ChemicalBook > CAS DataBase List > 2-Chloro-4,5-diaminopyrimidine

2-Chloro-4,5-diaminopyrimidine

Product Name: 2-Chloro-4,5-diaminopyrimidine
CAS No.: 14631-08-4
Chemical Name: 2-Chloro-4,5-diaminopyrimidine
Synonyms: 2-CHLOROPYRIMIDINE-4,5-DIAMINE;IFLAB-BB F1371-0155;4,5-DIAMINO-2-CHLOROPYRIMIDINE;2-CHLORO-4,5-DIAMINOPYRIMIDINE;6-Chloro-2,3-PyriMidinediaMine;2-CHLORO-4,5-DIAMONOPYRIMIDINE;4,5-Pyrimidinediamine, 2-chloro-;(4-amino-2-chloro-pyrimidin-5-yl)amin;4,5-Pyrimidinediamine, 2-chloro- (9CI);(4-amino-2-chloro-pyrimidin-5-yl)amine
CBNumber: CB0754718
Molecular Formula: C4H5ClN4
Formula Weight: 144.56
MOL File: 14631-08-4.mol

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2-Chloro-4,5-diaminopyrimidine Property

Melting point:: 220 °C (decomp)
Boiling point:: 417.9±25.0 °C(Predicted)
Density: 1.564±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.61±0.10(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C4H5ClN4/c5-4-8-1-2(6)3(7)9-4/h1H,6H2,(H2,7,8,9)
InChIKey: QDUJVEOOSNUDDW-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(N)C(N)=N1
CAS DataBase Reference: 14631-08-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36-43
Safety Statements: 26-36/37
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C363778
Product name: 2-Chloro-4,5-diaminopyrimidine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR17704
Product name: 2-Chloropyrimidine-4,5-diamine
Packaging: 250mg
Price: $38
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-5-Q1
Product name: 2-Chloropyrimidine-4,5-diamine
Packaging: 250mg
Price: $42
Updated: 2021/12/16

ChemScene

Product number: CS-W005962
Product name: 2-Chloropyrimidine-4,5-diamine
Purity: >97.0%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC11903
Product name: 2-Chloro-4,5-diaminopyrimidine
Packaging: 1g
Price: $70
Updated: 2021/12/16

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2-Chloro-4,5-diaminopyrimidine Chemical Properties,Usage,Production

Synthesis

A mixture of 2-chloro-5-nitropyrimidin-4-amine (1.0 g, 5.7 mmol) and SnCl2·2H2O (5.2 g, 22.9 mmol) in EtOH (55 mL) under N2 was heated to 80 °C and stirred for two hours. The mixture was then concentrated under reduced pressure. EtOAc and Celite were added to the residue, and the mixture was basified with saturated Na2CO3 (aq.) to pH 9- 10. The mixture was filtered through a pad of Celite and washed with EtOAc. The organic layer was separated, washed with brine, dried (Na2SO4), and concentrated in a vacuum. The residue was purified on ISCO (20 g silica gel column, EtOAc/hexanes 0~100 per cent) to give 2-Chloro-4,5-diaminopyrimidine (0.41 g 49 per cent).

References

[1] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0544
[2] Patent: WO2016/171755, 2016, A1. Location in patent: Paragraph 0176
[3] Journal of Organic Chemistry, 1955, vol. 20, p. 829,833,835
[4] Nature (London, United Kingdom), 1948, vol. 162, p. 524
[5] Journal of the Chemical Society, 1951, p. 474,478

2-Chloro-4,5-diaminopyrimidine Preparation Products And Raw materials

Raw materials

5-Nitrouracil Ammonium hydroxide Nickel Phosphorus oxitrichloride N,N-Diethylaniline

Preparation Products

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View Lastest Price from 2-Chloro-4,5-diaminopyrimidine manufacturers

Dideu Industries Group Limited

Product: 2-CHLORO-4,5-DIAMINOPYRIMIDINE 14631-08-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-CHLORO-4,5-DIAMINOPYRIMIDINE 14631-08-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-4,5-diamino pyrimidine 14631-08-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

14631-08-4, 2-Chloro-4,5-diaminopyrimidineRelated Search:

2-CHLORO-4,5-DIAMINOPYRIMIDINE 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 2-Chloro-6-methylpyrimidine-4,5-diamine 6-Chloro-4,5-diaminopyrimidine,4-CHLORO-5,6-DIAMINOPYRIMIDINE 4-Chloro-2,6-diaminopyrimidine 4-Chloro-2,6-Diaminopyrimidine-N-Oxide,6-Chloro-2,4-diaminopyrimidine-N-oxide 4,5-Diaminopyrimidine 4-AMINO-2-CHLORO-6-METHYL-5-NITROPYRIMIDINE 2-chloro-N4-methylpyrimidine-4,5-diamine 4-AMINO-2-CHLORO-5-NITRO-6-(METHYLAMINO)PYRIMIDINE 2-chloro-N4-propylpyrimidine-4,5-diamine 4-(6-Amino-2-chloro-5-nitro-4-pyrimidinyl)morpholine 2-CHLORO-5-NITRO-4-METHYL-6-(METHYLAMINO)PYRIMIDINE N4,6-DIMETHYL-N4-PHENYL-2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4-AMINO-2-CHLORO-5-NITRO-6-PIPERIDIN-1-YLPYRIMIDINE 2-CHLORO-4-(2,2-DIPHENYLHYDRAZINO)-5-NITROPYRIMIDINE 2-CHLORO-6-PHENYL-4,5-PYRIMIDINEDIAMINE CHEMBRDG-BB 5145935

IFLAB-BB F1371-0155

2-CHLOROPYRIMIDINE-4,5-DIAMINE

2-CHLORO-4,5-DIAMINOPYRIMIDINE

4,5-DIAMINO-2-CHLOROPYRIMIDINE

(4-amino-2-chloro-pyrimidin-5-yl)amine

4,5-Pyrimidinediamine, 2-chloro- (9CI)

2-CHLORO-4,5-DIAMONOPYRIMIDINE

6-Chloro-2,3-PyriMidinediaMine

(4-amino-2-chloro-pyrimidin-5-yl)amin

4,5-Pyrimidinediamine, 2-chloro-

2-CHLORO-4,5-DIAMINOPYRIMIDINE ISO 9001：2015 REACH

14631-08-4

Heterocycle-Pyrimidine series

PYRIMIDINE

APIs & Intermediate

pharmacetical

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