Elacridar HCl

Product Name: Elacridar HCl
CAS No.: 143851-98-3
Chemical Name: Elacridar HCl
Synonyms: EOS-62093;Elacridar HC1;Elacridar HCl;Elacridar HCl USP/EP/BP;Elacridar (hydrochloride);Elacridar HCl (GF120918A);GF 120918A; GF120918A; GF-120918A;N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihy;N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide,hydrochloride;N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamidehydrochloride
CBNumber: CB12473818
Molecular Formula: C34H33N3O5.ClH
Formula Weight: 600.112
MOL File: 143851-98-3.mol

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Elacridar HCl Property

Melting point:: >198oC (dec.)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated)
form: Solid
color: Orange
Stability:: Hygroscopic
CAS DataBase Reference: 143851-98-3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4646
Product name: Elacridarhydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $238
Updated: 2021/12/16

Usbiological

Product number: 145672
Product name: Elacridar hydrochloride
Packaging: 10mg
Price: $522
Updated: 2021/12/16

ChemScene

Product number: CS-1113
Product name: Elacridarhydrochloride
Purity: 99.73%
Packaging: 100mg
Price: $528
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611516
Product name: Elacridar hydrochloride
Packaging: 250mg
Price: $615.4
Updated: 2021/12/16

Matrix Scientific

Product number: 153515
Product name: N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-3-carboxamide hydrochloride
Purity: 95%
Packaging: 100mg
Price: $648
Updated: 2021/12/16

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Elacridar HCl Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Uses

Antineoplastic (adjunct).

Uses

Elacridar Hydrochloride is a dual P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor.

in vivo

Elacridar hydrochloride (100 mg/kg; i.p. once) shows different distribution in brain and plasma^[1].

1.19Plasma Pharmacokinetic Parameters of Elacridar hydrochloride in mice^[1].

	Mice PO 100 mg/kg	Mice IP 100 mg/kg	Mice IV 2.5 mg/kg
CL/F (ml/min)	2.05	33.2	0.46
Vd/F (liter)	3.5	12.3	0.17
t_1/2 (h)	20	4.3	4.4
AUC_0-inf (μg·min/ml)	1460	90.3	161.4
F	0.22	0.013	1

Animal Model:	FVB wild-type mice^[1]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; 100 mg/kg once
Result:	Showd a higher concertration in brain than plasma except at 4 h after administration.

storage

Store at -20°C

Elacridar HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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Elacridar HCl Suppliers

China 67 India 1 The Netherlands 1 United Kingdom 2 United States 14 Global 85

Shanghai Boyle Chemical Co., Ltd.

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Shanghai Send Pharmaceutical Technology Co., Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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143851-98-3, Elacridar HClRelated Search:

Elacridar Betaine hydrochloride Dimethylamine hydrochloride Trimethylamine hydrochloride Pyridine hydrochloride Methylamine hydrochloride Cysteamine hydrochloride Triethylamine hydrochloride

1-{2-carbaMoyl-5-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}-5-Methoxy-9-oxo-9,10-dihydroacridine-4-carboxylic acid hydrochloride

GW 0918 N-[4-[2-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-Methoxy-9-oxo-4-acridinecarboxaMide, (HCl salt)

Elacridar (hydrochloride)

4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, hydrochloride (1:1)

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide monohydrochloride

N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamidehydrochloride

Elacridar HC1

Elacridar HCl

N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihy

EOS-62093

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride

GF 120918A; GF120918A; GF-120918A

N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide,hydrochloride

Elacridar HCl USP/EP/BP

Elacridar HCl (GF120918A)

143851-98-3

C34H33N3O5HCl

C34H34ClN3O5