ChemicalBook > CAS DataBase List > 4-Chloro-3-nitroanisole
4-Chloro-3-nitroanisole
- Product Name
- 4-Chloro-3-nitroanisole
- CAS No.
- 10298-80-3
- Chemical Name
- 4-Chloro-3-nitroanisole
- Synonyms
- 1-CHLORO-4-METHOXY-2-NITROBENZENE;2-CHLORO-5-METHOXYNITROBENZENE;dioxoaMine;Eramod Impurity 2;Iguratimod Impurity 4;Iguratimod Impurity 30;3-NITRO-4-CHLOROANISOLE;4-chloro-3-nitro-anisol;4-CHLORO-3-NITROANISOLE;4-CHLORO-3-NITROANISOLE,98%
- CBNumber
- CB0736059
- Molecular Formula
- C7H6ClNO3
- Formula Weight
- 187.58
- MOL File
- 10298-80-3.mol
More
Less
4-Chloro-3-nitroanisole Property
- Melting point:
- 41-43 °C (lit.)
- Boiling point:
- 293°C
- Density
- 1.366
- refractive index
- 1.6000 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Amber
- BRN
- 640872
- InChI
- InChI=1S/C7H6ClNO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3
- InChIKey
- HISHUMDTGXICEZ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=CC=C(OC)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 10298-80-3(CAS DataBase Reference)
More
Less
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 116289
- Product name
- 4-Chloro-3-nitroanisole
- Purity
- 98%
- Packaging
- 25g
- Price
- $96.4
- Updated
- 2023/06/20
TCI Chemical
- Product number
- C1225
- Product name
- 4-Chloro-3-nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $113
- Updated
- 2025/07/31
TRC
- Product number
- C381703
- Product name
- 4-Chloro-3-nitroanisole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR5423
- Product name
- 4-Chloro-3-nitroanisole
- Packaging
- 100g
- Price
- $82
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4654-5-X9
- Product name
- 4-Chloro-3-nitroanisole
- Packaging
- 100g
- Price
- $96
- Updated
- 2021/12/16
More
Less
4-Chloro-3-nitroanisole Chemical Properties,Usage,Production
Chemical Properties
beige to ochre powder
Uses
4-Chloro-3-nitroanisole can be used as disperse azo dyes.
Uses
4-chloro-3-nitroanisole is used to synthesize a group of derivatives of 7-methanesulfonylamino-6-phenoxychromone at the pyrone and phenoxy rings.
Synthesis
96-96-8
10298-80-3
In a reaction vessel, a concentrated phosphoric acid solution with a mass fraction of 80% and 100 mL of water were added, followed by 4-amino-3-nitroanisole (2) 0.25 mol. The stirring speed was controlled to 230 rpm and the temperature of the solution was lowered to 9 °C. A solution configured from potassium nitrite 0.25 mol dissolved in 100 mL of water was added slowly. A further 200 mL of potassium bisulfite solution with a mass fraction of 55% was added to the reaction vessel, the reaction temperature was maintained at 8 °C, and the reaction lasted for 50 min. 0.30 mol of stannous bromide was dissolved in 130 mL of concentrated potassium chloride solution, and the diazonium salt solution was rapidly added to the stannous bromide solution at 19 °C and allowed to stand for 5 hours. Subsequently, the temperature of the solution was gradually raised to 70 °C until no gas escaped. The distillate was collected by steam distillation and extracted with acetone. The extracts were combined and washed sequentially with sodium bicarbonate solution and potassium chloride solution and finally dehydrated by activated alumina. After recovery of acetone, 43.71 g of yellow solid 4-chloro-3-nitroanisole was obtained in 93% yield.
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] Patent: CN104292107, 2016, B. Location in patent: Paragraph 0030; 0031
[3] Patent: CN105439868, 2016, A. Location in patent: Paragraph 0014; 0015
[4] Tetrahedron Letters, 2010, vol. 51, # 51, p. 6769 - 6771
[5] Organic Process Research and Development, 2017, vol. 21, # 1, p. 44 - 51
4-Chloro-3-nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
4-Chloro-3-nitroanisole Suppliers
- Tel
- 18351236123
- Fax
- QQ：1253649407
- buddychem@foxmail.com
- Country
- China
- ProdList
- 226
- Advantage
- 58
- Tel
- 21-54820552 18964669552
- Fax
- 086-21-64964478
- 188738128@qq.com
- Country
- China
- ProdList
- 310
- Advantage
- 66
- Tel
- 13121959385
- chemrocking@bjgreenchem.com
- Country
- China
- ProdList
- 220
- Advantage
- 58
- Tel
- 020-86211473 13925088720
- linda@aanpharm.com
- Country
- China
- ProdList
- 2944
- Advantage
- 58
- Tel
- 18006124028
- gardepharm@163.com
- Country
- China
- ProdList
- 117
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2816
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11705
- Advantage
- 57
- Tel
- 0519-81291281 18015082300
- Fax
- 0519-81291281
- siduchem@hotmail.com
- Country
- China
- ProdList
- 274
- Advantage
- 62
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 400-188-0725 +86 21 34310725 13611771617
- Fax
- +86 21 34311076
- Country
- China
- ProdList
- 2002
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3199
- Advantage
- 55
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-60451683 15021268886
- Fax
- +86-21-60451682
- sales@arborchemical.com
- Country
- China
- ProdList
- 896
- Advantage
- 55
- Tel
- 021-61995394 18916691159
- chemicalsea@163.com
- Country
- China
- ProdList
- 1972
- Advantage
- 58
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 021-60549325 18616193163
- Fax
- 021-33250306
- Country
- China
- ProdList
- 4526
- Advantage
- 56
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 021-57340939 18017297327
- Fax
- 021-37210791
- sales@gaolangchemical.com
- Country
- China
- ProdList
- 892
- Advantage
- 55
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 13598610367
- Fax
- QQ:2468833170
- 2841375912@qq.com
- Country
- China
- ProdList
- 2788
- Advantage
- 52
- Tel
- 0519-85386832 13382812559
- Fax
- 0519-85386832
- sales@cztrchem.com
- Country
- China
- ProdList
- 1185
- Advantage
- 56
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
More
Less
View Lastest Price from 4-Chloro-3-nitroanisole manufacturers
Hefei Lbao Physical & Chemical Science Co.,Ltd
- Product
- 4-Chloro-3-nitroanisole 10298-80-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-28
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-Chloro-3-nitroanisole 10298-80-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
Henan Aochuang Chemical Co.,Ltd.
- Product
- 4-Chloro-3-nitroanisole 10298-80-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
10298-80-3, 4-Chloro-3-nitroanisoleRelated Search:
Azoic Diazo Component 1
4-Methyl-3-nitroanisole
1-Chloro-3-nitrobenzene
4-Bromo-3-nitroanisole
2-Chloro-3-nitrobenzoic acid
4-CHLORO-3-METHYLANISOLE
2-Methyl-3-nitroanisole
4-Chloro-3-nitrobenzoic acid
4-Nitrobenzoic acid
4-Chloro-3-nitrobenzonitrile
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
Iguratimod Impurity 10
Iguratimod
N-(4-(2-aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride
MethanesulfonaMide, N-[4-[2-(forMylaMino)acetyl]-5-hydroxy-2-phenoxyphenyl]-
Iguratimod Impurity 11
Phenol
Iguratimod Impurity 2