ChemicalBook > CAS DataBase List > 5-Bromoisatin

5-Bromoisatin

Product Name
5-Bromoisatin
CAS No.
87-48-9
Chemical Name
5-Bromoisatin
Synonyms
5-BROMOINDOLINE-2,3-DIONE;BromoIsatin;5-bromisatin;5-BROMO-3-CHLORO-2-METHYLPYRIDINE;NSC 4980;AKOS B028934;5-BROMOISATIN;5-bromo-isati;AKOS BBS-00000997;Reaxys ID: 383760
CBNumber
CB1142138
Molecular Formula
C8H4BrNO2
Formula Weight
226.03
MOL File
87-48-9.mol
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5-Bromoisatin Property

Melting point:
247-252 °C (lit.)
Density 
1.7498 (rough estimate)
refractive index 
1.6120 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in N,N dimethylformamide.
pka
8.74±0.20(Predicted)
form 
Crystalline Powder
color 
Orange
BRN 
383760
InChIKey
MBVCESWADCIXJN-UHFFFAOYSA-N
CAS DataBase Reference
87-48-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-36/39-37/39-36
RIDADR 
2811
WGK Germany 
2
RTECS 
NL7875000
Hazard Note 
Irritant
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
476994
Product name
5-Bromoisatin
Purity
technical grade, 90%
Packaging
5g
Price
$17.82
Updated
2024/03/01
Sigma-Aldrich
Product number
476994
Product name
5-Bromoisatin
Purity
technical grade, 90%
Packaging
25g
Price
$106
Updated
2024/03/01
TCI Chemical
Product number
B1566
Product name
5-Bromoisatin
Purity
>97.0%(HPLC)(T)
Packaging
25g
Price
$143
Updated
2024/03/01
TCI Chemical
Product number
B1566
Product name
5-Bromoisatin
Purity
>97.0%(HPLC)(T)
Packaging
250g
Price
$714
Updated
2024/03/01
Alfa Aesar
Product number
A13641
Product name
5-Bromoisatin, 90+%
Packaging
50g
Price
$67.65
Updated
2024/03/01
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5-Bromoisatin Chemical Properties,Usage,Production

Chemical Properties

Orange crystalline powder

Uses

5-Bromoisatin is used in the synthesis of N-derivatives of 5-bromoisatin, N-substituted pyrroles, linear polyaryleneoxindoles, 5-bromodioxindole, cinchoninic acid derivatives, 3-hydroxyoxindole, S-benzyldithiocarbazate Schiff Bases, 5-bromooxindole and Morita-Baylis-Hillman adducts of isatin derivatives. It is an indole derivative.

Definition

ChEBI: 5-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 3099, 1984 DOI: 10.1016/0040-4039(84)80017-9

General Description

5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO2. Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs. It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice.

Purification Methods

5-Bromoisatin forms red prisms or needles from EtOH. The N-acetate crystallises as yellow prisms from *C6H6, m 170-172o, and the N-methyl derivative forms orange-red needles from MeOH, m 172-173o. [Heller Chem Ber 53 1545 1920, Buu-Hoi Recl Trav Chim, Pays-Bas 73 197 1954, Baker etal. Tetrahedron Lett 215 1978, Beilstein 21 H 453, 21 III/IV 5009.]

5-Bromoisatin Preparation Products And Raw materials

Raw materials

Preparation Products

6-BROMO-3-HYDROXYQUINOLINE
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5-Bromoisatin Suppliers

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View Lastest Price from 5-Bromoisatin manufacturers

Honest Joy Holdings Limited
Product
5-Bromoisatin 87-48-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.9%
Supply Ability
100 tons
Release date
2022-02-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-Bromoisatin 87-48-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
5-Bromoisatin 87-48-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

87-48-9, 5-BromoisatinRelated Search:

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  • NSC 4980
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  • 5-BROMO-3-CHLORO-2-METHYLPYRIDINE
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  • Reaxys ID: 383760
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  • BUTTPARK 50\07-94
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  • 87-48-9
  • C8H4BrNO2xH2O
  • C8H4BrNO2
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
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  • ARYL HALIDE
  • Building Blocks
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  • Heterocycles
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  • Heterocyclic Building Blocks
  • IndolesBuilding Blocks