ChemicalBook > CAS DataBase List > 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE

1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE

Product Name
1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
CAS No.
5317-33-9
Chemical Name
1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
Synonyms
AKOS BC-0902;CHEMBRDG-BB 4013939;4-METHYL-1-PIPERAZINEPROPANOL;3-(N-METHYLPIPERAZINE)-PROPANOL;1-Piperazinepropanol, 4-methyl-;4-Methyl-1-piperazine-1-propanol;1-(3-Hydroxypropyl)-4-methyl-pipe;3-(N-METHYLPIPERAZINE)-PROPAN-1-OL;3-(4-methyl-1-piperazine)propan-1-ol;3-(4-Methylpiperazin-1-yl)-1-propanol
CBNumber
CB0727644
Molecular Formula
C8H18N2O
Formula Weight
158.24
MOL File
5317-33-9.mol
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1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Property

Melting point:
30 °C
Boiling point:
75-78°C/0.5mm
Density 
0.988±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly)
form 
Solid
pka
15.10±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C8H18N2O/c1-9-4-6-10(7-5-9)3-2-8-11/h11H,2-8H2,1H3
InChIKey
IIXZEUJZLXHPLB-UHFFFAOYSA-N
SMILES
N1(CCCO)CCN(C)CC1
CAS DataBase Reference
5317-33-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
24/25-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M327365
Product name
4-Methyl-1-piperazinepropanol
Packaging
5g
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-XT
Product name
1-(3-Hydroxypropyl)-4-methylpiperazine
Packaging
1g
Price
$55
Updated
2021/12/16
AK Scientific
Product number
W6765
Product name
3-(4-Methylpiperazin-1-yl)propan-1-ol
Packaging
1g
Price
$77
Updated
2021/12/16
Apolloscientific
Product number
OR0881
Product name
1-(3-Hydroxyprop-1-yl)-4-methylpiperazine
Purity
95%
Packaging
5g
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
116070
Product name
3-(N-Methylpiperazine)-propanol
Purity
>90%
Packaging
5g
Price
$10
Updated
2021/12/16
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1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Chemical Properties,Usage,Production

Uses

4-Methyl-1-piperazinepropanol is a useful synthetic organic compound used in the synthesis of S-Alkyl-N-alkylisothiourea compounds.

Synthesis

109-01-3

627-18-9

5317-33-9

General procedure for the synthesis of 1-(3-hydroxypropyl)-4-methylpiperazine from N-methylpiperazine and 3-bromo-1-propanol: Intermediate 7: 3-(4-methylpiperazin-1-yl)-propan-1-ol. Dissolve N-methylpiperazine (6.99 mL, 63 mmol) in toluene (30 mL). 3-Bromo-1-propanol (2.62 mL, 30 mmol) was added slowly and the reaction mixture was stirred at room temperature overnight. Subsequently, the reaction mixture was heated to 80 °C and kept for 2 h, and then cooled to room temperature. The reaction mixture was filtered and the filter cake was washed thoroughly with toluene. After removal of toluene under reduced pressure, the residue was subjected to Kugelrohr distillation (boiling point: 180 °C/2 mbar) to give a colorless oily product (4.08 g, 25.8 mmol, 86% yield). 1H NMR (CDCl3): δ= 1.70 (pseudo quintuple peak, J = 5.8 Hz, 2H), 2.26 (s, 3H), 2.35-2.60 (m, 8H), 2.60 (pseudo triple peak, J = 5.8 Hz, 2H), 3.77 (pseudo triple peak, J = 5.3 Hz, 2H), 4.09 (broad single peak, 1H).

References

[1] Patent: EP1674467, 2006, A1. Location in patent: Page/Page column 26
[2] Patent: EP1674466, 2006, A1. Location in patent: Page/Page column 27
[3] Patent: US2006/142570, 2006, A1. Location in patent: Page/Page column 17
[4] Patent: US2006/135782, 2006, A1. Location in patent: Page/Page column 26
[5] Patent: EP1746096, 2007, A1. Location in patent: Page/Page column 25

1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Suppliers

China 96 Europe 1 France 1 Germany 4 India 4 United Kingdom 9 United States 26 Global 141
A.J Chemicals
Tel
--
Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
--
Fax
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Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
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View Lastest Price from 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE 5317-33-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE 5317-33-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000KGS
Release date
2019-12-19

5317-33-9, 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINERelated Search:

Dropropizine eprozinol 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE 1-Piperazinepropanol Naftopidil dihydrochloride VERRUCULOGEN Doxazosin Centpropazine 1,4-BIS(2-CARBOXYETHYL)PIPERAZINE 1-[3-(3,4-METHYLENEDIOXYPHENOXY)PROPYL]-4-PHENYL-PIPERAZINE MALEATE 3-(4-methylpiperazin-1-yl)propanoic acid 1,4-BIS(2-HYDROXYPROPYL)-2-METHYLPIPERAZINE 3-HYDROXY-1-(IODOMETHYL)-3,8-DIMETHYL-8-AZA-5-AZONIASPIRO[4.5]DECANE IODIDE 1-METHYL-4-OXIRANYLMETHYL-PIPERAZINE 1-(BENZYLOXY)-3-(4-METHYLPIPERAZIN-1-YL)PROPAN-2-OL DIHYDROCHLORIDE ZERENEX ZX000053 1-(4-ETHYLPHENOXY)-3-(4-METHYLPIPERAZIN-1-YL)PROPAN-2-OL DIHYDROCHLORIDE SALOR-INT L120286-1EA

  • 3-(4-METHYL-PIPERAZIN-1-YL)-PROPAN-1-OL
  • 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
  • N-METHYL-N'-(3 HYDROXYLPROPYL) PIPERAZINE
  • 3-(4-methyl-1-piperazine)propan-1-ol
  • 1-Piperazinepropanol,4-methyl-(6CI,7CI,8CI,9CI)
  • 1-(3-HYDROXYPROPYL)-4-METHYL-PIPERAZINE >98%
  • 3-(4-Methylpiperazin-1-yl)-1-propanol
  • 4-Methyl-1-piperazine-1-propanol
  • 3-(4-methyl-1-piperazinyl)propan-1-ol dihydrochloride
  • 3-(4-Methylpiperazin-1-yl)propan-1-ol dihydrochloride
  • 1-(2-hydroxypropyl)-4-methylpiperazine
  • CHEMBRDG-BB 4013939
  • AKOS BC-0902
  • 3-(N-METHYLPIPERAZINE)-PROPAN-1-OL
  • 3-(N-METHYLPIPERAZINE)-PROPANOL
  • 4-METHYL-1-PIPERAZINEPROPANOL
  • 1-(3-Hydroxyprop-1-yl)-4-methylpiperazine
  • 1-Piperazinepropanol, 4-methyl-
  • 1-(3-Hydroxypropyl)-4-methyl-pipe
  • 5317-33-9
  • C8H18N2O
  • pharmacetical
  • piperazines
  • PIPERIDINE