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Letolizumab

Product Name
Letolizumab
CAS No.
1450981-87-9
Chemical Name
Letolizumab
Synonyms
Letolizumab;Letolizumab (anti-TNFSF5);Research Grade Letolizumab;Research Grade Letolizumab (DHD85401)
CBNumber
CB08081021
Formula Weight
0
MOL File
Mol file
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Letolizumab Property

form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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Letolizumab Chemical Properties,Usage,Production

Uses

Letolizumab (BMS-986004) is a monoclonal antibody targeting CD40L, which is produced to express mutant IgG1 lacking effector function, including Fc binding and complement fixation. Letolizumab reduces rejection, thromboembolism and prolongs the survival time[1][2][3].

in vivo

Letolizumab inhibits the viability of CD40L trimer and CHO-CD40L in human B cell (IC50 values of 3.6 nM and 1.3 nM, respectively) or nonhuman primate B cell (IC50 values of 3.8 nM and 7.3 nM, respectively)[2].
Letolizumab (2, 10 and 20 mg/kg; i.v.; once a week for 10 weeks) prolongs the survival time of rhesus macaques after renal transplantation[2].

Animal Model:Rhesus macaques after renal transplantation[2].
Dosage:2, 10 and 20 mg/kg.
Administration:Intravenous injection; once a week for 10 weeks.
Result:Increased the survival time.

IC 50

CD40L

References

[1] Karnell JL, et al. Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond. Adv Drug Deliv Rev. 2019 Feb 15;141:92-103. DOI:10.1016/j.addr.2018.12.005
[2] Kim SC, et al. Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection. Am J Transplant. 2017 May;17(5):1182-1192. DOI:10.1111/ajt.14197
[3] Spicer P, et al. Costimulatory pathway targets for autoimmune and inflammatory conditions: clinical successes, failures, and hope for the future. Expert Opin Investig Drugs. 2019 Feb;28(2):99-106. DOI:10.1080/13543784.2019.1557146

Letolizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Letolizumab Suppliers

China 14 Global 14
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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Wuhan Chemstan Biotechnology Co., Ltd.
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027-65317797 15926423062
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QQ：422450190
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422450190@qq.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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24961
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Biolab Reagents
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027-65279366 18108604356
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products@biolabreagent.com
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China
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Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 086-15871494362 13720134139
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orders@jknbiochem.com
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China
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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China
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Changsha Fuzhen Biotechnology Co.，LTD
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0731-13823398 15111215862
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Olix (Shanghai) Pharmaceutical Technology Co., Ltd
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17316404525 17316404525
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209533805@qq.com
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China
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Atagenix Laboratories
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027-87008169 17762441161
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1450981-87-9, LetolizumabRelated Search:

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  • Letolizumab
  • Research Grade Letolizumab (DHD85401)
  • Research Grade Letolizumab
  • Letolizumab (anti-TNFSF5)
  • 1450981-87-9