3,5-Difluoroanisole

Product Name: 3,5-Difluoroanisole
CAS No.: 93343-10-3
Chemical Name: 3,5-Difluoroanisole
Synonyms: 3-difluoroanisile;3,5-DIFLUOROANISOLE;3，5-difluoroanisile;3,5-two fluorineether;3,5-Difluoroanisole98%;3,5-Difluoroanisole>3,5-Difluoroanisole 98%;3,5-Difluoroanisole,97%;3,5- difluorobenzyl ether;1,3-difluoro-5-Methoxybenzene
CBNumber: CB1263266
Molecular Formula: C7H6F2O
Formula Weight: 144.12
MOL File: 93343-10-3.mol

More

Less

3,5-Difluoroanisole Property

Boiling point:: 145-148°C
Density: 1.234 g/mL at 25 °C (lit.)
refractive index: n20/D 1.466(lit.)
Flash point:: 111 °F
storage temp.: Sealed in dry,2-8°C
form: Liquid
Specific Gravity: 1.234
color: Clear colorless
BRN: 4966844
CAS DataBase Reference: 93343-10-3(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,F
Risk Statements: 10-36/37/38
Safety Statements: 16-26-36/37/39-7/9
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Flammable
HazardClass: 3
PackingGroup: III
HS Code: 29093090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D2463
Product name: 3,5-Difluoroanisole
Purity: >97.0%(GC)
Packaging: 10g
Price: $134
Updated: 2025/07/31

TRC

Product number: D445395
Product name: 3,5-Difluoroanisole
Packaging: 10g
Price: $105
Updated: 2021/12/16

TRC

Product number: D445395
Product name: 3,5-Difluoroanisole
Packaging: 100g
Price: $625
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0020929
Product name: 3,5-DIFLUOROANISOLE
Purity: 95.00%
Packaging: 2.5G
Price: $746.88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0020929
Product name: 3,5-DIFLUOROANISOLE
Purity: 95.00%
Packaging: 5G
Price: $808.96
Updated: 2021/12/16

More

Less

3,5-Difluoroanisole Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

3,5-Difluoroanisole is used in the preparation of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists. Also used in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors.

General Description

The structure and vibrations of 3,5-difluoroanisole in first electronically excited state were studied by mass-analyzed resonant two-photon ionization technique as well as the quantum chemical calculations.

Synthesis

2713-34-0

74-88-4

93343-10-3

To a stirred suspension of 3,5-difluorophenol (12.5 g, 96 mmol) and potassium carbonate (66.0 g, 480 mmol) in acetone (400 mL) was added methyl iodide (27 mL, 480 mmol) in a single addition. The reaction mixture was then heated to reflux at 60 °C for 18 hours. After cooling to room temperature, the excess solvent was evaporated under reduced pressure, 150 mL of water was added and extracted with ether (2 x 300 mL). The combined organic layers were washed sequentially with 0.1 M sodium hydroxide solution (100 mL) and water (100 mL), dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3,5-difluoroanisole (12.0 g, 80% yield) as a colorless oil.1H-NMR (400 MHz, CDCl3) δppm: 3.81 (s, 3H), 6.43- 6.46 (m, 3H).

References

[1] Tetrahedron Letters, 2004, vol. 45, # 1, p. 95 - 98
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00138
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00140
[4] Patent: US6149990, 2000, A

3,5-Difluoroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3,5-Difluoroanisole Suppliers

Americas 1 Belgium 1 China 208 Europe 4 France 1 Germany 4 India 2 Italy 1 Japan 3 Jordan 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 18 United States 32 Global 280

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

More

Less

View Lastest Price from 3,5-Difluoroanisole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,5-Difluoroanisole 93343-10-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-09

Shaanxi Dideu Medichem Co. Ltd

Product: 3,5-Difluoroanisole 93343-10-3
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3,5-Difluoroanisole 93343-10-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

93343-10-3, 3,5-DifluoroanisoleRelated Search:

4-Fluoroanisole 3-Fluoroanisole 1,3-Difluorobenzene 3,5-Dimethylanisole Anisole Dimethyl ether 2,4-Difluorobenzoic acid 1,2-Difluorobenzene PENTAFLUOROPHENOXYACETIC ACID PENTAFLUOROPHENYL METHACRYLATE 2,3,5,6-TETRAFLUOROANISOLE PENTAFLUOROPHENYL ACRYLATE 3,4,5-Trifluoroanisole 2,3,4,5,6-PENTAFLUOROANISOLE 9-FLUORENYLMETHYL PENTAFLUOROPHENYL CARBONATE FMOC-ASP(OTBU)-OPFP FMOC-GLY-OPFP 2,4-Dinitrofluorobenzene

3,5-two fluorineether

1,3-Difluoro-5-methoxybenzene, 3,5-Difluorophenyl methyl ether

1,3-difluoro-5-Methoxybenzene

3-difluoroanisile

3,5-Difluoroanisole,97%

3,5-DIFLUOROANISOLE

3,5-DIFLUORO-1-METHOXYBENZENE

Benzene, 1,3-difluoro-5-methoxy-

3，5-difluoroanisile

3,5-Difluoroanisole 98%

3,5-Difluoroanisole98%

3,5-Difluoroanisole&gt

3,5- difluorobenzyl ether

3,5-Difluoroanisole ISO 9001：2015 REACH

93343-10-3

3343-10-3

F2C7H6O

Ethers

Organic Building Blocks

Oxygen Compounds

Building Blocks

Aromatic Ethers

Anisole

Miscellaneous

Ethers

Organic Building Blocks

Oxygen Compounds

Other fluorin-contained compounds