N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- Product Name
- N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- CAS No.
- 792173-99-0
- Chemical Name
- N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- Synonyms
- CS-1891;SB334867/SB-334867;SB334867A free base;SB-334867,CID 6604926;SB-334867 (free base);SB-334867 >=98% (HPLC);N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- CBNumber
- CB11519689
- Molecular Formula
- C17H13N5O2
- Formula Weight
- 319.32
- MOL File
- 792173-99-0.mol
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Property
- Boiling point:
- 450.5±30.0 °C(Predicted)
- Density
- 1.472
- storage temp.
- room temp
- solubility
- insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO
- pka
- 10.21±0.43(Predicted)
- form
- powder
- color
- white to beige
- CAS DataBase Reference
- 792173-99-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1530
- Product name
- SB-334867
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $131
- Updated
- 2023/06/20
- Product number
- SML1530
- Product name
- SB-334867
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $530
- Updated
- 2023/06/20
- Product number
- 19145
- Product name
- SB-334867
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 19145
- Product name
- SB-334867
- Packaging
- 5mg
- Price
- $75
- Updated
- 2024/03/01
- Product number
- 19145
- Product name
- SB-334867
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties,Usage,Production
Uses
SB 334867 is an orexin 1 receptor antagonist.
Definition
ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.
Biological Activity
sb-334867 free base is a selective antagonist of orexin-1 receptor [1].orexin-a and orexin-b are two peptides isolated from rat hypothalamus. they are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.sb-334867 free base could inhibit the orexin-a and orexin-b induced calcium responses in cho-ox1 cells with pkb values of 7.27 and 7.23, respectively. sb-334867 was more selective for ox1 receptor over ox2 receptor. it caused 32.7% and 22% inhibition of orexin-a and orexin-b induced calcium responses in cho-ox2 cells, respectively. moreover, sb-334867 was found to reduce both orexin-a-induced and fasting-induced food intake. the acute anorectic effect of it was associated with significant reductions in all active behaviours [1, 2].
Biochem/physiol Actions
Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867.
storage
Room temperature (desiccate)
References
[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.