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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Product Name
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
CAS No.
877397-65-4
Chemical Name
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Synonyms
(S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(S)-1-(2,6-Dichloro-3-fluorophenyl)ethano;(S)-1-(2,6-DichL;JACS-877397-65-4;Crizotinib Interm 7654;-1-(2,6-Dichloro-3-fluorophenyl);(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol;(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
CBNumber
CB11503932
Molecular Formula
C8H7Cl2FO
Formula Weight
209.04
MOL File
877397-65-4.mol
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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Property

Boiling point:
261.3±35.0 °C(Predicted)
Density 
1.406±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
13.30±0.20(Predicted)
form 
Solid
color 
White
InChI
InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3
InChIKey
JAOYKRSASYNDGH-UFLUHPNLNA-N
SMILES
[C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r|
CAS DataBase Reference
877397-65-4
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Safety

HazardClass 
IRRITANT
HS Code 
2906290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H65374
Product name
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
Packaging
1g
Price
$61.2
Updated
2023/06/20
Alfa Aesar
Product number
H65374
Product name
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
Packaging
5g
Price
$273
Updated
2023/06/20
Alfa Aesar
Product number
H65374
Product name
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, 95%
Packaging
250mg
Price
$17.4
Updated
2021/12/16
TRC
Product number
D434235
Product name
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Packaging
50g
Price
$1075
Updated
2021/12/16
ChemScene
Product number
CS-M0263
Product name
(S)-1-(2,6-dichloro-3-fluorophenyl)ethanol
Purity
99.98%
Packaging
100g
Price
$517
Updated
2021/12/16
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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemical Properties,Usage,Production

Uses

(S) -1- (2,6-dichloro-3-fluorophenyl) ethanol(C8H7C12FO) is synthesized (R)-3-[l-(2, 6-dichloro-3-fluoro-benzene)- The key intermediate of ethoxy-5- (l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -pyrimidine-2-indane. And (R)-3-[l-(2,6-dichloro-3-fluoro-benzene)-ethoxy-5-(l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -Pyrimidine-2-indane is a small molecule kinase inhibitor for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) positive for anaplastic lymphohematokinase (ALK).

Uses

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

Synthesis

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is synthesised using (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Sodium methoxide (19 mmol; 0.5 M in methanol) was added slowly to compound S-2 (4.64 g, 18.8 mmol) under a nitrogen atmosphere at 0° C. The resulting mixture was stirred at room temperature for 4 hours. The solvent was evaporated and H2O (100 mL) was added. The cooled reaction mixture was neutralized with sodium acetate-acetic acid buffer solution to pH 7. Ethyl acetate (100 mL.x.2) was added to extract the aqueous solution. The combined organic layers were dried over Na2SO4, filtered, and evaporated to obtain S-1 as a white solid (4.36 g, 94.9percent yield); SFC-MS: 97percent ee. 1H NMR (400 MHz, chloroform-D) δ ppm 1.65 (d, J=6.8 Hz, 3 H) 5.58 (q, J=6.9 Hz, 1H) 6.96-7.10 (m, 1H) 7.22-7.36 (m, 1H).

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Suppliers

Canada 1 China 276 India 2 United Kingdom 3 United States 11 Global 293
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View Lastest Price from (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.
Product
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 877397-65-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
＞98% by HPLC
Supply Ability
10kg/month
Release date
2023-01-09
Nanjing Fred Technology Co., Ltd
Product
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 877397-65-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
Hebei Weibang Biotechnology Co., Ltd
Product
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 877397-65-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21

877397-65-4, (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanolRelated Search:

Phenethyl alcohol 2-Methoxyethanol 2,2,2-TRIFLUOROETHANOL-D3 Dichlorofluoroethane Ethanol 2-AMINO-1-PHENYLETHANOL Dichlorodiphenylsilane Ethyl acetate Perfluoroalkyl alcohol Dichloromethylphenylsilane (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Crizotinib (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine 1-(2,6-DICHLOROPHENYL)ETHANOL Dichlorodifluoromethane (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL

  • BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-, (aS)-
  • (1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol
  • (S)-1-(2,6-dichloro-4-fluorophenyl)ethanol
  • (1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
  • (aS)-2,6-Dichloro-3-fluoro-a-methyl-benzenemethanol
  • -1-(2,6-Dichloro-3-fluorophenyl)
  • (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
  • (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol
  • (S)-1-(2,6-Dichloro-3-fluorophenyl)ethano
  • JACS-877397-65-4
  • (S)-1-(2,6-DichL
  • Benzenemethanol, 2,6-dichloro-3-fluoro-α-methyl-, (αS)-
  • (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol ISO 9001：2015 REACH
  • Crizotinib Interm 7654
  • (αS)-2,6-Dichloro-3-fluoro-α-methylbenzenemethanol
  • (S)-l-(2,6-Dichl〇T〇-3 -fluorophenyl)ethanolethanol
  • 877397-65-4
  • 877399-65-4
  • Aromatic Ring
  • Chiral Compounds