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ChemicalBook > CAS DataBase List > 5-Fluoro-2-picolinic acid

5-Fluoro-2-picolinic acid

Uses
Product Name
5-Fluoro-2-picolinic acid
CAS No.
107504-08-5
Chemical Name
5-Fluoro-2-picolinic acid
Synonyms
5-FLUOROPICOLINIC ACID;5-FLUOROPYRIDINE-2-CARBOXYLIC ACID;EOS-60510;5-Fluoropicolinicaci;5-FLUORO-2-PICOLINIC ACID;5-Fluoropyridine-2-carboxylic;2-carboxylate - 5-fluoropyridine;5-Fluoropyrdine-2-carboxylic acid;5-fluoropyridin-2-carboxylic acid;5-Fluoropyridin-2-ylpicolinicacid
CBNumber
CB1143357
Molecular Formula
C6H4FNO2
Formula Weight
141.1
MOL File
107504-08-5.mol
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5-Fluoro-2-picolinic acid Property

Melting point:
164-166℃
Boiling point:
275.1±20.0 °C(Predicted)
Density 
1.419±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
3.58±0.10(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C6H4FNO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10)
InChIKey
JTKFIIQGMVKDNZ-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=NC=C(F)C=C1
CAS DataBase Reference
107504-08-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0838
Product name
5-Fluoro-2-pyridinecarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
F0838
Product name
5-Fluoro-2-pyridinecarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$150
Updated
2025/07/31
TRC
Product number
F621140
Product name
5-Fluoropicolinicacid
Packaging
1g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC5246
Product name
5-Fluoropyridine-2-carboxylicacid
Purity
98%
Packaging
25g
Price
$98
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
F11153
Product name
5-Fluoropyridine-2-carboxylicacid
Purity
95%
Packaging
25g
Price
$120
Updated
2021/12/16
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5-Fluoro-2-picolinic acid Chemical Properties,Usage,Production

Uses

5-Fluoro-2-pyridinecarboxylic acid, a common organic synthetic intermediate, is mainly used for the structural modification and derivatization of pyridine-containing drug molecules and bioactive molecules. The carboxyl group on the pyridine ring can be converted to an ester group, but acid-promoted esterification is generally not used. A more common approach is to first convert the carboxyl group to an acyl chloride using sulfoxide, followed by the addition of an alcohol to convert it to an ester group. Furthermore, the carboxyl group on this compound can also be converted to a trifluoromethyl group. Finally, the nitrogen atom on the pyridine ring can also be oxidized to nitrogen oxides.

Synthesis

Potassium phosphate monobasic (1.4 g, 10 mmol) in water (10 mL) was added to a solution of 5-fluoropyridine-2-carbaldehyde (0.50 g, 4.0 mmol, Frontier) in DMSO (10 mL). Sodium chlorite (0.9 g, 0.008 mol) in water (10 mL) was added, and the reaction continued for 1 hour. The mixture was saturated with NaCl, then diluted with EtOAc. The organic layer was further washed with brine, dried over sodium sulfate and concentrated to afford 5-FLUORO-2-PICOLINIC ACID (370 mg, 65%).

References

[1] Patent: WO2011/28685, 2011, A1. Location in patent: Page/Page column 85; 86

5-Fluoro-2-picolinic acid Preparation Products And Raw materials

Raw materials

Hexane Nitrogen Ammonium formate 2,2,6,6-Tetramethylpiperidine Chlorotrimethylsilane Carbon dioxide 3-Fluoropyridine 2-Dimethylaminoethanol Tetrahydrofuran Hydrochloric acid Methanol 1,1,2-Trichlorotrifluoroethane Tetrabutylammonium fluoride HEAVY DISTILLATE n-Butyllithium

Preparation Products

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5-Fluoro-2-picolinic acid Suppliers

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Ark Pharm, Inc.
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View Lastest Price from 5-Fluoro-2-picolinic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Fluoro-2-picolinic acid 107504-08-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-03
Henan Aochuang Chemical Co.,Ltd.
Product
5-FLUORO-2-PICOLINIC ACID 107504-08-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Henan Fengda Chemical Co., Ltd
Product
5-FLUORO-2-PICOLINIC ACID 107504-08-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

107504-08-5, 5-Fluoro-2-picolinic acidRelated Search:

3,5-Difluoro-2-pyridinecarboxylic acid 2-Fluoronicotinic acid 5-AMINO-2-FLUORO-ISONICOTINIC ACID 3,5-Difluoropicolinic acid 5-FLUORO-6-METHYLPYRIDINE-2-CARBOXYLIC ACID 5,6-Difluoropyridine-2-carboxylic acid 5,6-Difluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid 5-FLUORO-2-PICOLINIC ACID

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