ChemicalBook > CAS DataBase List > Nodinitib-1

Nodinitib-1

Product Name: Nodinitib-1
CAS No.: 799264-47-4
Chemical Name: Nodinitib-1
Synonyms: ML 130;Nodinitib-1;Noditinib-1;CID-1088438;Noditiniβ-1;ML-130;ML 130;130 (Nodinitib-1);ML130;CID-1088438;Nodinitib-1 ，S2863;ML130 (Nodinitib-1)
CBNumber: CB12591864
Molecular Formula: C14H13N3O2S
Formula Weight: 287.34
MOL File: 799264-47-4.mol

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Nodinitib-1 Property

Melting point:: 191-192 °C (decomp)
Boiling point:: 532.5±43.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: >10mg/mL
form: powder
pka: 2.55±0.10(Predicted)
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0379
Product name: Nodinitib-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $136
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0379
Product name: Nodinitib-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $538
Updated: 2025/07/31

Cayman Chemical

Product number: 11040
Product name: Nodinitib-1
Purity: ≥95%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 11040
Product name: Nodinitib-1
Purity: ≥95%
Packaging: 10mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 11040
Product name: Nodinitib-1
Purity: ≥95%
Packaging: 25mg
Price: $193
Updated: 2024/03/01

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Nodinitib-1 Chemical Properties,Usage,Production

Uses

Noditinib-1 is a potent and selective inhibitor of NOD1-induced NF-κB activation. Mutations in NOD proteins have been associated with various inflammatory diseases and Noditinib-1 shows promise as a potential therapeutic agent.

Definition

ChEBI: 1-(4-methylphenyl)sulfonyl-2-benzimidazolamine is a sulfonamide.

Biological Activity

Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2.

IC 50

NOD1

Nodinitib-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Nodinitib-1 Suppliers

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View Lastest Price from Nodinitib-1 manufacturers

Career Henan Chemical Co

Product: Nodinitib-1 799264-47-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

799264-47-4, Nodinitib-1Related Search:

M348 ML-228 VU0456810 9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- ML-327 AG 1478 HYDROCHLORIDE Paclitaxel Trametinib Veliparib Olaparib ML402 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide ML-098 [(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone 9-Azabicyclo[3.3.1]nonane-9-acetamide, N-(2-chlorophenyl)-3-[(3,4,5-trimethoxybenzoyl)amino]-, (3-exo)- ML 339 ML 141 ML198

Nodinitib-1

1H-BenziMidazol-2-aMine, 1-[(4-Methylphenyl)sulfonyl]-

ML 130

1-[(4-Methylphenyl)sulfonyl]-1H-benziMidazol-2-aMine

Noditinib-1

ML130 (Nodinitib-1)

CID-1088438

1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-ylamine

ML130;CID-1088438

ML-130;ML 130

130 (Nodinitib-1)

Nodinitib-1 USP/EP/BP

Noditiniβ-1

1-Tosyl-1H-benzo[d]imidazol-2-amine

Nodinitib1,CID1088438,Inhibitor,NOD-like Receptor (NLR),Nodinitib 1,ML-130,ML 130,Nodinitib-1,CID 1088438,inhibit

1-(4-methylphenyl)sulfonylbenzimidazol-2-amine

ML130, NOD1 inhibitor

Nodinitib-1, 10 mM in DMSO

1-[(4-Methylbenzene)sulfonyl]-1H-1,3-benzodiazol-2-amine

Nodinitib-1 (ML130)

Nodinitib-1 ，S2863

799264-47-4

API

NF-kB

Amines

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds