ChemicalBook > CAS DataBase List > (R)-1-Boc-3-hydroxypyrrolidine

(R)-1-Boc-3-hydroxypyrrolidine

Product Name
(R)-1-Boc-3-hydroxypyrrolidine
CAS No.
109431-87-0
Chemical Name
(R)-1-Boc-3-hydroxypyrrolidine
Synonyms
tert-butyl (R)-3-hydroxypyrrolidine-1-carboxylate;(R)-1-N-Boc-3-pyrrolidinol;(R)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE;tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate;tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate;CAS:109431-87-0;Ivankasse impurity 18;(R)-1-BOC-3- Pyrolidinol;N-Boc-(R)-3-pyrrolidinol;(R)-1-BOC-3-PYRROLIDINOL
CBNumber
CB1232376
Molecular Formula
C9H17NO3
Formula Weight
187.24
MOL File
109431-87-0.mol
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(R)-1-Boc-3-hydroxypyrrolidine Property

Melting point:
62-65 °C(lit.)
alpha 
-7 º (c=1, MeOH)
Boiling point:
273.3±33.0 °C(Predicted)
Density 
1.142±0.06 g/cm3(Predicted)
refractive index 
-27 ° (C=1, MeOH)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
14.74±0.20(Predicted)
form 
Powder
color 
White to off-white
optical activity
[α]20/D 26±1, c = 1 in methanol
InChI
InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3/t7-/m1/s1
InChIKey
APCBTRDHCDOPNY-SSDOTTSWSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC[C@@H](O)C1
CAS DataBase Reference
109431-87-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-53-50-50/53
Safety Statements 
26-36
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
532169
Product name
(R)-(?)-N-Boc-3-pyrrolidinol
Purity
98%
Packaging
1g
Price
$21.36
Updated
2025/07/31
Sigma-Aldrich
Product number
532169
Product name
(R)-(?)-N-Boc-3-pyrrolidinol
Purity
98%
Packaging
5g
Price
$44.87
Updated
2025/07/31
TCI Chemical
Product number
B3054
Product name
(R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity
>98.0%(GC)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
B3054
Product name
(R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity
>98.0%(GC)
Packaging
5g
Price
$108
Updated
2025/07/31
TRC
Product number
B665905
Product name
(R)-1-N-Boc-3-pyrrolidinol
Packaging
10g
Price
$155
Updated
2021/12/16
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(R)-1-Boc-3-hydroxypyrrolidine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Used in synthesis of ligands for the nicotinic acetylcholine receptor.

Synthesis

24424-99-5

40499-83-0

83220-73-9

1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine (compound 16) was synthesized by a four-step reaction using di-tert-butyl dicarbonate and 3-hydroxy-pyrrolidine. First, (R)-3-pyrrolidinol (539 mg, 6.19 mmol) was converted to compound 16b to afford a colorless oily product (1.3 g, 100% yield). The spectral data of the product were consistent with the expected structure and in accordance with literature reports (see Kucznierz, R. et al., J. Med. Chem. 1998, 41, 4983-4994). Subsequently, compound 16b was further converted to compound 16c, again as a colorless oil. Next, compound 16c was converted by a two-step reaction to compound 16e, still a colorless oily substance. Finally, compound 16e was converted to the target product compound 16 to give a yellow oily substance.

References

[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86

(R)-1-Boc-3-hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-Boc-3-hydroxypyrrolidine Suppliers

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View Lastest Price from (R)-1-Boc-3-hydroxypyrrolidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
(R)-1-Boc-3-hydroxypyrrolidine 109431-87-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-07-04
Henan Aochuang Chemical Co.,Ltd.
Product
(R)-1-Boc-3-hydroxypyrrolidine 109431-87-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Shaanxi Dideu Medichem Co. Ltd
Product
(R)-(-)-N-Boc-3-pyrrolidinol 109431-87-0
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-27

109431-87-0, (R)-1-Boc-3-hydroxypyrrolidineRelated Search:

N-Vinyl-2-pyrrolidone Pyrrolidine tert-Butanol 3-Pyrrolidinol tert-Butyl peroxyacetate N-Methyl-2-pyrrolidone tert-Butyl acetate Polyvinylpyrrolidone Povidone iodine (R)-1-BOC-2-METHYL-PYRROLIDINE (R)-N-Boc-3-aminomethylpiperidine N-Boc-L-alaninol 1-(tert-Butoxycarbonyl)-3-pyrrolidinol METHYL-2-PYRROLIDONE (R)-3-Hydroxypyrrolidine DL-3-PYRROLIDINOL (R)-1-Boc-3-hydroxypyrrolidine (2S,4R)-1-(tert-butoxycarbonyl)-4-[2-chloro-5-(trifluoromethyl)phenoxy]pyrrolidine-2-carboxylic acid

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  • tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
  • (R)-(-)-N-Boc-3-pyrrolidinol, ee: 98%
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  • (R)-1-N-Boc-hydroxypyrrolidine
  • (R)-(-)-N-Boc-3-pyrrolidinol, 98%, ee: 98%
  • N-(tert-Butoxycarbonyl)-(R)-3-hydroxypyrrolidine
  • (R)-1-Boc-3-hydroxypyrrolidine
  • (R)-1-(Tert-Butoxycarbonyl)
  • (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
  • N-Boc-(R)-(-)-3-hydroxypyrrolidine
  • N-TERT-BUTOXYCARBONYL-(R)-(+)-3-PYRROLID
  • (R)-N-BOC-3-HYDROPYRROLIDINE
  • (3R)-(-)-N-BOC-3-HYDROXYPYROLIDINE
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  • tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate
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  • N-TERT-BUTOXYCARBONYL-(R)-(-)-3-PYRROLIDINOL
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  • (R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol &gt
  • C9H17NO3 (R)-(-)-N-Boc-3-pyrrolidinol 109431-87-0
  • China biggest manufacturer (R)-1-Boc-3-hydroxypyrrolidine 109431-87-0
  • Ivankasse impurity 18
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  • R-N-tert.butylcarbonyl-3-pyrrolidinol
  • Bexagliflozin Impurity 19