ChemicalBook > CAS DataBase List > Ethyl nitroacetate

Ethyl nitroacetate

Product Name
Ethyl nitroacetate
CAS No.
626-35-7
Chemical Name
Ethyl nitroacetate
Synonyms
NSC 42302;JACS-626-35-7;2-nitrobutanoate;Ethlnitroacetate;Ethyl nitrocetate;ETHYL NITROACETATE;NITRO ETHYL ACETATE;EthylNitroacetate>Ethylnitroacetate,97%;Ethyl nitroacetate,98%
CBNumber
CB1175310
Molecular Formula
C4H7NO4
Formula Weight
133.1
MOL File
626-35-7.mol
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Ethyl nitroacetate Property

Boiling point:
105-107 °C/25 mmHg (lit.)
Density 
1.199 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.424(lit.)
Flash point:
198 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
pK1:5.85 (25°C)
form 
Liquid
color 
Clear colorless to slightly yellow
Water Solubility 
Slightly soluble in water. Soluble in chloroform and ethyl acetate.
BRN 
1210027
InChIKey
FTKASJMIPSSXBP-UHFFFAOYSA-N
CAS DataBase Reference
626-35-7(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, nitro-, ethyl ester(626-35-7)
EPA Substance Registry System
Acetic acid, nitro-, ethyl ester (626-35-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
38
Safety Statements 
23-24/25-37
WGK Germany 
2
RTECS 
AJ1074000
Hazard Note 
Irritant
TSCA 
T
HazardClass 
IRRITANT, KEEP COLD
HS Code 
29159080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
192333
Product name
Ethyl nitroacetate
Purity
97%
Packaging
5g
Price
$44.4
Updated
2025/07/31
Sigma-Aldrich
Product number
192333
Product name
Ethyl nitroacetate
Purity
97%
Packaging
25g
Price
$119.7
Updated
2025/07/31
TCI Chemical
Product number
N0657
Product name
Ethyl Nitroacetate
Purity
>95.0%(GC)
Packaging
5g
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
N0657
Product name
Ethyl Nitroacetate
Purity
>95.0%(GC)
Packaging
25g
Price
$164
Updated
2025/07/31
TRC
Product number
E925215
Product name
Ethyl nitroacetate
Packaging
100g
Price
$610
Updated
2021/12/16
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Ethyl nitroacetate Chemical Properties,Usage,Production

Chemical Properties

clear colourless to slightly yellow liquid

Uses

Ethyl nitroacetate has been used in the synthesis of γ-oxoacids via Michael addition reaction with α,β-unsaturated ketones, fuctionalization of C4-position on pyrimidine and C6-position on 2?-deoxyguanosine to produce novel nucleosides, facile synthesis of α,α-diisobutylglycine, synthesis of DL-4,4-difluoroglutamic acid. It is also used as an intermediate in the preparation of unsubstituted amino acids.

Uses

Ethyl Nitroacetate is an ester of nitrocarboxylic acid used as an intermediate in the preparation of unsubstituted amino acids.

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 1208, 1994 DOI: 10.1021/jo00084a047

Purification Methods

Purify the ester by repeated distillation. IR:max 1748 (CO2), 1570 and 1337 (NO2), and 800cm-1 [Haszeldine J Chem Soc 2525 1953]. The hydrazine salt crystallises from 95% EtOH or MeOH as yellow crystals m 104-105o [Ungnade & Kissinger J Org Chem 22 1661 1957, Emmons & Freeman J Am Chem Soc 77 4391 1955]. [Beilstein 2 IV 537.]

Ethyl nitroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

4-HYDROXY-5-NITROPYRIMIDINE 4-BROMO-2-(TRIFLUOROMETHYL)-5-METHOXYPYRIDINE 3-FLUORO-DL-TYROSINE
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View Lastest Price from Ethyl nitroacetate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Ethyl nitroacetate 626-35-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01
Honest Joy Holdings Limited
Product
Ethyl nitroacetate 626-35-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99.1%
Supply Ability
100 tons
Release date
2022-02-21
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl nitroacetate 626-35-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

626-35-7, Ethyl nitroacetateRelated Search:

Ethanol Ethyl acetate Ethylparaben ISOXADIFEN-ETHYL 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Ethyl hydrazinoacetate hydrochloride Ethyl bromoacetate Ethyl phenylacetate Ethyl cyanoacetate Ethyl propiolate Ethyl acrylate ETHYL (METHYLTHIO)ACETATE Trinexapac-ethyl Diethyl nitromalonate Methyl vanillate Cadmium diethyldithiocarbamate Methyl nitroacetate Bromoacetaldehyde diethyl acetal

  • Acetic Acid Nitro Ethyl Ester
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