RETRORSINE

Product Name: RETRORSINE
CAS No.: 480-54-6
Chemical Name: RETRORSINE
Synonyms: Retrosine;RETRORSIN;RETRORSINE;Retrorcine;β-Longilobine;RETRORSINE(AS);BETA-LONGILOBINE;cis-retronecicacidesterofretronecine;16-dione,12,18-dihydroxy-senecionan-1;12,18-DIHYDROXYSENECIONAN-11,16-DIONE
CBNumber: CB1256406
Molecular Formula: C18H25NO6
Formula Weight: 351.39
MOL File: 480-54-6.mol

More

Less

RETRORSINE Property

Melting point:: 208-211 °C (lit.)
alpha: D18 -17.6° (c = 1.99 in ethanol)
Boiling point:: 485.2°C (rough estimate)
Density: 1.32±0.1 g/cm3 (20 ºC 760 Torr)
refractive index: 1.5100 (estimate)
storage temp.: 2-8°C
pka: 12.00±0.40(Predicted)
form: Solid
color: White to off-white
Merck: 13,8253
InChIKey: BCJMNZRQJAVDLD-VMOBWIEOSA-N
CAS DataBase Reference: 480-54-6
IARC: 3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System: Retrorsine (480-54-6)

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 22-36/37/39-45
RIDADR: 1544
WGK Germany: 3
RTECS: VH7525000
HazardClass: 6.1(a)
PackingGroup: II
Hazardous Substances Data: 480-54-6(Hazardous Substances Data)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R0382
Product name: Retrorsine
Purity: ≥90% (HPLC)
Packaging: 100mg
Price: $261
Updated: 2024/03/01

Sigma-Aldrich

Product number: R0382
Product name: Retrorsine
Purity: ≥90% (HPLC)
Packaging: 500mg
Price: $898
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89775
Product name: Retrorsine
Purity: phyproof Reference Substance
Packaging: 10mg
Price: $342
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0009902
Product name: RETRORSINE
Purity: 95.00%
Packaging: 10MG
Price: $573.3
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48570
Product name: Retrorsine
Packaging: 10mg
Price: $585
Updated: 2021/12/16

More

Less

RETRORSINE Chemical Properties,Usage,Production

Uses

Retrorsine-D4 is a labelled analogue of Retrorsine (R279000). Retrorsine is a pyrrolizidine alkaloid that blocks the hepatocyte cell cycle, ultimately affecting hepatocyte proliferative capacity.

Definition

ChEBI: Retrorsine is a macrolide.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. hhtation data reported. When heated to decomposition it emits toxic fumes of NOx.

RETRORSINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

RETRORSINE Suppliers

China 76 France 1 Germany 2 India 2 Switzerland 1 United Kingdom 1 United States 11 USA 1 Global 95

ALB Technology Limited

Tel: 702-983-3769
Fax: 702-983-3769
Email: sales@albtechnology.com
Country: United States
ProdList: 2993
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52925
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

ChromaDex

Tel: --
Fax: --
Email: sales@chromadex.com
Country: United States
ProdList: 2501
Advantage: 76

480-54-6, RETRORSINERelated Search:

ALLYL ISOVALERATE 3-METHOXYPYRROLIDINE (2-Propenyloxy)propanol Butyl hydroxyacetate 3-ALLYLOXY-1,2-PROPANEDIOL 2-Dimethylaminoethyl acetate DIMETHYL 2-METHYLADIPATE 3-Butoxypropanamine 2-HYDROXY-3-METHYLBUTYRIC ACID 3-Pyrrolidinol 2-HYDROXY-N-BUTYRIC ACID ETHYL ESTER RETRORSINE Methyl (R)-(+)-lactate ISO-PROPYL ACRYLATE ISOBUTYRIC ACID N-PROPYL ESTER 3-(DIMETHYLAMINO)PROPYL ACRYLATE 1-AMINO-5-HEXENE 2-METHYL-5-HEXEN-2-OL

BETA-LONGILOBINE

12,18-DIHYDROXYSENECIONAN-11,16-DIONE

RETRORSIN

RETRORSINE

16-dione,12,18-dihydroxy-senecionan-1

5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-3-ethylidene-4

cis-retronecicacidesterofretronecine

methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione

Retrosine

trans-15-ethylidene-12beta-hydroxy-12alpha-hydroxymethyl-13beta-methylsenec-1-

RETRORSINE(AS)

β-Longilobine, 12,18-Dihydroxysenecionan-11,16-dione

β-Longilobine

Retrorcine

[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, (3Z,5R,6S,14aR,14bR)-

480-54-6

C18H23O5N