ChemicalBook > CAS DataBase List > 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
- Product Name
- 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
- CAS No.
- 226907-52-4
- Chemical Name
- 6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
- Synonyms
- 1V136;CL087;SM360320;SM360320, 10 mM in DMSO;SM-360320?(Synonyms: CL-087);Toll-Like Receptor 7 Ligand II;6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol;6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one;8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-;TLR7,Inhibitor,Th1,Toll-like Receptor (TLR),SM360320,antitumor effect,oral,DNA vaccines,inhibit
- CBNumber
- CB12582994
- Molecular Formula
- C15H17N5O3
- Formula Weight
- 315.33
- MOL File
- 226907-52-4.mol
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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Property
- Density
- 1.356
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17228
- Product name
- Toll-Like Receptor 7 Ligand II
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $153
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17228
- Product name
- Toll-Like Receptor 7 Ligand II
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $290
- Updated
- 2024/03/01
American Custom Chemicals Corporation
- Product number
- API0014408
- Product name
- 6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.23
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 093250
- Product name
- 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $1286
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0014408
- Product name
- 6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $2033.85
- Updated
- 2021/12/16
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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Chemical Properties,Usage,Production
Uses
SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].
References
[1] Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. DOI:10.1038/cgt.2008.91
[2] Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. DOI:10.1073/pnas.0510801103
6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol Suppliers
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