Fursultiamine

ChemicalBook > CAS DataBase List > Fursultiamine

Product Name: Fursultiamine
CAS No.: 804-30-8
Chemical Name: Fursultiamine
Synonyms: ttfd;judolor;linamin;Retar B1;adventan;diteftin;Alinaxin;alinaminf;Aliaron F;fursultiamin
CBNumber: CB1161096
Molecular Formula: C17H26N4O3S2
Formula Weight: 398.54
MOL File: 804-30-8.mol

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Fursultiamine Property

Melting point:: 130-136°C (decompos.)
Boiling point:: 652.3±55.0 °C(Predicted)
Density: 1.29
refractive index: 1.6270 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
form: Solid
pka: 14.42±0.10(Predicted)
color: White to Off-White
CAS DataBase Reference: 804-30-8(CAS DataBase Reference)

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Safety

Toxicity: LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F865235
Product name: Fursultiamine
Packaging: 25mg
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: M514
Product name: Fursultiamine
Packaging: 25mg
Price: $98
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002785
Product name: FURSULTIAMINE
Purity: 95.00%
Packaging: 1G
Price: $682.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002785
Product name: FURSULTIAMINE
Purity: 95.00%
Packaging: 5G
Price: $1297.64
Updated: 2021/12/16

AHH

Product number: API-1717
Product name: Fursultiamine
Purity: 98%
Packaging: 5g
Price: $800
Updated: 2021/12/16

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Fursultiamine Chemical Properties,Usage,Production

Description

Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.

Chemical Properties

white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.

Originator

Alinamin F,Takeda,Japan,1961

Uses

Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.

Application

Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.

Preparation

Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.

Definition

ChEBI: Fursultiamine is a member of pyrimidines.

Manufacturing Process

To a solution of 20 parts of thiamine hydrochloride in 30 parts of water is added an aqueous solution of sodium hydroxide (7.2 parts of NaOH in 30 parts of water), and the mixture is cooled with water. The mixture is allowed to stand for 30 minutes, 60 parts of chloroform is added, followed by a solution of 30 parts of crude sodium tetrahydrofurfurylthiosulfate in 30 parts of water, and the whole is stirred for 30 minutes. The chloroform layer is separated and the aqueous layer is extracted twice with 20 parts of chloroform. All the chloroform solutions are combined and shaken with 50 parts of 5% hydrochloric acid. The acid solution is decolorized and neutralized with alkali carbonate, whereupon thiamine tetrahydrofurfuryl disulfide separates out in the resinous state but soon solidifies [MP 129°C (decamp.)] . The yield is 16 parts. Recrystallization from ethyl acetate gives colorless prisms melting at 132°C (decomp.).

Therapeutic Function

Enzyme cofactor vitamin

Fursultiamine Preparation Products And Raw materials

Raw materials

2-Acetylbutyrolactone Acrylonitrile Dimethyl sulfate

Preparation Products

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View Lastest Price from Fursultiamine manufacturers

Henan Tengmao Chemical Technology Co. LTD

Product: Fursultiamine 804-30-8
Price: US $110.00-90.00/kilogram
Min. Order: 1kilogram
Purity: 99%
Supply Ability: 10 tons/per week
Release date: 2024-03-26

Hebei Yanxi Chemical Co., Ltd.

Product: Fursultiamine 804-30-8
Price: US $20.00-5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-09

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fursultiamine 804-30-8
Price: US $0.00/Kg/Drum
Min. Order: 25KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-11-11

804-30-8, FursultiamineRelated Search:

Methylene dithiocyanate Methylparaben Acetonitrile Paraquat dichloride DL-Dithiothreitol Methanol Methyl acrylate 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Dimethyl disulfide Furan CHLOROPHOSPHONAZO III Kresoxim-methyl Selenium sulfide Basic Violet 1 Methyl Fursultiamine HCL JP Thiamine chloride Thiamine disulfide

((tetrahydrofurfuryl)dithio)-1-butenyl)-

adventan

alinaminf

diteftin

fursultiamin

n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamide

Fursutiamine

Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]- (6CI, 8CI)

Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]-

N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]formamide

Retar B1

Tetrahydrofurfuryl thiamine disulfide

Thiamin tetrahydrofurfuryl disulfide

N-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide

Fursultiamine (base and/or unspecified salts)

N-(-4-amino-2-methyl-5-pyrimidinylmethyl)-N-(-4-hydroxyl-1-methyl-2-tetrahyclrofurfury(dithio-1-bute

Fursultiamine###Fursultiamine Hcl

FURSULTIAMINE

Fursultiamine Base

Fursultiaminlim

N-(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]forma

FURSULTIAMINE HYDROCHLORIDE

Aliaron F

Alinaxin

N-[(2-Methyl-4-amino-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydrofuran-2-yl)methyl]dithio]-1-butenyl]formamide

judolor

linamin

retar-b(sub1)

thiaminetetrahydrofurfuryldisulfide

ttfd

Fursultiamine Hydrochloride RS

Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]-

THIAMINE TETRAHYDROFURFURYL DISULFIDE (TTFD)

Fursultiamine USP/EP/BP

Fursultiamine HCL JP USP/EP/BP

Derivative Fursultiamine

N-((4-Amino-2-methylpyrimidin-5-yl)methyl)-N-(5-hydroxy-3-(((tetrahydrofuran-2-yl)methyl)disulfanyl)pent-2-en-2-yl)formamide

Furan thiamine

804-30-8

C17H26N4O3S2

Vitamins and derivatives