2-Fluoro-4-methylbenzoic acid

Product Name: 2-Fluoro-4-methylbenzoic acid
CAS No.: 7697-23-6
Chemical Name: 2-Fluoro-4-methylbenzoic acid
Synonyms: RARECHEM AL BO 2237;2-Fluoro-p-toluic Acid;4-Carboxy-3-fluorotoluene;2-Fluoro-4-methylbenzoicaci;2-FLUORO-4-METHYLBENZOIC ACID;2-Fluoro-4-methylbenzoicAcid>Benzoic acid, 2-fluoro-4-methyl-;4-Carboxy-3-fluorotoluene, 2-Fluoro-p-toluic acid
CBNumber: CB0754783
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 7697-23-6.mol

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2-Fluoro-4-methylbenzoic acid Property

Melting point:: 186-189°C
Boiling point:: 271.7±20.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 3.44±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C8H7FO2/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11)
InChIKey: ALFWHEYHCZRVLO-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(C)C=C1F
CAS DataBase Reference: 7697-23-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36-37
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0813
Product name: 2-Fluoro-4-methylbenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: F0813
Product name: 2-Fluoro-4-methylbenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $128
Updated: 2025/07/31

TRC

Product number: F596645
Product name: 2-Fluoro-4-methylbenzoic Acid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC5934
Product name: 2-Fluoro-4-methylbenzoic Acid
Packaging: 25g
Price: $56
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK493415
Product name: 2-Fluoro-4-methylbenzoic Acid
Purity: 97%
Packaging: 1g
Price: $84
Updated: 2021/12/16

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2-Fluoro-4-methylbenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Light yellow to dark yellow solid

Uses

2-Fluoro-4-methylbenzoic Acid is a useful reagent for preparing tubulin inhibitors for antitumor agents.

Synthesis

352-70-5

865-47-4

7697-23-6

Step A: 3-Fluorotoluene (Compound 1, 18.7 g, 170 mmol) was added to a 500 mL three-necked flask under nitrogen protection and cooled to -78 °C. Subsequently, a THF solution of potassium tert-butoxide (11.0 g, 170 mmol) was slowly added via syringe.After 10 min, a pentane solution of tert-butyllithium (19.0 g, 170 mmol) was slowly added via cannula. The reaction mixture was stirred at -78 °C for 2.5 hours. Upon completion of the reaction, the reaction was quenched with a large amount of crushed fresh dry ice, removed from the -78 °C bath and manually stirred with a metal spatula until the dark brown substance was transformed into a light yellow slurry. After 20 minutes of manual mixing, approximately 500 mL of water was added and the reaction mixture continued to be stirred. Subsequently, the reaction mixture was washed with ether (Et2O) and then acidified with 6N hydrochloric acid to pH less than 3 and extracted again with ether. The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give compound 2 (10 g, 45% yield).1H NMR (400 MHz, CDCl3) δ 7.90 (t, 1H), 7.04 (d, 1H), 6.97 (d, 1H), 2.39 (s, 3H).

References

[1] Patent: US2004/176325, 2004, A1. Location in patent: Page/Page column 31; sheet 33

2-Fluoro-4-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Fluoro-4-methylbenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Fluoro-4-methylbenzoic acid 7697-23-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Speranza Chemical Co., Ltd.

Product: 2-fluoro-4-methylbenzoic acid 7697-23-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100MT/Year
Release date: 2024-11-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Fluoro-4-methylbenzoic acid 7697-23-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

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2-Fluoro-4-methylbenzoicaci

7697-23-6

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