3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
- Product Name
- 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
- CAS No.
- 719268-92-5
- Chemical Name
- 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
- Synonyms
- 5-fluoropyridine-3-borate;5-Fluoropyridinyl-3-boronicacidpinacolate;5-Fluoro-3-pyridylboronic Acid Pinacol Ester;3-FLUOROPYRIDINE-5-BORONIC ACID PINACOL ESTER;5-Fluoropyridin-3-ylboronic acid pinacol ester;3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);(3-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine);2-(5-Fluoro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyri...;3-Fluoro-5-(4,4,5,5-tetraMethy-[1,3,2]dioxaborolan-2-yl)pyridine
- CBNumber
- CB0839978
- Molecular Formula
- C11H15BFNO2
- Formula Weight
- 223.05
- MOL File
- 719268-92-5.mol
3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Property
- Melting point:
- 55.0 to 59.0 °C
- Boiling point:
- 294.5±25.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- powder to crystal
- pka
- 2.80±0.22(Predicted)
- color
- White to Almost white
- InChIKey
- VFMTUTYBMBTIGA-UHFFFAOYSA-N
- CAS DataBase Reference
- 719268-92-5
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SYX00194
- Product name
- 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $475
- Updated
- 2025/07/31
- Product number
- F1026
- Product name
- 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $196
- Updated
- 2025/07/31
- Product number
- F596233
- Product name
- 5-Fluoropyridine-3-boronicacid,pinacolester
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F596233
- Product name
- 5-Fluoropyridine-3-boronicacid,pinacolester
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 8H60-3-13
- Product name
- 5-Fluoropyridine-3-boronic acid, pinacol ester
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production
Synthesis
73183-34-3
462652-75-1
719268-92-5
5-Fluoropyridin-3-yl trifluoromethanesulfonate (3.67 g, 15.0 mmol), potassium acetate (2.94 g, 30.0 mmol), bis(pinacolato)diboron (4.18 g, 17.0 mmol), and dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane (0.37 g, 0.45 mmol) were used in a 45 ml of 1,4-dioxane containing 1% dimethyl sulfoxide, the mixture was degassed with nitrogen for 1 hr and then heated at 90 °C for 14 hrs for the reaction. After completion of the reaction, it was cooled to room temperature and subsequently concentrated under vacuum. To the residue was added 2N sodium hydroxide solution (300 ml), stirred for 10 minutes and filtered. The filtrate was extracted with ether (2 x 200 ml) and the organic phase was discarded. The aqueous phase was cooled to 0°C and the pH was adjusted to 5 by slow dropwise addition of 36% hydrochloric acid over a period of 15 min. The resulting precipitate was allowed to stand at 0°C for 2 h. It was filtered and washed with ice water. The obtained sand-colored solid was dried under vacuum at 300 mmHg in the presence of phosphorus pentoxide to afford 3-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine (3.0 g, 90% yield) as a yellow oil. Its NMR hydrogen spectrum (400 MHz, CDCl3) data were as follows: δH 1.25 (12H, s), 7.75 (1H, dd, J=5Hz and 1Hz), 8.52 (1H, d, J=3Hz), 8.74 (1H, s).
References
[1] Patent: US2004/132767, 2004, A1. Location in patent: Page 11
3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE manufacturers
- Product
- 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 719268-92-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 719268-92-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%
- Supply Ability
- 1000kg
- Release date
- 2023-04-05
- Product
- 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 719268-92-5
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg; 5kg
- Release date
- 2020-02-03