Canertinib dihydrochloride

Product Name: Canertinib dihydrochloride
CAS No.: 289499-45-2
Chemical Name: Canertinib dihydrochloride
Synonyms: CI103;CI 103;CI-1033;Canertinib HCl;Canertinib 2HC;Canertinib.2HCL;CI1033 dihydrochloride;CI 1033 dihydrochloride;CI-1033 dihydrochloride;Canertinib (CI-1033) HCl
CBNumber: CB11011729
Molecular Formula: C24H27Cl3FN5O3
Formula Weight: 558.86
MOL File: 289499-45-2.mol

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Canertinib dihydrochloride Property

storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: >10mg/mL
form: solid
color: Light yellow to green yellow

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: UC6316110

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7249
Product name: CI-1033
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $86.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: C7249
Product name: CI-1033
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $351
Updated: 2024/03/01

Cayman Chemical

Product number: 12076
Product name: Canertinib (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 12076
Product name: Canertinib (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 12076
Product name: Canertinib (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $134
Updated: 2024/03/01

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Canertinib dihydrochloride Chemical Properties,Usage,Production

Uses

CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.

Uses

Canertinib Dihydrochloride is a water-soluble, EGFR, HER2, and ErbB-4 tyrosine kinase inhibitor.

Uses

The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.Canertinib dihydrochloride is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively. As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Canertinib dihydrochloride also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.

storage

Store at -20°C

Canertinib dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Canertinib dihydrochloride Suppliers

China 114 Germany 1 India 6 The Netherlands 1 United Kingdom 3 United States 19 Global 144

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9809
Advantage: 59

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Xi’an chemsoar Medical Technology Co., ltd

Tel: 029-86538357
Fax: 029-87871708
Country: China
ProdList: 234
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

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View Lastest Price from Canertinib dihydrochloride manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Canertinib dihydrochloride 289499-45-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Canertinib dihydrochloride 289499-45-2
Price: US $23.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 ton
Release date: 2021-12-16

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Canertinib dihydrochloride 289499-45-2
Price: US $19.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20tons
Release date: 2021-12-28

289499-45-2, Canertinib dihydrochlorideRelated Search:

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CANERTINIB DIHYDROCHLORIDE

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride

Canertinib Dihydrochloride (CI-1033 HCl)

Canertinib (CI-1033) HCl

CANERTINIB;CI-1033 DIHYDROCHLORIDE;PD-183805 DIHYDROCHLORIDE;CI1033 DIHYDROCHLORIDE;CI 1033 DIHYDROCHLORIDE;PD183805 DIHYDROCHLORIDE;PD 183805 DIHYDROCHLORIDE

Canertinib dihydrochloride (CI-1033

Canertinib.2HCL

CI-1033

N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride

Canertinib HCl

CI 103

CI103

PD-183805 dihydrochloride

Canertinib dihydrochloride/Canertinib

CI 1033 dihydrochloride

CI1033 dihydrochloride

CI-1033 dihydrochloride

Canertinib dihydrochloride N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride

N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide dihydr

Canertinib (CI-1033) 2HCl

Canertinib (hydrochloride)

Canertinib (CI-1033) dihydrochloride

Canertinib 2HC

Canertinib dihydrochloride USP/EP/BP

2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-, hydrochloride (1:2)

289499-45-2

C24H25ClFN5O32HCl

C24H27Cl3FN5O3

Inhibitors

API