CNQX

Product Name: CNQX
CAS No.: 115066-14-3
Chemical Name: CNQX
Synonyms: CNQX;CNOX;FG-9065;CNQX 2NA;CNQX DISODIUM;CNQX DISODIUM SALT;CNQX disodium salt hydrate;CNQX, AMPA / kainate antagonist;CNQX DISODIUM KAINATE/AMPA RECEPTOR;CNQX (FG-9065) (6-CYANO-7-NITROQUINO
CBNumber: CB0728641
Molecular Formula: C9H4N4O4
Formula Weight: 232.15
MOL File: 115066-14-3.mol

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CNQX Property

Melting point:: 300 °C
Boiling point:: 374.31°C (rough estimate)
Density: 1.5507 (rough estimate)
refractive index: 1.6590 (estimate)
RTECS: VD1520000
storage temp.: protect from light
solubility: H₂O: 10 mg/mL
form: solid
pka: 8.16±0.20(Predicted)
color: orange to red
Stability:: Store Tightly Sealed at RT
CAS DataBase Reference: 115066-14-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C127
Product name: CNQX
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $162
Updated: 2024/03/01

Sigma-Aldrich

Product number: C127
Product name: CNQX
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $546
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.04914
Product name: CNQX - CAS 115066-14-3 - Calbiochem
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Alfa Aesar

Product number: J63472
Product name: 6-Cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione, 98%
Packaging: 10mg
Price: $133.65
Updated: 2024/03/01

Alfa Aesar

Product number: J63472
Product name: 6-Cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione, 98%
Packaging: 25mg
Price: $349.65
Updated: 2024/03/01

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CNQX Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

CNQX disodium salt hydrate has been used as:

as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Uses

A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively

Uses

CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors). This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.

Definition

ChEBI: 6-Cyano-7-nitroquinoxaline-2,3-dione is a quinoxaline derivative.

Biological Activity

Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

storage

Room temperature

CNQX Preparation Products And Raw materials

Raw materials

Preparation Products

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CNQX Suppliers

Belgium 1 Canada 1 China 81 Europe 1 Germany 3 Japan 2 South Korea 1 Switzerland 2 United Kingdom 8 United States 19 USA 1 Global 120

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View Lastest Price from CNQX manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: 6-Cyano-7-Nitroquinoxaline-2,3-Dione 115066-14-3
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-10-31

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 115066-14-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

115066-14-3, CNQXRelated Search:

2-Nitrobenzonitrile N,N'-Dimethyloxalamide 2-HYDROXY-6-METHYLQUINOXALINE 3-Methyl-4-nitroaniline 1,2,3,4-TETRAHYDRO-QUINOXALINE 4-ACETAMIDOBENZONITRILE 2,3-DIHYDROXYQUINOXALINE 3,4-Diaminobenzonitrile 4-ACETAMIDO-2-METHYLNITROBENZENE 6-NITROQUINOXALINE-2,3-DIONE 2,5-Diaminobenzonitrile 1,4-DIHYDRO-6-METHYLQUINOXALINE-2,3-DIONE 6-NITRO-1,2,3,4-TETRAHYDRO QUINOXALINE 4-(N-Methylamino)benzonitrile CNQX N'-METHYL-4-NITROPHENYLENEDIAMINE-(1,2) PYRAZINE-2,3-DIOL N-(4-amino-3-methylphenyl)acetamide

7-Nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile

6-CYANO-7-NITROQUINOXALINE-2,3 (1H,4H)-DIONE

CNQX

CNQX 2NA

CNQX DISODIUM

CNQX DISODIUM SALT

FG-9065

CNQX DISODIUM KAINATE/AMPA RECEPTOR

CNQX (FG-9065) (6-CYANO-7-NITROQUINO

2,3-Dioxo-7-nitroquinoxaline-6-carbonitrile

6-Nitro-7-cyanoquinoxaline-2,3-dione

CNOX

1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile

7-Nitro-2,3-dihydroxyquinoxaline-6-carbonitrile

6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065

6-Cyano-2,3-dihydroxy-7-nitroquinoxaline

6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate

CNQX disodium salt hydrate

7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile

6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 2NA

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM SALT

CNQX,6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065

1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxaline

CNQX, AMPA / kainate antagonist

115066-14-3

486724-17-2

C9H2N4Na2O4

C9H2N4O4Na2

C9H4N4O4

Cell Signaling and Neuroscience

BioChemical

Cell Biology

Ligand-Gated Ion Channels

Ionotropic Glutamate Receptor Modulators

Ion Channels

Heterocyclic Compounds

Neurochemicals

Glutamate receptor

Glutamate

Aromatics

Heterocycles