Triethylamine hydrochloride Property

Melting point:

261 °C (dec.)(lit.)

Boiling point:

223.18°C (rough estimate)

Density 

1.07

refractive index 

1.4530 (estimate)

storage temp. 

Store below +30°C.

solubility 

1440 g/L (20°C)

form 

Crystalline Powder

color 

White to off-white

PH

5 (10g/l, H2O, 20℃)

Water Solubility 

1440 g/L (20 ºC)

Sensitive 

Hygroscopic

Merck 

14,9666

BRN 

3906409

InChIKey

ILWRPSCZWQJDMK-UHFFFAOYSA-N

CAS DataBase Reference

554-68-7(CAS DataBase Reference)

EPA Substance Registry System

Ethanamine, N,N-diethyl-, hydrochloride (554-68-7)

Safety

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36-36/37/39-22

WGK Germany 

1

RTECS 

YE2111500

F 

3

TSCA 

Yes

HS Code 

29211910

Hazardous Substances Data

554-68-7(Hazardous Substances Data)

Toxicity

LDLo scu-mus: 600 mg/kg JPETAB 37,309,29

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Triethylamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

Triethylamine Hydrochloride is a hydrochloride salt of triethyllamine (T775740). Triethylamine is used as a competing base for the separation of acidic basic and neutral drugs by reverse-phased high-performance liquid chromatography (HPLC). Triethylamine induces visual disturbances (such as foggy vision) in humans, and is also used in industry as a quenching agent in the ozonolysis of alkenes (e.g. (E)-2-Pentene [P227315]). Triethylamine is used in the purification of drugs which are pharmacologically or chemically similar through separation in reverse-phase HPLC (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.

Hazard

Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Targets the central nervous system, liver, kidneys, and heart. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Harmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.

Safety Profile

Moderately toxic by subcutaneousroute. When heated to decomposition it emits toxicvapors of NOx, HCl, and Clí.

Solubility in organics

Soluble in ethanol, chloroform, and alcohol. Insoluble in ether.

Purification Methods

Purify it like the bromide above. [Beilstein 4 IV 327.]

References

[1] C Spagnuolo. “Gel filtration and reactivity of sulphydryl groups of human hemoglobin in concentrated triethylamine hydrochloride solutions.” The Italian journal of biochemistry 21 4 (1972): 221–9.
[2] G. Tian, Qi-Li Yuan, Huanhuan Du. “The Effects of Benzene on the Structure and Properties of Triethylamine Hydrochloride/Chloroaluminate.” Crystals 6 1 (2021).
[3] Zhe Zhang. “Solubility Determination and Model Evaluation of Triethylamine Hydrochloride in Three Binary Mixed Solvents.” Journal of Solution Chemistry 53 10 (2024): 1353–1373.
[4] Junfeng Teng . “Measurement, correlation, and analysis of the solubility of triethylamine hydrochloride in ten pure solvents.” Journal of Molecular Liquids 390 (2023): Article 123040.