3,4-Dimethoxycinnamic acid
- Product Name
- 3,4-Dimethoxycinnamic acid
- CAS No.
- 2316-26-9
- Chemical Name
- 3,4-Dimethoxycinnamic acid
- Synonyms
- Caffeic acid dimethyl ether;(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid;DIMETHYLCAFFEIC ACID;3-(3,4-DIMETHOXYPHENYL)-2-PROPENOIC ACID;AURORA 2809;AKOS BB/0042;3,4-Dimethoxy;AKOS BBS-00000090;Methylferulic acid;TIMTEC-BB SBB005722
- CBNumber
- CB1119956
- Molecular Formula
- C11H12O4
- Formula Weight
- 208.21
- MOL File
- 2316-26-9.mol
3,4-Dimethoxycinnamic acid Property
- Melting point:
- 181-183 °C(lit.)
- Boiling point:
- 267.4°C (rough estimate)
- Density
- 1.0627 (rough estimate)
- refractive index
- 1.4389 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Solubility in hot methanol, very faint turbidity. Soluble in dichloromethane, chloroform.
- form
- Powder
- pka
- 4.53±0.10(Predicted)
- color
- Slightly yellow to light beige
- BRN
- 1533435
- InChI
- InChI=1S/C11H12O4/c1-14-9-5-3-8(4-6-11(12)13)7-10(9)15-2/h3-7H,1-2H3,(H,12,13)
- InChIKey
- HJBWJAPEBGSQPR-GQCTYLIASA-N
- SMILES
- C(O)(=O)C=CC1=CC=C(OC)C(OC)=C1
- LogP
- 2.340
- CAS DataBase Reference
- 2316-26-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 3,4-Dimethoxycinnamic acid(2316-26-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D133809
- Product name
- 3,4-Dimethoxycinnamic acid, predominantly trans
- Purity
- 99%
- Packaging
- 25g
- Price
- $72.5
- Updated
- 2025/07/31
- Product number
- D1728
- Product name
- 3,4-Dimethoxycinnamic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- D473695
- Product name
- 3,4-Dimethoxycinnamic Acid
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D473695
- Product name
- 3,4-Dimethoxycinnamic Acid
- Packaging
- 2.5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- J52053
- Product name
- 3,4-Dimethoxycinnamic Acid
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
3,4-Dimethoxycinnamic acid Chemical Properties,Usage,Production
Chemical Properties
Slightly yellow to light beige powder
Uses
3,4-Dimethoxycinnamic Acid is a Cinnamic Acid (C442030) derivative,used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines and N-methylation of amides and O-methylation of carboxylic acids.
Definition
ChEBI: 3,4-dimethoxycinnamic acid is a methoxycinnamic acid that is trans-cinnamic acid substituted by methoxy groups at positions 3' and 4' respectively. It is functionally related to a trans-cinnamic acid.
Synthesis
141-82-2
120-14-9
2316-26-9
GENERAL METHOD: In a dry reaction vessel, veratraldehyde (500 mg, 1.0 eq.) and malonic acid (981 mg, 2.0 eq.) were dissolved in dimethylformamide (5 mL), followed by the addition of DABCO (105 mg, 0.2 eq.). The reaction mixture was stirred at 100-110°C for 60-90 min. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was slowly poured into ice water and extracted with ethyl acetate (3 x 10 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by recrystallization from a chloroform/hexane solvent mixture to afford 3,4-dimethoxycinnamic acid in good yield.
References
[1] Organic Letters, 2016, vol. 18, # 5, p. 1182 - 1185
[2] Oriental Journal of Chemistry, 2012, vol. 28, # 4, p. 1725 - 1728
[3] Asian Journal of Chemistry, 2017, vol. 29, # 7, p. 1561 - 1564
[4] Journal of Heterocyclic Chemistry, 1987, vol. 24, # 6, p. 1589 - 1594
[5] RSC Advances, 2015, vol. 5, # 34, p. 26596 - 26603
3,4-Dimethoxycinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3,4-Dimethoxycinnamic acid Suppliers
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- --
- Fax
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- chemcontrol@nextra.sk
- Country
- Slovakia
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- 6700
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View Lastest Price from 3,4-Dimethoxycinnamic acid manufacturers
- Product
- 3,4-Dimethoxycinnamic acid 2316-26-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-01
- Product
- 3,4-Dimethoxycinnamic acid 2316-26-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- 3, 4-Dimethoxycinnamic Acid 2316-26-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10 ton
- Release date
- 2024-08-20