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(RS)-AMPA

Product Name
(RS)-AMPA
CAS No.
77521-29-0
Chemical Name
(RS)-AMPA
Synonyms
AMPA;C13672;AMPA HBR;(RS)-AMPA;(RS)-AMPA hydrobromi;AMPA (ZWITTERION) POTENT EXCITATORY AMI;5-Methyl-3-hydroxy-α-aminoisoxazole-4-propionic acid;2-AMINO-3-(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPANOIC ACID;2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propanoic acid;(R,S)-A-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
CBNumber
CB0714231
Molecular Formula
C7H10N2O4
Formula Weight
186.17
MOL File
77521-29-0.mol
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(RS)-AMPA Property

Melting point:
240 °C
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: 1.2 mg/mL
pka
2.15±0.10(Predicted)
form 
solid
color 
white
Water Solubility 
Soluble in water (10mM, gentle warming)
Stability:
Hygroscopic
CAS DataBase Reference
77521-29-0
EPA Substance Registry System
.alpha.-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (77521-29-0)
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Safety

WGK Germany 
3
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14571
Product name
(R,S)-AMPA
Purity
≥99%
Packaging
10mg
Price
$119
Updated
2021/12/16
Cayman Chemical
Product number
14571
Product name
(R,S)-AMPA
Purity
≥99%
Packaging
50mg
Price
$536
Updated
2021/12/16
TRC
Product number
A611500
Product name
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicAcid
Packaging
50mg
Price
$430
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0017655
Product name
(R,S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
Purity
95.00%
Packaging
5MG
Price
$498.52
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
6594
Product name
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Hydrobromide
Packaging
10mg
Price
$840
Updated
2021/12/16
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(RS)-AMPA Chemical Properties,Usage,Production

Chemical Properties

White-to-Off White Powder

Uses

A potent and selective agonist of the excitatory neurotransmitter L-glutamic Acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists

Uses

AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Because AMPA does not interfere with binding sites for kainic acid or NMDA , it can be used to distinguish AMPA receptor-specific activity that contributes to a neuronal response. (R,S)-AMPA contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.

Definition

ChEBI: (S)-AMPA is a non-proteinogenic alpha-amino acid.

Biological Activity

More water soluble hydrobromide salt of ( RS )-AMPA ((RS)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid ).

storage

Room temperature

(RS)-AMPA Preparation Products And Raw materials

Raw materials

Preparation Products

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(RS)-AMPA Suppliers

Canada 1 China 19 Germany 2 Switzerland 2 Ukraine 1 United Kingdom 2 United States 15 USA 1 Global 43

77521-29-0, (RS)-AMPARelated Search:

CYCLOTHIAZIDE NBQX DISODIUM SALT KYNURENIC ACID 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE DNQX CNQX (S)-AMPA (RS)-AMPA (RS)-AMPA HYDROBROMIDE

  • 2-AMINO-3-(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPANOIC ACID
  • (RS)-AMPA
  • (R,S)-A-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
  • (RS)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
  • (RS)-ALFA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
  • (R,S)-2-AMINO-3-(3-HYDROXY-5-METHYL-4-ISOXAZOLYL)PROPIONIC ACID
  • AMPA
  • (+/-)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
  • AMPA (ZWITTERION) POTENT EXCITATORY AMI
  • AMPA HBR
  • (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrobromide
  • (r,s)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Hydrobromide
  • (RS)-alpha-Amino-3-hydroxy-5-methyl-4-isoxazol-propionic acid hydrobromide
  • 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propanoic acid
  • 5-Methyl-3-hydroxy-α-aminoisoxazole-4-propionic acid
  • α-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid
  • (S)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid
  • C13672
  • 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid
  • 4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-
  • (RS)-AMPA hydrobromi
  • glutamate,iGluR,neurotransmitter,kainic,Ionotropic glutamate receptors,(RS)-AMPA,NMDA,Inhibitor,CNS,(RS) AMPA,L-glutamic,inhibit,interneurones,Depolarizations,motoneurones,(RS)AMPA
  • 77521-29-0
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Amino Acids and Peptides
  • A - H
  • Biochemicals and Reagents
  • Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • Ligand-Gated Ion Channels
  • Modified Amino Acids
  • Heterocyclic Compounds
  • Neurochemicals
  • Glutamate receptor