ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

ChemicalBook > CAS DataBase List > ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

Product Name: ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
CAS No.: 161798-03-4
Chemical Name: ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
Synonyms: 2-(3-forMyl;Febuxostat-24;-4-isobutoxyphenyL;Febuxostat Impurity G;Febuxostat Impurity 2;Febuxostat Impurities2;Febuxostat Impurity Z18;Febuxostat Impurity Z2-2;Ethyl 2-(3-formyl-4-isobutoxyphenyl);Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiaz
CBNumber: CB11474517
Molecular Formula: C18H21NO4S
Formula Weight: 347.43
MOL File: 161798-03-4.mol

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ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Property

Melting point:: 158-160°C
Boiling point:: 495.9±55.0 °C(Predicted)
Density: 1.183
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 1.39±0.10(Predicted)
color: Pale Yellow
InChI: InChI=1S/C18H21NO4S/c1-5-22-18(21)16-12(4)19-17(24-16)13-6-7-15(14(8-13)9-20)23-10-11(2)3/h6-9,11H,5,10H2,1-4H3
InChIKey: AIQMFFCWDAIGNV-UHFFFAOYSA-N
SMILES: S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C=O)=C1
CAS DataBase Reference: 161798-03-4(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: E702955
Product name: Ethyl2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Packaging: 2.5g
Price: $105
Updated: 2021/12/16

TRC

Product number: E702955
Product name: Ethyl2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Packaging: 10g
Price: $340
Updated: 2021/12/16

Ark Pharm

Product number: P000219191
Product name: Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Purity: 98%
Packaging: 10g
Price: $341
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35350
Product name: Ethyl2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Purity: 95+%
Packaging: 5G
Price: $600
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0068817
Product name: ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

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ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.

Synthesis

Preparation of Compound of formula III)[0094] A compound of formula II (10.0 gr, 34.33 mmol) was reacted with iso- butyl bromide (18.9 gr, 137.3 mmol) in the presence of potassium carbonate (19.0 gr, 137.3 mmol) and potassium iodide (2.3 gr, 13.7 mmol) in 60 ml dimethylformamide. The reaction was performed at about 70°C during 4 hours. The reaction mixture was extracted at 70°C using 300 ml ethyl acetate and 600 ml water. The separated aqueous phase was washed twice with 100 ml ethyl acetate. The combined organic phase was washed twice with 100 ml water and then concentrated to dryness. The resulting solid residue was re- crystallized from 70 ml ethyl acetate, filtered and dried under reduced pressure at about 40°C to provide a compound of formula III (8.9 gr, yield - 83percent). The Compound of formula III purity is 99.1percent (by HPLC).

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Febuxostat Impurity 161798-03-4
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-09-09

HEBEI BRANT PHARMACEUTICAL CO.,LTD

Product: 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylat 161798-03-4
Price: US $0.00-0.00/kg
Min. Order: 100kg
Purity: ≥98.5%
Supply Ability: 20 tons
Release date: 2024-07-30

Hebei Dangtong Import and export Co LTD

Product: ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 161798-03-4
Price: US $100.00-60.00/kilograms
Min. Order: 100kilograms
Purity: 99%
Supply Ability: 100tons
Release date: 2023-02-24

161798-03-4, ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATERelated Search:

Febuxostat Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 6 2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 8 4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide 4-HYDROXYTHIOBENZAMIDE ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 3-Cyano-4-isobutoxybenzoic acid FeBuxostat Impurity 33 Febuxostat impurity 37 Febuxostat-d9

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-

Ethyl-2-(3-Formyl-4-isobutoxy phenyl)-4-methyl-1,3-thiazole-5-carboxylate

Febuxostat-24

2-(3-forMyl

5-Thiazolecarboxylicacid, 2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester

ethyl-2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylate

Febuxostat Impurity 2

Febuxostat Impurity G

2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(3-formyl-4-isobutoxyphenyl)

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

2-(3-Formyl-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester

5-carboxylato-1-ethyl-2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-1H-1$l^{4},3-thiazol-1-yl

Febuxostat Impurity Z18

2-(3-forMyl-4-isobutoxyphenyI)-4-MethyIthiazole-5-carboxylic acid ethyl ester

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiaz

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylicacid ethyl ester

-4-isobutoxyphenyL

Febuxostat intermediates，Ethyl 2-(3-Formyl-4-isobutoxyphenyl)- 4-Methylthiazole-5-Carboxylate

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-

Ethyl 2-(3-Formyl-4-isobutoxyphenyl)-4-Methylthiazole-5-Carb...

Febuxostat Impurities2

2 - (3-aldehyde-4-isobutyloxyphenyl) - 4-methylthiazole-5-carboxylic acid ethyl ester

Ethyl 2-(3- aldehyde -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate

5-Thiazolecarboxylic acid, 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester (9CI, ACI)

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylic acid ethyl ester (9CI ACI)

Febuxostat Impurity Z2-2

Febuxostat Impurity 2 ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate (F4)

2-(3-formyl-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylat

161798-03-4

84006-10-6

1161798-03-4

Febuxostat intermediate

161798-03-4