ChemicalBook > CAS DataBase List > 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid

4-[(tert-Butoxycarbonylamino)methyl]benzoic acid

Product Name
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
CAS No.
33233-67-9
Chemical Name
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid
Synonyms
BOC-PAMB;BOC-AMB-OH;BOC-PAMB-OH;BOC-4-AMB-OH;BOC-(4)AMBZ-OH;AKOS BBS-00000218;BOC-HN-CH2-PH(4)-COOH;BOC-P-AMINOMETHYLBENZOIC ACID;(Tert-Butoxy)Carbonyl 4-Amb-OH;4-(BOC-AMINOMETHYL)BENZOIC ACID
CBNumber
CB1143731
Molecular Formula
C13H17NO4
Formula Weight
251.28
MOL File
33233-67-9.mol
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4-[(tert-Butoxycarbonylamino)methyl]benzoic acid Property

Melting point:
164-168 °C
Boiling point:
427.8±38.0 °C(Predicted)
Density 
1.178±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
4.25±0.10(Predicted)
form 
Crystalline
color 
Off-white
BRN 
2854286
CAS DataBase Reference
33233-67-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
04060
Product name
4-(Boc-aminomethyl)benzoic acid
Purity
≥98.0% (T)
Packaging
5g
Price
$90.5
Updated
2025/07/31
Sigma-Aldrich
Product number
04060
Product name
4-(Boc-aminomethyl)benzoic acid
Purity
≥98.0% (T)
Packaging
1g
Price
$52.9
Updated
2023/06/20
TCI Chemical
Product number
B4305
Product name
4-[(tert-Butoxycarbonylamino)methyl]benzoic Acid
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$39
Updated
2025/07/31
TCI Chemical
Product number
B4305
Product name
4-[(tert-Butoxycarbonylamino)methyl]benzoic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$134
Updated
2025/07/31
TRC
Product number
B619265
Product name
4-(Boc-aminomethyl)benzoic acid
Packaging
5G
Price
$195
Updated
2021/12/16
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4-[(tert-Butoxycarbonylamino)methyl]benzoic acid Chemical Properties,Usage,Production

Chemical Properties

white solid

Uses

4-(Boc-aminomethyl)benzoic Acid is the Boc protected form of 4-(Aminomethyl)benzoic Acid (A615230) and is used as a reagent in the synthesis of indoleamide derivatives as EP2 antagonists with high selectivity. 4-(Boc-aminomethyl)benzoic Acid is also used as a reagent in the synthesis of aminopyridine-derived amides as nicotinamide phosphoribosyltransferase inhibitors.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

56-91-7

24424-99-5

33233-67-9

Phase 1 - Boc Protection: 4-(Aminomethyl)benzoic acid (10.00 g, 65.36 mmol) was stirred with di-tert-butyl dicarbonate (28.0 g, 130.72 mmol) in a solvent mixture of deionized water (100 mL) and tetrahydrofuran (100 mL) at room temperature. The reaction system was adjusted to pH ≈ 6 by slow addition of saturated aqueous sodium bicarbonate solution and the reaction was continuously stirred for 16 hours. Upon completion of the reaction, the reaction solution was carefully acidified to pH ≈ 3 with 1 M hydrochloric acid solution, at which time a white solid precipitated. The solid product was collected by filtration and washed with deionized water and dried to afford 4-[(tert-butoxycarbonylamino)methyl]benzoic acid as a white solid (16.1 g, 97% yield). Mass spectrometry analysis showed m/z = 274 [M + Na]+.

References

[1] Patent: WO2008/53131, 2008, A1. Location in patent: Page/Page column 58; 59-60
[2] Patent: WO2008/40934, 2008, A1. Location in patent: Page/Page column 57-58
[3] Patent: WO2010/20556, 2010, A1. Location in patent: Page/Page column 206
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 965 - 984
[5] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 4, p. 501 - 508

4-[(tert-Butoxycarbonylamino)methyl]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid 33233-67-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
4-[(tert-Butoxycarbonylamino)methyl]benzoic acid 33233-67-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2020-01-02

33233-67-9, 4-[(tert-Butoxycarbonylamino)methyl]benzoic acidRelated Search:

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  • N-T-BUTOXYCARBONYL-4-AMINOMETHYLBENZOIC ACID
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  • BOC-PAMB-OH
  • BOC-P-AMINOMETHYLBENZOIC ACID
  • BOC-HN-CH2-PH(4)-COOH
  • BOC-(4-AMINOMETHYL)-BENZOIC ACID
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  • BOC-AMB-OH
  • AKOS BBS-00000218
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  • 4-{[(tert-Butoxycarbonyl)amino]methyl}benzoic acid, 4-Carboxybenzylamine, N-BOC protected
  • 4-(Boc-aMinoMethyl)benzoic acid >=98.0% (T)
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  • Boc-(4-aminomethyl) benzoic acid99%
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  • 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid USP/EP/BP
  • 4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]benzoic acid
  • 4-[[N-(tert-butyloxycarbonyl)amino]methyl]benzoic acid
  • 4-{[(TERT-BUTOXYCARBONYL)AMINO]METHYL}BENZOATE
  • 4-(Aminomethyl)benzoic acid, N-BOC protected
  • 33233-67-9
  • Aromatic Amino Acids
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Aromatic Amino Acids
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • pharmacetical
  • Amino Acids