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Glycine hydrochloride

Product Name
Glycine hydrochloride
CAS No.
6000-43-7
Chemical Name
Glycine hydrochloride
Synonyms
GLYCINE HCL;GLYCINE-HCL BUFFER;Gly.HCL;h-gly-oh.hcl;ycine hydrochL;GLYCINE HYDROCHLORIDE;Glycocol hydrochloride;GLYCOCOLL HYDROCHLORIDE;GlycineHydrochloride>Glycinehydrochloride,98%
CBNumber
CB1224948
Molecular Formula
C2H6ClNO2
Formula Weight
111.53
MOL File
6000-43-7.mol
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Glycine hydrochloride Property

Melting point:
176-180 °C(lit.)
Density 
1.457[at 20℃]
vapor pressure 
0.003Pa at 20℃
storage temp. 
2-8°C
form 
Crystalline Powder
color 
White to almost white
Water Solubility 
SLIGHTLY SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,4491
BRN 
3909617
LogP
-3.25 at 20℃
CAS DataBase Reference
6000-43-7(CAS DataBase Reference)
EPA Substance Registry System
Glycine, hydrochloride (6000-43-7)
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Safety

Risk Statements 
22
Safety Statements 
24/25-44
RIDADR 
UN 1789 8/PG 3
WGK Germany 
2
RTECS 
MC0560000
10
TSCA 
Yes
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G2879
Product name
Glycine hydrochloride
Purity
≥99% (HPLC)
Packaging
1kg
Price
$374
Updated
2024/03/01
TCI Chemical
Product number
G0103
Product name
Glycine Hydrochloride
Purity
>99.0%(T)
Packaging
25g
Price
$109
Updated
2024/03/01
Alfa Aesar
Product number
A12162
Product name
Glycine hydrochloride, 98%
Packaging
100g
Price
$56.7
Updated
2024/03/01
Alfa Aesar
Product number
A12162
Product name
Glycine hydrochloride, 98%
Packaging
500g
Price
$182
Updated
2024/03/01
Sigma-Aldrich
Product number
PHG0016
Product name
Glycine hydrochloride
Purity
PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production., suitable for cell culture
Packaging
100g
Price
$235
Updated
2024/03/01
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Glycine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white crystals or crystalline powder

Uses

Glycine hydrochloride is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.Glycine Hydrochloride is commonly used in buffer solutions, in electrophoresis, and preparative chromatography.

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.
Glycine hydrochloride has been used:
in the preparation of glycine-HCl buffer
to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
to regenerate the sensor to elute the bound C-reactive protein (CRP)

Definition

Glycine hydrochloride is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

Preparation

Glycine hydrochloride can be prepared by the action of hydrochloric acid on hippuric acid,aminoacetonitrile,methyleneaminoacetonitrile, and on ethyl phthaliminoacetate. Aniline has been recommended for its conversion into free glycine. Glycine can also be prepared by the interaction of chloroacetic acid and ammonia; by the hydrolysis of methyleneaminoacetonitrile by successive treatments with barium hydroxide and sulfuric acid; and by the hydrolysis of aminoacetonitrile by means of barium hydroxide. A thorough study has been reported for its preparation in improved yields by the sulfuric acid hydrolysis of aminoacetonitrile, and in satisfactory yields from chloroacetic acid and ammonia. Other methods of preparation include the reduction of cyanoformic esters, a modified Curtius degradation of ethyl cyanoacetate, and the hydrolysis of the neck ligaments of cattle.
synthesis of Glycine hydrochloride

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.
Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia and reperfusion.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Purification Methods

Crystallise the salt from absolute EtOH or 80% EtOH. Monoglycine hydrochloride has m 176-177o, and diglycine monohydrochloride has m 187o. [Frost J Am Chem Soc 64 1286 1942, Beilstein 4 III 1111, 4 IV 2353.]

Glycine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Glycine hydrochloride Suppliers

Wuhan lanabai Pharmaceutical Chemical Co., Ltd
Tel
15307151931
Fax
QQ-2355680
Email
2355680@qq.com
Country
China
ProdList
5547
Advantage
58
Wuhan Xinyangruihe Chemical Technology Co., Ltd.
Tel
13720274133
Fax
027-83850377
Email
2395204132@qq.com
Country
China
ProdList
3569
Advantage
58
NANJING YIHUA BIOTECHNOLOGY Co., Ltd
Tel
15171470753
Email
3105244229@qq.com
Country
China
ProdList
284
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
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View Lastest Price from Glycine hydrochloride manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Glycine hydrochloride 6000-43-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-18
Hebei Kingfiner Technology Development Co.Ltd
Product
Glycine hydrochloride 6000-43-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
50000kg
Release date
2024-06-03
Henan Aochuang Chemical Co.,Ltd.
Product
Glycine hydrochloride 6000-43-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10

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