Amivantamab
- Product Name
- Amivantamab
- CAS No.
- 2171511-58-1
- Chemical Name
- Amivantamab
- Synonyms
- Amivantamab;Amivantamab (anti-c-Met);Research Grade Amivantamab;Research Grade Amivantamab (DHB86907)
- CBNumber
- CB08081157
- Formula Weight
- 0
- MOL File
- Mol file
Amivantamab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
Amivantamab Chemical Properties,Usage,Production
Uses
Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells[1].
in vivo
Amivantamab (JNJ-61186372)(i.p, 30 mg/kg, twice a week, 15 days)effectively reduces tumour volume in female thymus-free BALB-c/nu mouse xenograft model of NSCLC with EGFR Exon20ins mutation and has in vivo anti-tumour effects[2].
References
[1] Keunchil Park, et al. Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study. J Clin Oncol. 2021 Oct 20;39(30):3391-3402. DOI:10.1200/JCO.21.00662
[2] Jiyeon Yun, et al. Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of?EGFR?Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020 Aug;10(8):1194-1209. DOI:10.1158/2159-8290.CD-20-0116
Amivantamab Preparation Products And Raw materials
Raw materials
Preparation Products
Amivantamab Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58