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4-Chloro-3-nitroanisole

Product Name
4-Chloro-3-nitroanisole
CAS No.
10298-80-3
Chemical Name
4-Chloro-3-nitroanisole
Synonyms
1-CHLORO-4-METHOXY-2-NITROBENZENE;2-CHLORO-5-METHOXYNITROBENZENE;dioxoaMine;Eramod Impurity 2;Iguratimod Impurity 4;Iguratimod Impurity 30;3-NITRO-4-CHLOROANISOLE;4-chloro-3-nitro-anisol;4-CHLORO-3-NITROANISOLE;4-CHLORO-3-NITROANISOLE,98%
CBNumber
CB0736059
Molecular Formula
C7H6ClNO3
Formula Weight
187.58
MOL File
10298-80-3.mol
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4-Chloro-3-nitroanisole Property

Melting point:
41-43 °C (lit.)
Boiling point:
293°C
Density 
1.366
refractive index 
1.6000 (estimate)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Amber
BRN 
640872
InChI
InChI=1S/C7H6ClNO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3
InChIKey
HISHUMDTGXICEZ-UHFFFAOYSA-N
SMILES
C1(Cl)=CC=C(OC)C=C1[N+]([O-])=O
CAS DataBase Reference
10298-80-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
BZ8580000
Hazard Note 
Irritant
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
116289
Product name
4-Chloro-3-nitroanisole
Purity
98%
Packaging
25g
Price
$96.4
Updated
2023/06/20
TCI Chemical
Product number
C1225
Product name
4-Chloro-3-nitroanisole
Purity
>98.0%(GC)
Packaging
25g
Price
$113
Updated
2025/07/31
TRC
Product number
C381703
Product name
4-Chloro-3-nitroanisole
Packaging
100mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR5423
Product name
4-Chloro-3-nitroanisole
Packaging
100g
Price
$82
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-5-X9
Product name
4-Chloro-3-nitroanisole
Packaging
100g
Price
$96
Updated
2021/12/16
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4-Chloro-3-nitroanisole Chemical Properties,Usage,Production

Chemical Properties

beige to ochre powder

Uses

4-Chloro-3-nitroanisole can be used as disperse azo dyes.

Uses

4-chloro-3-nitroanisole is used to synthesize a group of derivatives of 7-methanesulfonylamino-6-phenoxychromone at the pyrone and phenoxy rings.

Synthesis

96-96-8

10298-80-3

In a reaction vessel, a concentrated phosphoric acid solution with a mass fraction of 80% and 100 mL of water were added, followed by 4-amino-3-nitroanisole (2) 0.25 mol. The stirring speed was controlled to 230 rpm and the temperature of the solution was lowered to 9 °C. A solution configured from potassium nitrite 0.25 mol dissolved in 100 mL of water was added slowly. A further 200 mL of potassium bisulfite solution with a mass fraction of 55% was added to the reaction vessel, the reaction temperature was maintained at 8 °C, and the reaction lasted for 50 min. 0.30 mol of stannous bromide was dissolved in 130 mL of concentrated potassium chloride solution, and the diazonium salt solution was rapidly added to the stannous bromide solution at 19 °C and allowed to stand for 5 hours. Subsequently, the temperature of the solution was gradually raised to 70 °C until no gas escaped. The distillate was collected by steam distillation and extracted with acetone. The extracts were combined and washed sequentially with sodium bicarbonate solution and potassium chloride solution and finally dehydrated by activated alumina. After recovery of acetone, 43.71 g of yellow solid 4-chloro-3-nitroanisole was obtained in 93% yield.

References

[1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] Patent: CN104292107, 2016, B. Location in patent: Paragraph 0030; 0031
[3] Patent: CN105439868, 2016, A. Location in patent: Paragraph 0014; 0015
[4] Tetrahedron Letters, 2010, vol. 51, # 51, p. 6769 - 6771
[5] Organic Process Research and Development, 2017, vol. 21, # 1, p. 44 - 51

4-Chloro-3-nitroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-3-nitroanisole Suppliers

Americas 1 Belgium 3 China 264 Europe 3 Germany 7 India 34 Japan 4 Russia 1 Slovakia 1 Switzerland 3 Ukraine 1 United Kingdom 15 United States 43 Global 380
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View Lastest Price from 4-Chloro-3-nitroanisole manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
4-Chloro-3-nitroanisole 10298-80-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-28
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Chloro-3-nitroanisole 10298-80-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-10
Henan Aochuang Chemical Co.,Ltd.
Product
4-Chloro-3-nitroanisole 10298-80-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

10298-80-3, 4-Chloro-3-nitroanisoleRelated Search:

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  • 10298-80-3
  • 10289-80-3
  • 10298-80-2
  • 10289-80-3
  • C7H6NO3Cl
  • C7H6CINO3
  • Building Blocks
  • Organic Building Blocks
  • Nitrogen Compounds
  • Nitro Compounds
  • Building Blocks
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • Anisole
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Chlorine Compounds
  • Nitro Compounds
  • FINE Chemical & INTERMEDIATES
  • Miscellaneous