ChemicalBook > CAS DataBase List > Canertinib dihydrochloride

Canertinib dihydrochloride

Product Name
Canertinib dihydrochloride
CAS No.
289499-45-2
Chemical Name
Canertinib dihydrochloride
Synonyms
CI103;CI 103;CI-1033;Canertinib HCl;Canertinib 2HC;Canertinib.2HCL;CI1033 dihydrochloride;CI 1033 dihydrochloride;CI-1033 dihydrochloride;Canertinib (CI-1033) HCl
CBNumber
CB11011729
Molecular Formula
C24H27Cl3FN5O3
Formula Weight
558.86
MOL File
289499-45-2.mol
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Canertinib dihydrochloride Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: >10mg/mL
form 
solid
color 
Light yellow to green yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
UC6316110
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C7249
Product name
CI-1033
Purity
≥98% (HPLC)
Packaging
5mg
Price
$86.8
Updated
2024/03/01
Sigma-Aldrich
Product number
C7249
Product name
CI-1033
Purity
≥98% (HPLC)
Packaging
25mg
Price
$351
Updated
2024/03/01
Cayman Chemical
Product number
12076
Product name
Canertinib (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
12076
Product name
Canertinib (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
12076
Product name
Canertinib (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$134
Updated
2024/03/01
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Canertinib dihydrochloride Chemical Properties,Usage,Production

Uses

CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.

Uses

Canertinib Dihydrochloride is a water-soluble, EGFR, HER2, and ErbB-4 tyrosine kinase inhibitor.

Uses

The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.Canertinib dihydrochloride is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively. As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Canertinib dihydrochloride also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.

Biological Activity

CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4.

storage

Store at -20°C

Canertinib dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Canertinib dihydrochloride Suppliers

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View Lastest Price from Canertinib dihydrochloride manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Canertinib dihydrochloride 289499-45-2
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Canertinib dihydrochloride 289499-45-2
Price
US $23.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-12-16
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Canertinib dihydrochloride 289499-45-2
Price
US $19.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20tons
Release date
2021-12-28

289499-45-2, Canertinib dihydrochlorideRelated Search:

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  • Inhibitors
  • API