TPEN
- Product Name
- TPEN
- CAS No.
- 16858-02-9
- Chemical Name
- TPEN
- Synonyms
- TPEN;TPEDA;CS-960;TPEN, >=98%;TPEN/CH63857;TPEN, 10 mM in DMSO;TPEN ISO 9001:2015 REACH;TPEN, Metal ion chelator;TPEN - CAS 16858-02-9 - Calbiochem;N,N'-Ethylenebis[bis(2-pyridyl)amine]
- CBNumber
- CB1249909
- Molecular Formula
- C26H28N6
- Formula Weight
- 424.54
- MOL File
- 16858-02-9.mol
TPEN Property
- Melting point:
- 110-112 °C
- Boiling point:
- 530.56°C (rough estimate)
- Density
- 1.3893 (rough estimate)
- refractive index
- 1.4570 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (up to 10 mg/ml).
- pka
- 5.19±0.12(Predicted)
- form
- Tan solid
- color
- Off-white or tan
- BRN
- 4211982
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 16858-02-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- P4413
- Product name
- N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine
- Packaging
- 50mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- P4413
- Product name
- N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine
- Packaging
- 100mg
- Price
- $148
- Updated
- 2024/03/01
- Product number
- 616394
- Product name
- TPEN - CAS 16858-02-9 - Calbiochem
- Packaging
- 100mg
- Price
- $192
- Updated
- 2024/03/01
- Product number
- T1487
- Product name
- N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $213
- Updated
- 2024/03/01
- Product number
- T1487
- Product name
- N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $722
- Updated
- 2024/03/01
TPEN Chemical Properties,Usage,Production
Description
TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2
Chemical Properties
Colourless Crystals
Uses
Membrane-permeable zinc chelator; decreased the intracellular level of zinc and induced apoptosis.
Definition
ChEBI: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
reaction suitability
reagent type: chelator
Biochem/physiol Actions
N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling. In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression. It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells.
storage
Store at +4°C
References
1) Chimienti et al. (2001) Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases and cleavage of Sp family transcription factors; Biochem. Pharmacol. 62 51 2) Meplan et al. (2000) Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells; Oncogene 19 5227
TPEN Preparation Products And Raw materials
Raw materials
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View Lastest Price from TPEN manufacturers
- Product
- TPEN 16858-02-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27
- Product
- TPEN 16858-02-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- TPEN 16858-02-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25