ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

Product Name: ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
CAS No.: 28166-41-8
Chemical Name: ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
Synonyms: α-Cyano-4-hydroxycinnamic Acid;ACCA;α-CHCA;A-CYANO-4-HYDROXYCINNAMIC ACID;α-CCA;4-HCCA;α-Cyano;ALPHA-CCA;ALPHA-CHCA;ALPHA-CYANO
CBNumber: CB0781327
Molecular Formula: C10H7NO3
Formula Weight: 189.17
MOL File: 28166-41-8.mol

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ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Property

Melting point:: 245-250 °C(lit.)
Boiling point:: 324.41°C (rough estimate)
Density: 1.3175 (rough estimate)
refractive index: 1.5400 (estimate)
storage temp.: 2-8°C
solubility: methanol: 10 mg/mL, clear
form: powder
pka: 0.85±0.10(Predicted)
color: yellow
Water Solubility: H2O: slightly soluble
methanol: water: soluble
polar organic solvents: soluble
BRN: 3271427
InChI: InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)
InChIKey: AFVLVVWMAFSXCK-VMPITWQZSA-N
SMILES: C(O)(=O)C(C#N)=CC1=CC=C(O)C=C1
CAS DataBase Reference: 28166-41-8(CAS DataBase Reference)
Absorption: ≥2000 at 337nm (mol. absorption)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-23
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 70990
Product name: α-Cyano-4-hydroxycinnamic acid
Purity: matrixsubstanceforMALDI-MS,≥99.0%(HPLC)
Packaging: 250mg
Price: $45.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 70990
Product name: α-Cyano-4-hydroxycinnamic acid
Purity: matrixsubstanceforMALDI-MS,≥99.0%(HPLC)
Packaging: 1g
Price: $125
Updated: 2025/07/31

Sigma-Aldrich

Product number: 39468
Product name: α-Cyano-4-hydroxycinnamic acid
Purity: matrixsubstanceforMALDI-MS,Ultrapure
Packaging: 10x10mg
Price: $349
Updated: 2025/07/31

Sigma-Aldrich

Product number: 145505
Product name: α-Cyano-4-hydroxycinnamic acid
Purity: 97%
Packaging: 5g
Price: $72.39
Updated: 2025/07/31

Sigma-Aldrich

Product number: 145505
Product name: α-Cyano-4-hydroxycinnamic acid
Purity: 97%
Packaging: 25g
Price: $158.65
Updated: 2025/07/31

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ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

inhibitor of mitochondrial pyruvate transport

Uses

α-Cyano-4-hydroxycinnamic acid (CHC) was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

Uses

α-Cyano-4-hydroxycinnamic acid(CHC) was used as a matrix for peptides and nucleotides in mass spectroscopic analysis. It was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

Definition

ChEBI: Alpha-cyano-4-hydroxycinnamic acid is a monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides. It has a role as a MALDI matrix material. It is a nitrile, a member of phenols and a monohydroxycinnamic acid.

General Description

α-Cyano-4-hydroxycinnamic acid is the commonly used matrix for analyzing peptides by matrix-assisted laser desorption/ionization mass spectrometry. It inhibits the monophenolase activity and diphenolase activity of mushroom tyrosinase.

Biochem/physiol Actions

α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport. It is also reported to block β-cell apical anion exchange (IC50 of 2.4 mM).

storage

Store at +4°C

ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Suppliers

Americas 1 Belgium 1 China 147 Europe 2 Germany 3 India 5 Japan 4 Slovakia 1 Switzerland 1 United Kingdom 6 United States 26 USA 1 Global 198

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View Lastest Price from ALPHA-CYANO-4-HYDROXYCINNAMIC ACID manufacturers

Shanghai Qyubiotech Co., Ltd.

Product: a-Cyano-4-hydroxycinnamic acid 28166-41-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%+
Supply Ability: 100000kg per Month
Release date: 2023-08-25

Henan Fengda Chemical Co., Ltd

Product: ALPHA-CYANO-4-HYDROXYCINNAMIC ACID 28166-41-8
Price: US $10.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: ALPHA-CYANO-4-HYDROXYCINNAMIC ACID 28166-41-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

28166-41-8, ALPHA-CYANO-4-HYDROXYCINNAMIC ACIDRelated Search:

ALPHA-CYANO-4-HYDROXYCINNAMIC ACID CDC ALPHA-CYANO-4-METHOXYCINNAMIC ACID 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE 4'-Hydroxy-4-biphenylcarbonitrile N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone 2-CYANO-6-HYDROXYBENZOTHIAZOLE 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE HYDROCHLORIDE 98 Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Ethyl (S)-4-cyano-3-hydroxybutyrate 3-Cyano-6-methyl-2(1H)-pyridinone 2-CYANO-3-HYDROXYPYRIDINE 3-Cyano-4-hydroxybenzoic acid 1-Ethyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 3-Cyano-2-hydroxypyridine 1,2-DIHYDRO-4-(METHOXYMETHYL)-6-METHYL-5-NITRO-2-OXONICOTINONITRILE 2-Cyano-5-hydroxypyridine 5-Hydroxy-2-pyrimidinecarbonitrile

4-HCCA

A-CYANO-4-HYDROXYCINNAMIC ACID

ACCA

ALPHA-CCA

ALPHA-CHCA

ALPHA-CYANO

ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

LABOTEST-BB LT00159295

ALPHA-CYANO-4-HYDROXYCINNAMIC ACID, USE

ALPHA-CYANO-4-HYDROXYCINNAMIC ACID PGE.WITH 10 X 25 MG

alpha-cyano-4-hydroxycinnamate

2-CYANO-3-(4-HYDROXYPHENYL)ACRYLIC ACID

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

2-Cyano-3-(4-hydroxyphenyl)propenoic acid

α-Cyano-4-hydroxybenzenepropenoic acid

alpha-Cyano-4-hydroxycinnamic acid,97%

α-CHCA

2-Cyano-3-(4-hydroxyphenyl)acrylic Acid alpha-CHCA

(E)-2-cyano-3-(4-hydroxyphenyl)acrylic acid

alpha-Cyano-4-hydroxycinnaMic acid 99%

2-Propenoic acid,2-cyano-3-(4-hydroxyphenyl)-

α-cyano-4-hydroxycinnamic acid(α-CHCA)

2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid

2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid

alpha-Cyano-4-hydroxycinnamic acid 28166-41-8

alpha-Cyano-4-hydroxycinnamic acid PRICE

α-Cyano-4-hydroxycinnamic Acid &gt

α-Cyano-4-hydroxycinnamic Acid

α-cyano-4-hydroxycinnamicaci

α-CCA

α-Cyano

alpha-Cyano-4-hydroxycinnamic acid, Ultrapure MALDI Matrix,

2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid (E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid

CHC, Monocarboxylic acid transport inhibitor

α-Cyano-4-hydroxycinnamic acid, 10 mM in DMSO

28166-41-8

HOC6H4CHCCNCO2H

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