1-Butanesulfonyl chloride Property

Melting point:

-29°C

Boiling point:

80-81 °C/9 mmHg (lit.)

Density 

1.208 g/mL at 25 °C (lit.)

vapor pressure 

0.5 mm Hg ( 20 °C)

refractive index 

n20/D 1.454(lit.)

Flash point:

175 °F

form 

Liquid

color 

Clear colorless to light yellow or light orange

Water Solubility 

DECOMPOSES

Sensitive 

Moisture Sensitive

BRN 

1748742

InChIKey

WEDIIKBPDQQQJU-UHFFFAOYSA-N

CAS DataBase Reference

2386-60-9(CAS DataBase Reference)

NIST Chemistry Reference

1-Butanesulfonyl chloride(2386-60-9)

EPA Substance Registry System

1-Butanesulfonyl chloride (2386-60-9)

Safety

Hazard Codes 

C

Risk Statements 

34-36/37

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

RTECS 

EK5950000

F 

10-19-21

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29049090

Toxicity

mouse,LD50,intraperitoneal,> 100mg/kg (100mg/kg),Nature. Vol. 174, Pg. 737, 1954.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H335May cause respiratory irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P370+P378In case of fire: Use … for extinction.

P390Absorb spillage to prevent material damage.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

1-Butanesulfonyl chloride Chemical Properties,Usage,Production

Description

1-Butanesulfonyl chloride is an antimicrobial agent that inhibits the production of inflammatory substances. It has been shown to inhibit acetylcholinesterase activity and the growth of cancer cells in vitro. 1-Butanesulfonyl chloride is a cross-linking agent that can be used to produce amides, which are used as pharmaceutical preparations for treating inflammatory diseases.

Chemical Properties

clear colourless to light yellow liquid

Uses

1-Butanesulfonyl chloride has been used in the preparation of:

• ethyl 2-(1-butanesulfonamido)pent-4-yn-l-oate
• 1-butanesulfonamid-N,N′-1,2-ethanediylbis
• 1-butanesulfonamide-N,N′-1,3-propanediylbis

Purification Methods

It has a pungent odour and is LACHRYMATORY. If IR shows OH bands, then dissolve in Et2O, wash with cold saturated aqueous NaHCO3 (care since CO2 will be generated) then H2O, dry it over solid Na2SO4, filter, evaporate and distil the residue twice. Characterise it by shaking a solution in Et2O or *C6H6 with aqueous NH3, collect the solid 1-butanesulfonamide with m 48o after recrystallisation from CHCl3, CCl4 or Et2O/pet ether. [Douglass & Johnson J Am Chem Soc 60 1488 1938, Lee & Dougherty J Org Chem 5 83 1940, Beilstein 4 IV 45.]