boc-2-piperazinecarboxylic acid 128019-59-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- N-4-Boc-2-piperazinecarboxylic acid 128019-59-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-13