ChemicalBook > CAS DataBase List > 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

Product Name: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
CAS No.: 6969-71-7
Chemical Name: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
Synonyms: 2H-[1,2,4]triazolo[4,3-a]pyridin-3-one;1,2,4-TRIAZOLO-[4,3-A]PYRIDINE-3(2H)-ONE;NSC 68462;Pyridotriazolone;Pyridyltriazolone;Pyridinotriazolone;Triazolo Pyridinone;1,2,4-Triazolo[4,3-a;Pyridine triadiMefon;Trazodone Impurity 15
CBNumber: CB1120921
Molecular Formula: C6H5N3O
Formula Weight: 135.12
MOL File: 6969-71-7.mol

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1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Property

Melting point:: 231°C
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka: 7.86±0.20(Predicted)
form: Solid
color: Light Brown to Brown
BRN: 607433
Stability:: Light Sensitive
InChI: InChI=1S/C6H5N3O/c10-6-8-7-5-3-1-2-4-9(5)6/h1-4H,(H,8,10)
InChIKey: LJRXNXBFJXXRNQ-UHFFFAOYSA-N
SMILES: C12=NNC(=O)N1C=CC=C2
LogP: 0.113
CAS DataBase Reference: 6969-71-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 736821
Product name: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
Purity: 97%
Packaging: 25g
Price: $62.9
Updated: 2022/05/15

TCI Chemical

Product number: T1667
Product name: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $46
Updated: 2025/07/31

TRC

Product number: T767505
Product name: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
Packaging: 25g
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 468025
Product name: Triazolopyridinone
Packaging: 100mg
Price: $460
Updated: 2021/12/16

TRC

Product number: T767505
Product name: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
Packaging: 250g
Price: $470
Updated: 2021/12/16

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1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one was used to prepare a congener of Trazodone (T718500) which was found to be a potent and selective inhibitor of synaptosomal uptake of 5-hydroxytryptamine.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 28, p. 1394, 1985 DOI: 10.1021/jm00148a004

Synthesis

109-09-1

563-41-7

6969-71-7

General procedure for the synthesis of [1,2,4]triazolo[4,3-a]pyridin-3-(2H)-one from 2-chloropyridine and aminourea hydrochloride: 2-chloropyridine (5.0 g, 44.03 mmol), aminourea hydrochloride (9.8 g, 88.06 mmol), and 2-ethoxyethanol (15 mL) were mixed and heated to reflux. Concentrated hydrochloric acid (0.1 mL dissolved in 1 mL of 2-ethoxyethanol) was slowly added to the reaction mixture. The reaction was kept at reflux for 24 hours and subsequently cooled to about 60 °C and diluted with deionized water (15 mL). The resulting light yellow solid product was collected by filtration and washed with deionized water to afford the title compound (2.2 g, 51% yield). The melting point of the product was 235-240°C. 1H NMR (300 MHz, DMSO-d6) δ 6.51-6.60 (m, 1H), 7.05-7.22 (m, 2H), 7.80 (d, J=7.1 Hz, 1H), 12.45 (br, 1H, exchangeable with D2O); IR (KBr) ν 3173, 3098. 3048, 1717, 1634, 1536, 1348 cm-1; MS 136 (M+1).

References

[1] Patent: US2009/209550, 2009, A1. Location in patent: Page/Page column 25-26
[2] Patent: US4254124, 1981, A

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Preparation Products And Raw materials

Raw materials

Pyridine

Preparation Products

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View Lastest Price from 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one manufacturers

Dideu Industries Group Limited

Product: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one 6969-71-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one 6969-71-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one 6969-71-7
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10MT
Release date: 2018-12-21

6969-71-7, 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-oneRelated Search:

Sulfasalazine Furazolidone Sodium Pyrithione Chromium picolinate Triadimefon Zinc pyrithione Trazodone 4-Methylpyridine Pyridine 2-Pyridinecarboxaldehyde Pyridine hydrochloride Pyridine sulfur trioxide Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 6-BROMO-1,2,4-TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE Trazodone hydrochloride 4-HYDROXYPYRIDINE 2-(3-CHLOROPROPYL)-1,2,4-TRIAZOL-[4,3-A]PYRIDINE-3 (2H)-ONE 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl-d6]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one Hydrochloride

1,2,4-TRIAZOLO-[4,3-A]PYRIDINE-3(2H)-ONE

1,2,4-TRIAZOLE(4,3)PYRIDIN-3-(2H)-ONE

1,2,4-TRIAZOL-(4,3-A)-PYRIDINE 3 (2H)-ONE

1,2,4-Triazolopyridin-3-one

3-HYDROXYTRIAZOLO[4,3-A]PYRIDINE

3-HYDROXY-1,2,4-TRIAZOLO[4,3-A]PYRIDINE

1,2,4-Triazole-(4,3-alpha)pyri

Trazodone Impurity 15

2,4-Triazolopyridin-3-one

Triazolo Pyridinone

2H-[1,2,4]triazolo[4,3-a]pyridin-3-one

1,2,4-Triazole-(4,3-a) Pyridine-3 (2H) - One

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 98+%

1,2,4-Triazolo4,3-aüpyridin-3(2H)-one, 98+%

1,2,4-TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE

1,2,4-Triazolo[4,3-a

Pyridine triadiMefon

1,2,4-trizolo(4,3a)pyridine-3(2H)-one

1,2,4-Triazol-[4,3-a]-pyridin-3(2H)-one

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one 97%

1,2,4-Triazolo[4,3-<i>a</i>]pyridin-3(2<i>H</i>)-one

NSC 68462

s-Triazolo[4,3-a]pyridin-3-ol

1,2,4-Triazolo[4,3-a]pyridin-3(H)-one

2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one

Pyridine threeTriadiMefon

1,2,4-Triazolo[4,3-a]pyridine-3(2H)

Trazodone Triazolopyridinone

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one ISO 9001：2015 REACH

[1,2,4] TRIAZOLO [4,3-A] PYRIDIN-3(2H)-ONE ( TPO )

1,2,4-TRIAZOLO-[4,3-α]-PYRIDIN-3(2H)-ONE

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one (9CI, ACI)

1,2,4 triazolo[4,3-a pyridine-3(2H)-Onesodium (TDI)

1,2,4]triazolo[4,3-a]pyridine-3(2H)-Onesodium

Pyridinotriazolone

1,2,4]triazolo[4,3-a]pyridin-3-one

Pyridotriazolone

Pyridine Triazolone (trazodone impurity 4)

Pyridyltriazolone

Trazodone Impurity 15 (Trazodone Hydrochloride EP Impurity K)

Trazodone EP Impurity K (Triazolopyridinone)

6969-71-7

6967-71-7

C6H5N3O

Heterocycles

intermediate for some organic synthesis

Fused Ring Systems

Pyridines

APIs & Intermediate

Pyrimidine