2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione

Product Name: 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
CAS No.: 446292-07-5
Chemical Name: 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
Synonyms: C21H2IN3Os .;2-Amino-12-picoline;Rivaroxaban Impurity 50;Rivaroxaban interMediate B;Rivaroxaban Intermediates I;Intermediate of Rivaroxaban 4;-2-(2-Hydroxy-3-((4-(3-oxomorpholino);Rivaroxaban Phthalimido Descarbonyl Impurity;2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}pr...;4-[((2R)-Hydroxy-3-phthaliMido)propylaMine]phenyl-3-Morpholinone
CBNumber: CB12468597
Molecular Formula: C21H21N3O5
Formula Weight: 395.41
MOL File: 446292-07-5.mol

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2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Property

Melting point:: 208-211°C
Boiling point:: 734.9±60.0 °C(Predicted)
Density: 1.421
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 13.91±0.20(Predicted)
form: Solid
color: White to Off-White
Water Solubility: 37mg/L at 20℃
LogP: 0.6 at 25℃
CAS DataBase Reference: 446292-07-5

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: H948920
Product name: 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
Packaging: 25mg
Price: $385
Updated: 2021/12/16

TRC

Product number: H948920
Product name: 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
Packaging: 50mg
Price: $725
Updated: 2021/12/16

AK Scientific

Product number: Z3537
Product name: 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-mopholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2h)-dione
Packaging: 100mg
Price: $82
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0032813
Product name: (R)-2-(2-HYDROXY-3-((4-(3-OXOMORPHOLINO)PHENYL)AMINO)PROPYL)ISOINDOLINE-1,3-DIONE
Purity: 95.00%
Packaging: 1G
Price: $402.15
Updated: 2021/12/16

AK Scientific

Product number: Z3537
Product name: 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-mopholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2h)-dione
Packaging: 1g
Price: $139
Updated: 2021/12/16

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2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone is a Rivaroxaban (R538000(P)) intermediate. Rivaroxaban is a novel antithrombotic agent. It is also a highly potent and selective, direct FXa inhibitor.

Uses

Rivaroxaban intermediate.

Flammability and Explosibility

Non flammable

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Suppliers

Canada 1 China 232 India 13 United Kingdom 2 United States 9 Global 257

AbaChemScene

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Cato Research Chemicals Inc.

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View Lastest Price from 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione manufacturers

Anhui Dexinjia Biopharm Co., Ltd

Product: 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione 446292-07-5
Price: US $100.00-2500.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2MT per month
Release date: 2023-12-26

Changzhou Rokechem Technology Co., Ltd.

Product: 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-1H-ISOINDOLE- 1,3(2H)-DIONE 446292-07-5
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99%
Supply Ability: 1-10000kgs
Release date: 2023-05-25

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: 1H-isoindole-1,3(2H) -Dione, 2-[(2R) -2-Hydroxy-3 -[[4-(3-OXO-4-morpholinyl)PHENYL]AMINO]PROPYL]- 446292-07-5
Price: US $30.00-28.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2022-10-06

446292-07-5, 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dioneRelated Search:

1,2-BenzenedicarboxaMide, N1,N2-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-QuinazolineMethanol, 4-Methyl- Rivaroxaban Impurity 34 (R)-N-Glycidylphthalimide 4,5-DICHLOROTHIOPHENE-2-CARBOXYLIC ACID 2-Thiophenecarboxylic acid 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Rivaroxaban POLYSTYRENE IODOSOACETATE 1,2-Cyclohexanedione (S)-(+)-Epichlorohydrin 4-(4-NITROPHENYL)MORPHOLIN-3-ONE (S)-(+)-Glycidyl Phthalimide 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Rivaroxaban Impurity 10/4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone

1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-

4-[((2R)-Hydroxy-3-phthaliMido)propylaMine]phenyl-3-Morpholinone

2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione

2-[(2R)-2-hydroxy-3-{[4-(3-oxoMorpholin-4-yl)phenyl]aMino}p ropyl]-1H-isoindole-1,3(2H)-dione

(R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)-amino)propyl)isoindoline-1,3-dione

Rivaroxaban interMediate B

2-[(2R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)anilino]propyl]isoindole-1,3-dione

Rivaroxaban Phthalimido Descarbonyl Impurity

2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-

-2-(2-Hydroxy-3-((4-(3-oxomorpholino)

Rivaroxaban Impurity 50

H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-

R –(2-Hydroxy-3-((4-(3-Oxo morpholino) Phenyl) Amino) Propyl) Isoindoline-1,3-dione

2-Amino-12-picoline

2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}pr...

TIANFUCHEM--446292-07-5---1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-

C21H2IN3Os .

Intermediate of Rivaroxaban 4

Rivaroxaban Intermediates I

(R)-2-{2-Hydroxy-3-[4-(3-oxo-morpholin-4-yl)-phenylamino]-propyl}-isoindole-1,3-dione

446292-07-5

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Intermediate of Rivaroxaban