ChemicalBook > CAS DataBase List > 2-Amino-4-methylbenzonitrile

2-Amino-4-methylbenzonitrile

Product Name
2-Amino-4-methylbenzonitrile
CAS No.
26830-96-6
Chemical Name
2-Amino-4-methylbenzonitrile
Synonyms
6-Cyano-m-toluidine;3-Amino-4-cyanotoluene;2-Cyano-5-methylaniline;2-AMINO-4-METHYLBENZONITRILE;4-Methyl-2-aminobenzonitrile;Benzonitrile, 2-aMino-4-Methyl-;2-Amino-4-methylbenzonitrile >2-Cyano-5-methylaniline, 3-Amino-4-cyanotoluene;3-Amino-4-cyanotoluene 2-Cyano-5-methylaniline 6-Cyano-m-toluidine;2-Cyano-5-methylaniline, 3-Amino-4-cyanotoluene, 6-Cyano-m-toluidine
CBNumber
CB1187357
Molecular Formula
C8H8N2
Formula Weight
132.16
MOL File
26830-96-6.mol
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2-Amino-4-methylbenzonitrile Property

Melting point:
92-95 °C (lit.)
Boiling point:
150-152 °C(Press: 15 Torr)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
form 
Powder
pka
1.94±0.10(Predicted)
color 
Light yellow to Yellow to Orange
CAS DataBase Reference
26830-96-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-36/37
RIDADR 
3439
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
214280
Product name
2-Amino-4-methylbenzonitrile
Purity
97%
Packaging
1g
Price
$33.85
Updated
2025/07/31
Sigma-Aldrich
Product number
214280
Product name
2-Amino-4-methylbenzonitrile
Purity
97%
Packaging
5g
Price
$115
Updated
2025/07/31
TCI Chemical
Product number
A2448
Product name
2-Amino-4-methylbenzonitrile
Purity
>98.0%(GC)
Packaging
1g
Price
$105
Updated
2025/07/31
TCI Chemical
Product number
A2448
Product name
2-Amino-4-methylbenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$332
Updated
2025/07/31
TRC
Product number
A577268
Product name
2-Amino-4-methylbenzonitrile
Packaging
1g
Price
$75
Updated
2021/12/16
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2-Amino-4-methylbenzonitrile Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-4-methylbenzonitrile was used in the synthesis of:

  • 7-methyl-4-(phenylamino)quinazoline-2(1H)-selone
  • racemic aminoquinolines, potential acetylcholinesterase (AChE) inhibitors

Synthesis

26830-95-5

26830-96-6

a) Synthesis of 2-amino-4-methylbenzonitrile 4-Methyl-2-nitrobenzonitrile (4.9 g, 30 mmol) was mixed with 10% palladium-carbon catalyst (500 mg) in 1,4-dioxane (60 mL), and the reaction was stirred overnight under a hydrogen atmosphere (balloon pressurized). Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was further purified by fast column chromatography (eluent: dichloromethane) to afford 2-amino-4-methylbenzonitrile as a light yellow solid (3.3 g, 83% yield). 1H-NMR (300 MHz, CDCl3) δ 7.26 (d, J = 8.3 Hz, 1H), 6.56 (s, 1H), 6.55 (s, 1H), 4.32 (br s, 2H), 2.29 (s, 3H).

References

[1] Chemical Communications, 2011, vol. 47, # 31, p. 8808 - 8810
[2] Journal of the Chemical Society, Perkin Transactions 2, 2001, # 2, p. 214 - 228
[3] Patent: US5891909, 1999, A
[4] Patent: EP906091, 2006, B1. Location in patent: Page/Page column 46
[5] Journal fuer Praktische Chemie (Leipzig), 1889, vol. <2> 40, p. 12

2-Amino-4-methylbenzonitrile Preparation Products And Raw materials

Raw materials

Copper(I) Cyanide 4-Chloro-3-nitrotoluene Ethanol N,N-Dimethylformamide Acetic acid Iron

Preparation Products

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View Lastest Price from 2-Amino-4-methylbenzonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Amino-4-methylbenzonitrile 26830-96-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Amino-4-methylbenzonitrile 26830-96-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
2-Amino-4-methylbenzonitrile 26830-96-6
Price
US $3.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-09

26830-96-6, 2-Amino-4-methylbenzonitrileRelated Search:

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  • C8 to C9
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  • Organic Building Blocks
  • Aromatic Nitriles
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