5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole

Product Name: 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole
CAS No.: 102625-64-9
Chemical Name: 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole
Synonyms: Pantoprazole-2;PANTOPRAZOLE SULFIDE;pantoprazole sulphide;Pantoprazole Ep Imp B;Pantoprazole Thioether;PantoprazoleSulfide>5-DifluoroMethoxy-2-[(3;Pantoprazole condensate;Pantoprazole Sulfur ether;Pantoprazole EP IMpurity B
CBNumber: CB1253016
Molecular Formula: C16H15F2N3O3S
Formula Weight: 367.37
MOL File: 102625-64-9.mol

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5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Property

Melting point:: 110-118°C
Boiling point:: 526.3±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 8.97±0.10(Predicted)
color: Off-White to Light Brown
BRN: 5358607
InChI: InChI=1S/C16H15F2N3O3S/c1-22-13-5-6-19-12(14(13)23-2)8-25-16-20-10-4-3-9(24-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
InChIKey: UKILEIRWOYBGEJ-UHFFFAOYSA-N
SMILES: C1(SCC2=NC=CC(OC)=C2OC)NC2=CC(OC(F)F)=CC=C2N=1
CAS DataBase Reference: 102625-64-9(CAS DataBase Reference)

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Safety

HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3074
Product name: Pantoprazole Related Compound B
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $336.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1494910
Product name: Pantoprazole Related Compound B
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1300
Updated: 2025/07/31

TCI Chemical

Product number: P2066
Product name: Pantoprazole Sulfide
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: P2066
Product name: Pantoprazole Sulfide
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $81
Updated: 2025/07/31

Cayman Chemical

Product number: 22251
Product name: Pantoprazole Sulfide
Purity: ≥98%
Packaging: 1g
Price: $32
Updated: 2024/03/01

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5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

A metabolite of Pantoprazole, an antiulcerative, gastric pump inhibitor

Uses

Pantoprazole Sulfide (Pantoprazole EP Impurity B) is a metabolite of Pantoprazole (P183000), an antiulcerative, gastric pump inhibitor.

Synthesis

169905-10-6

97963-62-7

102625-64-9

[Example 1] Preparation of 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole: 920 mL of isopropanol, 92.1 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole, and 95.8 g of 2-chloromethyl-3,4-dimethoxypyridine were added to the reactor. Sodium hydroxide solution (prepared by dissolving 20.5 g of sodium hydroxide in 920 mL of pure water) was added slowly and dropwise to the above mixture, followed by stirring the reaction mixture for 2 hours at room temperature. Upon completion of the reaction, 920 mL of pure water was added to the mixture and stirring was continued for 1 hour. The resulting solid product was collected by filtration and dried under vacuum to give 137.4 g of the target compound in 87.8% yield with a melting point of 94 °C.

References

[1] Patent: WO2009/75516, 2009, A2. Location in patent: Page/Page column 4
[2] Organic Process Research and Development, 2013, vol. 17, # 10, p. 1272 - 1276

5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole manufacturers

Qiuxian Baitai New Material Co., LTD

Product: Pantoprazole sulfide 102625-64-9
Price: US $35.00/KG
Min. Order: 500KG
Purity: ≥98%
Supply Ability: 100tons
Release date: 2021-11-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: Pantoprazole Sulfide 102625-64-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Pantoprazole Sulfide 102625-64-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

102625-64-9, 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazoleRelated Search:

4-Methoxybenzyl alcohol 4-Methoxybenzyl cyanide p-Anisaldehyde Tribenuron methyl p-Anisidine 4-Methoxybenzoic acid METSULFURON METHYL 4-Methoxyphenol Anisole PANTOPRAZOLE SULPHONE SODIUM SALT Methyl acetate (Trifluoromethoxy)benzene Kresoxim-methyl Guaiacol Methyl salicylate Dimethoxymethane Thiophanate-methyl 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole

Pantoprazole Related Compound B (25 mg) (5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole)

Pantoprazole Thioether

5-(DifluoroMethoxy)-2-(((3,4-diMethoxypyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole

5-(DIFLUOROMETHOXY)-2-[[3,4-DIMETHOXY-2-PYRIDINYL)-METHYL]-THIO]-1H- BENZIMIDAZOLE (PANTOPRAZOLE SULPHIDE COMPOUND)

Pantoprazole Thioether, 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole

5-(Difluoromethoxy)-2-{[3,4-di

5-Difluoromethoxy-2-{[(3,4-dim

5-(DIFLUOROMETHOXY)-2-{[3,4-DIMETHOXY-2-PYRIDINYL)METHYL]THIO}IH- BENZIMIDAZOLE

5-Difluoromethoxy-2-(((3,4-Dimethoxy-2-pyridinyl)methyl)thio)-1H-Benzimidazole (Pantaprazole intermediate)

5-(Difluoromethoxy)-2-{[(3,4-dimethoxy-2-pyridinyl)-methyl]-thio}-1H-benzim

5-DIFLUOROMETHOXY-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL] THIO-1H-BENZIMIDAZOLE =98%

5-DIFLUORMETHOXY-2[(3,4-DIMETHOXY-2-PRIDIXY)METHYLTHIO]-1H-BENZIMIDAZOLE

5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]thio}-1H-benzimidazole

5-Difluoromethoxy-2-(3,4-dimethoxy-pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole

5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulphanyl}-1H-benzimidazole

Pantoprazole Related CoMpound B

Pantoprazole Impurity 2(Pantoprazole EP Impurity B)

4-diMethoxy-2-pyridinyl)Methyl]thio-1H-benziMidazole

5-DifluoroMethoxy-2-[(3

Pantoprazole Sulphide Compound

Pantoprazole EP IMpurity-B (USP RC B)

5-DIFLUOROMETHOXY-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]THIO-1H-BENZIMIDAZOLE PANTOPRAZOLE SULFIDE

Pantoprazole EP IMpurity B

5-DifluoroMethoxy-2-[(3,4-diMethoxy-2-pyridyl)Methyl]thio-1H-benziMidazole, 95%

Pantoprazole Sulfide (Pantoprazole IMpurity B)

5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridiny)-methyl]thio]-1H-benzimidazole

1H-BenziMidazole,6-(difluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]thio]-

Pantoprazole Sodium Hydrate Impurity

pantoprazole sulphide

Pantoprazole Related CoMpound

PANTOPRAZOLE SULFIDE

Pantoprazole Sodium impurity

5-(Difluoromethoxy)-2- {[( 3,4 Dimethoxypyridin - 2- yl) methyl] thio}-1H-benzimidazolee

5-DIFLUOROMETHOXY-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]THIO-1H-BENZIMIDAZOLE

Pantoprazole Ep Imp B

Pantoprazole-2

Pantoprazole EP Impurity B (Pantoprazole Sulfide)

Pantoprazole sodium impurity B

PantoprazoleSulfide&gt

Pantoprazole Sulfur ether

5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]thio]benzimidazole

5-(Difluoromethoxy)-2- [[(3,4-dimethoxy-2- pyridinyl)-2-methyl]thio]- 1H-benzimidazole

5-(Difluoromethoxy)-2-{[(3,4Dimethoxy pyridin-2- yl)methyl]thio}-1h-Benzimidazole(PantoSulphide)

Pantoprazole EP Impurity B/ Pantoprazole Related Compound B (Pantoprazole Sulfide)

Pantoprazole SulphideQ: What is Pantoprazole Sulphide Q: What is the CAS Number of Pantoprazole Sulphide Q: What is the storage condition of Pantoprazole Sulphide Q: What are the applications of Pantoprazole Sulphide

Pantoprazole Related Compound B (5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H (1494910)

PantoprazoleEPImpurityB-d6

5-Difluoromethoxy-2-H[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H- benzimidazole

Pantoprazole USP Related Compound B

5-(Difluoro methoxy)-2-{[(3,4 dimethoxypyridin-2-yl)methyl]thio}-1H-benzimidazole (Panto Sulfide)

5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl]-1H-benzimidazole

5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2- yl)methyl]thio}-1H-benzimidazole?(SULPHIIDE)

Pantoprazole Sodium EP Impurity B

Pantoprazole Sodium Sesquihydrate Impurity B

5-(Difluromethoxy)-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-Benzimidazole(pantoprazole sulfide)

5-Difluoromethoxy-2 {[(3,4-dimethyl-2-pyridyl) methyl] sulfur}-1H-benzimidazole

Pantoprazole condensate

Pantoprazole Sulfide, ≥ 98.0%